MYOM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOM2_HUMAN
• UniProt AC: P54296
• Protein Name: Myomesin-2
• Gene Name: MYOM2
• Organism: Homo sapiens (Human).
• Sequence Length: 1465
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, M line.
• Protein Description: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent..
• Protein Sequence: MSLVTVPFYQKRHRHFDQSYRNIQTRYLLDEYASKKRASTQASSQKSLSQRSSSQRASSQTSLGGTICRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQRFLSELAHLEEDVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFLFVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIAIYQDDLEGDAQVPGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYFIEKSVVGSGSWQRVNAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQTTTANRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKEISAGVDEQGNIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKEDLGTYSVSVSDTDGVSSSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKGRVRFWLQAEHLSPDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFSIENEGTYTVQIHDGKAKSQSSLVLIGDAFKTVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETETLPNLERGICELLIPKLSKKDHGEYKATLKDDRGQDVSILEIAGKVYDDMILAMSRVCGKSASPLKVLCTPEGIRLQCFMKYFTDEMKVNWCHKDAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAFAEFQQFKAAAFAEKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKNKYGGEKIDVTVSVYKHGEKIPDMAPPQQAKPKLIPASASAAGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLVTVPFY ------CCCEECCCC	42.74	24043423
5	Phosphorylation	---MSLVTVPFYQKR ---CCCEECCCCHHH	27.96	24114839
9	Phosphorylation	SLVTVPFYQKRHRHF CCEECCCCHHHHCCC	13.68	22673903
19	Phosphorylation	RHRHFDQSYRNIQTR HHCCCCHHHHHHHHH	28.09	26437602
20	Phosphorylation	HRHFDQSYRNIQTRY HCCCCHHHHHHHHHH	11.31	-
32	Phosphorylation	TRYLLDEYASKKRAS HHHHHHHHHHHHHHC	18.81	-
34	Phosphorylation	YLLDEYASKKRASTQ HHHHHHHHHHHHCHH	37.50	-
39	O-linked_Glycosylation	YASKKRASTQASSQK HHHHHHHCHHHHHHH	25.70	31492838
40	O-linked_Glycosylation	ASKKRASTQASSQKS HHHHHHCHHHHHHHH	27.46	31492838
47	Phosphorylation	TQASSQKSLSQRSSS HHHHHHHHHHHHCHH	26.14	26437602
49	Phosphorylation	ASSQKSLSQRSSSQR HHHHHHHHHHCHHHH	30.55	-
52	Phosphorylation	QKSLSQRSSSQRASS HHHHHHHCHHHHHHH	27.06	26437602
58	Phosphorylation	RSSSQRASSQTSLGG HCHHHHHHHCCCHHH	25.76	19764811
59	Phosphorylation	SSSQRASSQTSLGGT CHHHHHHHCCCHHHH	36.17	19764811
61	Phosphorylation	SQRASSQTSLGGTIC HHHHHHCCCHHHHHH	28.06	-
62	Phosphorylation	QRASSQTSLGGTICR HHHHHCCCHHHHHHH	19.85	26437602
66	Phosphorylation	SQTSLGGTICRVCAK HCCCHHHHHHHHHHE	18.33	-
76	Phosphorylation	RVCAKRVSTQEDEEQ HHHHEECCCCCCHHH	28.53	9529381
77	Phosphorylation	VCAKRVSTQEDEEQE HHHEECCCCCCHHHH	32.87	26437602
89	Phosphorylation	EQENRSRYQSLVAAY HHHHHHHHHHHHHHH	12.05	26437602
91	Phosphorylation	ENRSRYQSLVAAYGE HHHHHHHHHHHHHHH	18.84	26437602
96	Phosphorylation	YQSLVAAYGEAKRQR HHHHHHHHHHHHHHH	13.03	-
100	Acetylation	VAAYGEAKRQRFLSE HHHHHHHHHHHHHHH	44.77	155341
106	Phosphorylation	AKRQRFLSELAHLEE HHHHHHHHHHHHHHH	28.05	22673903
145	Phosphorylation	KLAWERHTFEERISR HHHHHHHCHHHHHHC	38.67	26437602
151	Phosphorylation	HTFEERISRAPEILV HCHHHHHHCCCHHHH	28.72	26437602
162	Phosphorylation	EILVRLRSHTVWERM HHHHHHCCCCHHHCE	28.27	26437602
164	Phosphorylation	LVRLRSHTVWERMSV HHHHCCCCHHHCEEE	28.67	26437602
170	Phosphorylation	HTVWERMSVKLCFTV CCHHHCEEEEEEEEE	23.48	24719451
192	Phosphorylation	VQWYKDGSLICQAAE EEEEECCCEEEEECC	25.37	20833797
203	Phosphorylation	QAAEPGKYRIESNYG EECCCCCEEEEECCE	23.80	26437602
207	Phosphorylation	PGKYRIESNYGVHTL CCCEEEEECCEEEEE	32.74	26437602
209	Phosphorylation	KYRIESNYGVHTLEI CEEEEECCEEEEEEE	29.79	26437602
287	Phosphorylation	FLEKFGVTFRREGET HHHHHCCEEEECCCE	16.29	26437602
294	Phosphorylation	TFRREGETVTLKCTM EEEECCCEEEEEEEE	29.64	26437602
296	Phosphorylation	RREGETVTLKCTMLV EECCCEEEEEEEEEE	28.11	26437602
317	Phosphorylation	VQPRAEWYRDDVLLK CCCCCHHHCCCCEEC	8.82	-
341	Phosphorylation	GEGQASLSFSHLHKD CCCEEEEEEEECCCC	23.39	26437602
354	Phosphorylation	KDDEGLYTLRIVSRG CCCCCEEEEEEEEEC	18.01	24719451
442	Phosphorylation	APVKICKYPVTGLFE CCEEEECCCCCCEEC	9.87	26437602
445	Phosphorylation	KICKYPVTGLFEGRS EEECCCCCCEECCCE	24.54	26437602
462	Phosphorylation	FRVRAVNSAGISRPS EEEEEECCCCCCCCH	22.67	23090842
466	Phosphorylation	AVNSAGISRPSRVSD EECCCCCCCCHHHHH	36.90	23090842
500	Phosphorylation	GEKEIAIYQDDLEGD CCCEEEEEECCCCCC	9.25	-
520	Phosphorylation	PPTGVHASEISRNYV CCCCCCHHHCCCCEE	22.15	26437602
526	Phosphorylation	ASEISRNYVVLSWEP HHHCCCCEEEEEECC	7.27	22673903
530	Phosphorylation	SRNYVVLSWEPPTPR CCCEEEEEECCCCCC	20.13	19764811
535	Phosphorylation	VLSWEPPTPRGKDPL EEEECCCCCCCCCCE	36.01	26437602
549	Phosphorylation	LMYFIEKSVVGSGSW EEEEEEEECCCCCCC	14.83	26437602
553	Phosphorylation	IEKSVVGSGSWQRVN EEEECCCCCCCEEEE	20.31	26437602
555	Phosphorylation	KSVVGSGSWQRVNAQ EECCCCCCCEEEEHH	23.02	26437602
563	Phosphorylation	WQRVNAQTAVRSPRY CEEEEHHHHCCCCCE	25.39	26437602
567	Phosphorylation	NAQTAVRSPRYAVFD EHHHHCCCCCEEEEE	13.71	24719451
581	Phosphorylation	DLMEGKSYVFRVLSA EECCCCEEEEEHHHC	13.70	24719451
594	Phosphorylation	SANRHGLSEPSEITS HCCCCCCCCCCCCCC	52.64	19764811
597	Phosphorylation	RHGLSEPSEITSPIQ CCCCCCCCCCCCCCC	37.26	19764811
600	Phosphorylation	LSEPSEITSPIQAQD CCCCCCCCCCCCCCC	25.13	19764811
601	Phosphorylation	SEPSEITSPIQAQDV CCCCCCCCCCCCCCE	26.18	19764811
613	Phosphorylation	QDVTVVPSAPGRVLA CCEEEECCCCCCEEE	35.17	26437602
626	Phosphorylation	LASRNTKTSVVVQWD EEECCCCEEEEEEEC	25.39	26437602
627	Phosphorylation	ASRNTKTSVVVQWDR EECCCCEEEEEEECC	17.92	26437602
675	Phosphorylation	RFVVHGLTTGEQYIF CEEEECCCCCCEEEE	37.03	22673903
676	Phosphorylation	FVVHGLTTGEQYIFR EEEECCCCCCEEEEE	43.71	26437602
693	Phosphorylation	AVNAVGMSENSQESD EEEEECCCCCCCCCC	27.91	22210691
696	Phosphorylation	AVGMSENSQESDVIK EECCCCCCCCCCEEE	31.13	22210691
699	Phosphorylation	MSENSQESDVIKVQA CCCCCCCCCEEEEEE	29.55	22210691
737	Phosphorylation	GWKVPKFSGGSPILG CEECCCCCCCCCCEE	48.66	19764811
740	Phosphorylation	VPKFSGGSPILGYYL CCCCCCCCCCEEEEE	16.58	22673903
749	Acetylation	ILGYYLDKREVHHKN CEEEEECCCCCCCCC	48.11	19863229
762	Phosphorylation	KNWHEVNSSPSKPTI CCHHCCCCCCCCCEE	49.12	26437602
763	Phosphorylation	NWHEVNSSPSKPTIL CHHCCCCCCCCCEEE	28.17	22673903
765	Phosphorylation	HEVNSSPSKPTILTV HCCCCCCCCCEEEEE	53.89	22673903
828	Phosphorylation	FCEVRDTSLVMLWKA EEEEECCEEEEEEEC	24.21	26437602
838	Phosphorylation	MLWKAPVYSGSSPVS EEEECCCCCCCCCCC	13.27	-
847	Phosphorylation	GSSPVSGYFVDFREE CCCCCCEEEEEEEHH	7.91	-
861	Phosphorylation	EDAGEWITVNQTTTA HCCCCCEEEECCCCC	17.93	24905233
865	Phosphorylation	EWITVNQTTTANRYL CCEEEECCCCCCCEE	22.40	24905233
866	Phosphorylation	WITVNQTTTANRYLK CEEEECCCCCCCEEE	17.72	24905233
867	Phosphorylation	ITVNQTTTANRYLKV EEEECCCCCCCEEEE	25.89	24905233
871	Phosphorylation	QTTTANRYLKVSDLQ CCCCCCCEEEECCCC	15.64	19764811
875	Phosphorylation	ANRYLKVSDLQQGKT CCCEEEECCCCCCCE	30.89	19764811
882	Phosphorylation	SDLQQGKTYVFRVRA CCCCCCCEEEEEEEE	31.57	29083192
883	Phosphorylation	DLQQGKTYVFRVRAV CCCCCCEEEEEEEEE	10.90	29083192
899	Phosphorylation	ANGVGKPSDTSEPVL CCCCCCCCCCCCCEE	57.94	22673903
901	Phosphorylation	GVGKPSDTSEPVLVE CCCCCCCCCCCEEEE	39.05	26437602
902	Phosphorylation	VGKPSDTSEPVLVEA CCCCCCCCCCEEEEE	44.91	22673903
946	Phosphorylation	SQFTWCKSYEEISDD HHCEEECCHHHCCCC	34.34	20833797
947	Phosphorylation	QFTWCKSYEEISDDE HCEEECCHHHCCCCC	11.77	26437602
951	Phosphorylation	CKSYEEISDDERFKI ECCHHHCCCCCCEEE	42.14	26657352
968	Phosphorylation	VGDHSKLYLKNPDKE CCCCCEEEECCCCHH	21.26	-
1015	Phosphorylation	SNEIKNPTIPLKSEL CCCCCCCCCCCCCHH	44.62	24719451
1024	Phosphorylation	PLKSELAYEIFDKGR CCCCHHHHHHHHHCC	23.37	22673903
1042	Phosphorylation	WLQAEHLSPDASYRF EEEEECCCCCCCEEE	23.73	26437602
1046	Phosphorylation	EHLSPDASYRFIIND ECCCCCCCEEEEECC	24.99	22673903
1047	Phosphorylation	HLSPDASYRFIINDR CCCCCCCEEEEECCC	15.97	22673903
1057	Phosphorylation	IINDREVSDSEIHRI EECCCCCCHHHEEEE	30.57	19764811
1059	Phosphorylation	NDREVSDSEIHRIKC CCCCCCHHHEEEEEC	30.83	26437602
1070	Phosphorylation	RIKCDKATGIIEMVM EEECCCCCCCEEEEE	34.35	21712546
1081	Phosphorylation	EMVMDRFSIENEGTY EEEEECEEECCCEEE	29.86	-
1089	Phosphorylation	IENEGTYTVQIHDGK ECCCEEEEEEEECCC	13.03	-
1099	Phosphorylation	IHDGKAKSQSSLVLI EECCCCCCCEEEEEE	39.91	22673903
1101	Phosphorylation	DGKAKSQSSLVLIGD CCCCCCCEEEEEECH	32.50	22673903
1102	Phosphorylation	GKAKSQSSLVLIGDA CCCCCCEEEEEECHH	18.17	22673903
1112	Phosphorylation	LIGDAFKTVLEEAEF EECHHHHHHHHHHHH	24.70	-
1135	Phosphorylation	QGPHFAEYLHWDVTE HCCCHHHHHCCCCCC	10.63	-
1191	Phosphorylation	ELLIPKLSKKDHGEY HHHCHHCCCCCCCCE	43.73	26437602
1272	Phosphorylation	CHKDAKISSSEHMRI ECCCCCCCCCCCCCC	27.40	26437602
1273	Phosphorylation	HKDAKISSSEHMRIG CCCCCCCCCCCCCCC	43.13	26437602
1274	Phosphorylation	KDAKISSSEHMRIGG CCCCCCCCCCCCCCC	25.40	26437602
1315	Phosphorylation	GKDNHQRSLDLSGQA CCCCCEEEEECCCHH	21.47	22673903
1319	Phosphorylation	HQRSLDLSGQAFDEA CEEEEECCCHHHHHH	28.64	22673903
1355	Phosphorylation	GGLPDVVTIMEGKTL CCCCCEEEEECCCEE	17.91	29396449
1392	Phosphorylation	IQLSEHFSVKVEQAK CCCCCCEEEEEEEEE	23.96	26437602
1400	Phosphorylation	VKVEQAKYVSMTIKG EEEEEEEEEEEEEEC	10.77	26437602
1424	Phosphorylation	SINIKNKYGGEKIDV EEEEECCCCCEEEEE	39.49	-
1436	Phosphorylation	IDVTVSVYKHGEKIP EEEEEEEEECCCCCC	6.97	19702290
1459	Phosphorylation	KPKLIPASASAAGQ- CCCCCCCCHHHCCC-	19.87	26437602
1461	Phosphorylation	KLIPASASAAGQ--- CCCCCCHHHCCC---	19.02	19764811

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
76	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYOM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.