OLFL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OLFL3_HUMAN
• UniProt AC: Q9NRN5
• Protein Name: Olfactomedin-like protein 3
• Gene Name: OLFML3
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Secreted .
• Protein Description: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes..
• Protein Sequence: MGPSTPLLILFLLSWSGPLQGQQHHLVEYMERRLAALEERLAQCQDQSSRHAAELRDFKNKMLPLLEVAEKEREALRTEADTISGRVDRLEREVDYLETQNPALPCVEFDEKVTGGPGTKGKGRRNEKYDMVTDCGYTISQVRSMKILKRFGGPAGLWTKDPLGQTEKIYVLDGTQNDTAFVFPRLRDFTLAMAARKASRVRVPFPWVGTGQLVYGGFLYFARRPPGRPGGGGEMENTLQLIKFHLANRTVVDSSVFPAEGLIPPYGLTADTYIDLAADEEGLWAVYATREDDRHLCLAKLDPQTLDTEQQWDTPCPRENAEAAFVICGTLYVVYNTRPASRARIQCSFDASGTLTPERAALPYFPRRYGAHASLRYNPRERQLYAWDDGYQIVYKLEMRKKEEEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGPSTPLLILF ----CCCCHHHHHHH	36.61	24043423
5	Phosphorylation	---MGPSTPLLILFL ---CCCCHHHHHHHH	22.53	24043423
14	Phosphorylation	LLILFLLSWSGPLQG HHHHHHHHCCCCCCC	22.73	24043423
16	Phosphorylation	ILFLLSWSGPLQGQQ HHHHHHCCCCCCCCC	27.45	24043423
29	Phosphorylation	QQHHLVEYMERRLAA CCHHHHHHHHHHHHH	9.22	24043423
129 (in isoform 3)	Phosphorylation	-	11.77	21406692
129	Phosphorylation	KGRRNEKYDMVTDCG CCCCCCCCCEEECCC	11.77	-
133 (in isoform 3)	Phosphorylation	-	20.95	21406692
137	Phosphorylation	DMVTDCGYTISQVRS CEEECCCCCHHHHHH	13.77	25072903
137 (in isoform 3)	Phosphorylation	-	13.77	21406692
138	Phosphorylation	MVTDCGYTISQVRSM EEECCCCCHHHHHHH	10.23	25072903
139 (in isoform 3)	Phosphorylation	-	1.72	21406692
140	Phosphorylation	TDCGYTISQVRSMKI ECCCCCHHHHHHHHH	18.15	25072903
144	Phosphorylation	YTISQVRSMKILKRF CCHHHHHHHHHHHHH	26.10	25072903
160 (in isoform 3)	Phosphorylation	-	45.85	22210691
177	N-linked_Glycosylation	YVLDGTQNDTAFVFP EEEECCCCCEEEECH	48.73	15280020
177	N-linked_Glycosylation	YVLDGTQNDTAFVFP EEEECCCCCEEEECH	48.73	UniProtKB CARBOHYD
248	N-linked_Glycosylation	LIKFHLANRTVVDSS HHHHHHCCCEEECCC	46.66	15280020
248	N-linked_Glycosylation	LIKFHLANRTVVDSS HHHHHHCCCEEECCC	46.66	UniProtKB CARBOHYD
369	Phosphorylation	LPYFPRRYGAHASLR CCCCCCCCCCCEECC	21.68	-
374	Phosphorylation	RRYGAHASLRYNPRE CCCCCCEECCCCHHC	11.96	-
377	Phosphorylation	GAHASLRYNPRERQL CCCEECCCCHHCCCE	34.51	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OLFL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OLFL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OLFL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEZ1_HUMAN	FEZ1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
MA7D2_HUMAN	MAP7D2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.