THUM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THUM2_HUMAN
• UniProt AC: Q9BTF0
• Protein Name: THUMP domain-containing protein 2
• Gene Name: THUMPD2
• Organism: Homo sapiens (Human).
• Sequence Length: 503
• Protein Sequence: MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQVEYISGKVFFTTCSDLNMLKKLKSAERLFLLIKKQFPLIISSVSKGKIFNEMQRLINEDPGSWLNAISIWKNLLELDAKKEKLSQRDDNQLKRKVGENEIIAKKLKIEQMQKIEENRDCQLEKQIKEETLEQRDFTTKSEKFQEEEFQNDIEKAIDTHNQNDLTFRVSCRCSGTIGKAFTAQEVGKVIGIAIMKHFGWKADLRNPQLEIFIHLNDIYSVVGIPVFRVSLASRAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDIKSILQEMERVLHVGGTIVLLLSEDHHRRLTDCKESNIPFNSKDSHTDEPGIKKCLNPEEKTGAFKTASTSFEASNHKFLDRMSPFGSLVPVECYKVSLGKTDAFICKYKKSHSSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Methylation	RFFCTAGRGLEPFVM CEEEECCCCCHHHHH	44.02	54560199
134	Methylation	QRDDNQLKRKVGENE HCCHHHHHHHHCCHH	40.17	-
134	Sumoylation	QRDDNQLKRKVGENE HCCHHHHHHHHCCHH	40.17	-
136	Methylation	DDNQLKRKVGENEII CHHHHHHHHCCHHHH	53.67	-
136	Sumoylation	DDNQLKRKVGENEII CHHHHHHHHCCHHHH	53.67	-
148	Methylation	EIIAKKLKIEQMQKI HHHHHHHHHHHHHHH	53.74	-
153	Ubiquitination	KLKIEQMQKIEENRD HHHHHHHHHHHHCCC	43.18	21906983
165	Ubiquitination	NRDCQLEKQIKEETL CCCHHHHHHHHHHHH	66.95	21906983
171	Phosphorylation	EKQIKEETLEQRDFT HHHHHHHHHHHCCCC	36.36	26074081
178	Phosphorylation	TLEQRDFTTKSEKFQ HHHHCCCCCCHHHHH	37.29	26074081
179	Phosphorylation	LEQRDFTTKSEKFQE HHHCCCCCCHHHHHH	32.35	26074081
183	Ubiquitination	DFTTKSEKFQEEEFQ CCCCCHHHHHHHHHH	60.48	21906983
195	Ubiquitination	EFQNDIEKAIDTHNQ HHHHHHHHHHHHCCC	51.48	21906983
292	Phosphorylation	TIAWAMASLADIKAG HHHHHHHHHHHHHCC	15.82	23090842
350	Ubiquitination	KAAGLEDKIELLKIS HHCCCHHHHHEEEEE	28.80	-
409	Ubiquitination	GTIVLLLSEDHHRRL CEEEEEECCCHHHCC	40.73	21906983
439	Ubiquitination	HTDEPGIKKCLNPEE CCCCCCHHHCCCHHH	43.26	2190698
457	Phosphorylation	AFKTASTSFEASNHK CCCCCCCCCHHCCCC	20.70	25159151
464	Ubiquitination	SFEASNHKFLDRMSP CCHHCCCCCHHHCCC	52.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THUM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THUM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THUM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPX2_HUMAN	TPX2	physical	22939629
TRM1_HUMAN	TRMT1	physical	22939629
SPDLY_HUMAN	SPDL1	physical	28514442
LACRT_HUMAN	LACRT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.