AGA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGA11_HUMAN
• UniProt AC: Q8TF27
• Protein Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11
• Gene Name: AGAP11
• Organism: Homo sapiens (Human).
• Sequence Length: 550
• Protein Description: Putative GTPase-activating protein..
• Protein Sequence: MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTIISVTLE ------CCEEEEEEE	27.33	23663014
5	Phosphorylation	---MTIISVTLEIHH ---CCEEEEEEEEEE	12.75	23663014
7	Phosphorylation	-MTIISVTLEIHHHI -CCEEEEEEEEEECC	16.34	23663014
15	Phosphorylation	LEIHHHITERDADRS EEEEECCCCCCCCCC	22.17	23663014
22	Phosphorylation	TERDADRSLTILDEQ CCCCCCCCEEECHHH	30.34	27174698
24	Phosphorylation	RDADRSLTILDEQLY CCCCCCEEECHHHHH	22.27	27174698
31	Phosphorylation	TILDEQLYSFAFSTV EECHHHHHHHCCEEE	11.05	46160281
32	Phosphorylation	ILDEQLYSFAFSTVH ECHHHHHHHCCEEEE	20.77	27174698
36	Phosphorylation	QLYSFAFSTVHITKK HHHHHCCEEEEEEEC	26.54	27174698
37	Phosphorylation	LYSFAFSTVHITKKR HHHHCCEEEEEEECC	15.06	27174698
41	Phosphorylation	AFSTVHITKKRNGGG CCEEEEEEECCCCCC	18.68	27174698
86	Phosphorylation	PTPICKQSMGWSNLF CCCCCCCCCCCHHHC	12.54	24043423
90	Phosphorylation	CKQSMGWSNLFTSEK CCCCCCCHHHCCCCC	20.23	24043423
94	Phosphorylation	MGWSNLFTSEKGSDP CCCHHHCCCCCCCCC	38.86	24114839
95	Phosphorylation	GWSNLFTSEKGSDPD CCHHHCCCCCCCCCH	29.94	24114839
99	Phosphorylation	LFTSEKGSDPDKGRK HCCCCCCCCCHHHHH	57.97	68720569
143	Phosphorylation	LKTWKKKYVTLCSNG HHHCHHHEEEECCCC	13.93	7459045
154	Phosphorylation	CSNGVLTYYSSLGDY CCCCEEHHHHHHHHH	9.37	-
155	Phosphorylation	SNGVLTYYSSLGDYM CCCEEHHHHHHHHHH	6.12	-
161	Phosphorylation	YYSSLGDYMKNIHKK HHHHHHHHHHHHHHH	14.27	7459053
175	Phosphorylation	KEIDLRTSTIKVPGK HCCEECCCEEECCCC	23.00	24719451
195	Phosphorylation	TSACAPISSSKSNGL CHHCCCCCCCCCCCC	27.74	22210691
212	Phosphorylation	DMEALHMSANSDIGL CHHHHHHHCCCCCCC	17.35	22210691
215	Phosphorylation	ALHMSANSDIGLGDS HHHHHCCCCCCCCCC	30.26	22210691
226	Phosphorylation	LGDSICFSPSISSTT CCCCEEECCCCCCCC	17.21	23532336
234	Phosphorylation	PSISSTTSPKLNLPP CCCCCCCCCCCCCCC	21.81	22210691
284	Phosphorylation	IVSVTGQTCHFKATT EEEEECCCCEEECCC	14.86	22210691
304	Phosphorylation	AWVQAIQSQILASLQ HHHHHHHHHHHHHHH	17.05	22210691
309	Phosphorylation	IQSQILASLQSCESS HHHHHHHHHHHHCCC	24.40	22210691
318	Phosphorylation	QSCESSKSKSQLTSQ HHHCCCCCHHHCCCH	39.21	29888752
320	Phosphorylation	CESSKSKSQLTSQSE HCCCCCHHHCCCHHH	37.20	29888752
323	Phosphorylation	SKSKSQLTSQSEAMA CCCHHHCCCHHHHHH	19.65	29888752
324	Phosphorylation	KSKSQLTSQSEAMAL CCHHHCCCHHHHHHH	40.06	29888752
326	Phosphorylation	KSQLTSQSEAMALQS HHHCCCHHHHHHHHH	27.39	29888752
333	Phosphorylation	SEAMALQSIQNMRGN HHHHHHHHHHHHCCC	27.30	29888752
416	Phosphorylation	EGSSQGQTKPSIEST CCCCCCCCCCCCHHH	52.31	11733753
419	Phosphorylation	SQGQTKPSIESTREE CCCCCCCCCHHHHHH	40.31	11733761
422	Phosphorylation	QTKPSIESTREEKER CCCCCCHHHHHHHHH	30.97	11733769
490	Phosphorylation	CGEGDGCTALHLACR CCCCCCCHHHHHHHH	37.47	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGA11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGA11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGA11_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.