dbPTM

HSPB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSPB3_HUMAN
UniProt AC	Q12988
Protein Name	Heat shock protein beta-3
Gene Name	HSPB3
Organism	Homo sapiens (Human).
Sequence Length	150
Subcellular Localization	Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
Protein Description	Inhibitor of actin polymerization..
Protein Sequence	MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
53	Phosphorylation	RKTRAAQSPPVDSAA HHHCCCCCCCCCCCC	26.84	26437602
62	Phosphorylation	PVDSAAETPPREGKS CCCCCCCCCCCCCCC	33.59	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSPB3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSPB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSPB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AN32A_HUMAN	ANP32A	physical	16169070
MED31_HUMAN	MED31	physical	16169070
RTL8A_HUMAN	FAM127B	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
OLFL3_HUMAN	OLFML3	physical	16169070
MED8_HUMAN	MED8	physical	16169070
RM38_HUMAN	MRPL38	physical	16169070
NSMF_HUMAN	NSMF	physical	16169070
RAMP3_HUMAN	RAMP3	physical	16169070
BODG_HUMAN	BBOX1	physical	16169070
PRP4B_HUMAN	PRPF4B	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
ZZEF1_HUMAN	ZZEF1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSPB3_HUMAN

Related Literatures of Post-Translational Modification