NSMF_HUMAN - dbPTM
NSMF_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NSMF_HUMAN
UniProt AC Q6X4W1
Protein Name NMDA receptor synaptonuclear signaling and neuronal migration factor
Gene Name NSMF
Organism Homo sapiens (Human).
Sequence Length 530
Subcellular Localization Nucleus . Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm . Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane
Peripheral membrane protein . Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome
Protein Description Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells..
Protein Sequence MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVYTISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGSRQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIERKLNVYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYRVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGAAASRRR
------CCHHHHHHH		-
6Phosphorylation--MGAAASRRRALRS
--CCHHHHHHHHHHH		30206219
72PhosphorylationPQNKRRLSLVSNGCY
CCCCHHEEEEECCCC		29449344
75PhosphorylationKRRLSLVSNGCYEGS
CHHEEEEECCCCCCC		29449344
79PhosphorylationSLVSNGCYEGSLSEE
EEEECCCCCCCCCCC		29449344
82PhosphorylationSNGCYEGSLSEEPSI
ECCCCCCCCCCCCCC		29449344
84PhosphorylationGCYEGSLSEEPSIRK
CCCCCCCCCCCCCCC		29449344
91AcetylationSEEPSIRKPAGEGPQ
CCCCCCCCCCCCCCC		7306267
151PhosphorylationGGSREDVSRPCQSWA
CCCHHHCCCCCHHHC		22210691
160PhosphorylationPCQSWAGSRQGSKEC
CCHHHCCCCCCCCCC		22210691
164PhosphorylationWAGSRQGSKECPGCA
HCCCCCCCCCCCCCC		24719451
203PhosphorylationRKKLERMYSVDRVSD
HHHHHHHHCCCCCCC		28450419
204PhosphorylationKKLERMYSVDRVSDD
HHHHHHHCCCCCCCC		27987026
209PhosphorylationMYSVDRVSDDIPIRT
HHCCCCCCCCCCCCC		23186163
225 (in isoform 3)Phosphorylation--
225PhosphorylationFPKENLFSFQTATTT
CCCCCCCCEECCHHH		25072903
228PhosphorylationENLFSFQTATTTMQA
CCCCCEECCHHHHHH		25072903
230PhosphorylationLFSFQTATTTMQAIS
CCCEECCHHHHHHHH		25072903
231PhosphorylationFSFQTATTTMQAISV
CCEECCHHHHHHHHH		25072903
232PhosphorylationSFQTATTTMQAISVF
CEECCHHHHHHHHHH		25072903
237PhosphorylationTTTMQAISVFRGYAE
HHHHHHHHHHHHHHH		25072903
242PhosphorylationAISVFRGYAERKRRK
HHHHHHHHHHHHHHH		-
286PhosphorylationFAERRERSFSRSWSD
HHHHHHHHHCCCCCC		16565220
288PhosphorylationERRERSFSRSWSDPT
HHHHHHHCCCCCCCC		22817900
290PhosphorylationRERSFSRSWSDPTPM
HHHHHCCCCCCCCCC		29978859
292PhosphorylationRSFSRSWSDPTPMKA
HHHCCCCCCCCCCCC		29978859
295PhosphorylationSRSWSDPTPMKADTS
CCCCCCCCCCCCCCC		29978859
301PhosphorylationPTPMKADTSHDSRDS
CCCCCCCCCCCCCCC		23312004
302PhosphorylationTPMKADTSHDSRDSS
CCCCCCCCCCCCCCH		23312004
305PhosphorylationKADTSHDSRDSSDLQ
CCCCCCCCCCCHHHH		23312004
352PhosphorylationPPKVMLISSKVPKAE
CCEEEEEECCCCHHH		30631047
353PhosphorylationPKVMLISSKVPKAEY
CEEEEEECCCCHHHH		30631047
400AcetylationRKLNVYHKGAKIWKM
HHHCCHHHHHHHEEE		7683129
424AcetylationHLYLLKNKVATFAKV
CEEEECCCEEEEEEC		12435423
433AcetylationATFAKVEKEEDMIHF
EEEEECCCHHHHHHH		12435435
442AcetylationEDMIHFWKRLSRLMS
HHHHHHHHHHHHHHH		12435447
480O-linked_GlycosylationKLFQNLRTLMTPYRV
HHHHHHHHHCCCEEE		30379171
483PhosphorylationQNLRTLMTPYRVTFE
HHHHHHCCCEEEEEC		30576142
496PhosphorylationFESPLELSAQGKQMI
ECCCCEECHHHHHHH		30576142
505PhosphorylationQGKQMIETYFDFRLY
HHHHHHHHHHHHHHH		27174698
506PhosphorylationGKQMIETYFDFRLYR
HHHHHHHHHHHHHHH		27174698
512PhosphorylationTYFDFRLYRLWKSRQ
HHHHHHHHHHHHHCC		22210691
517PhosphorylationRLYRLWKSRQHSKLL
HHHHHHHHCCCCCCC		27174698
521PhosphorylationLWKSRQHSKLLDFDD
HHHHCCCCCCCCCCC		22617229
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NSMF_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NSMF_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NSMF_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPT5H_HUMANSUPT5Hphysical
10199401
RPB1_HUMANPOLR2Aphysical
10199401
KCD15_HUMANKCTD15physical
28514442
SUH_HUMANRBPJphysical
28514442
RN123_HUMANRNF123physical
28514442
NDUF5_HUMANNDUFAF5physical
28514442
Drug and Disease Associations
Kegg Disease
H00255 Hypogonadotropic hypogonadism, including: Kallmann syndrome (KAL); Fertile eunuch syndrome (FEUNS)
OMIM Disease
614838Hypogonadotropic hypogonadism 9 with or without anosmia (HH9)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NSMF_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory