MYCD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYCD_HUMAN
• UniProt AC: Q8IZQ8
• Protein Name: Myocardin
• Gene Name: MYOCD
• Organism: Homo sapiens (Human).
• Sequence Length: 938
• Subcellular Localization: Nucleus.
• Protein Description: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity)..
• Protein Sequence: MTLLGSEHSLLIRSKFRSVLQLRLQQRRTQEQLANQGIIPPLKRPAEFHEQRKHLDSDKAKNSLKRKARNRCNSADLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPVDSAVKEAIKGNQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPDAKASDTPSTGSLGTNQDLASGSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNSSSTPLSNTPLSPVKNSFSGQTGVSSFKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSGNPVPNFGDITTVTFPVTPNTLPNYQSSSSTSALSNGFYHFGSTSSSPPISPASSDLSVAGSLPDTFNDASPSFGLHPSPVHVCTEESLMSSLNGGSVPSELDGLDSEKDKMLVEKQKVINELTWKLQQEQRQVEELRMQLQKQKRNNCSEKKPLPFLAASIKQEEAVSSCPFASQVPVKRQSSSSECHPPACEAAQLQPLGNAHCVESSDQTNVLSSTFLSPQCSPQHSPLGAVKSPQHISLPPSPNNPHFLPSSSGAQGEGHRVSSPISSQVCTAQMAGLHSSDKVGPKFSIPSPTFSKSSSAISEVTQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIPRSSRSPTAVLTKPSASFEQASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLKIGSEEPHFDGIMDGFSGKAAEDLFNAHEILPGPLSPMQTQFSPSSVDSNGLQLSFTESPWETMEWLDLTPPNSTPGFSALTTSSPSIFNIDFLDVTDLNLNSSMDLHLQQW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	KARNRCNSADLVNMH HHHHHCCHHHHHHHH	27.13	21712546
131	Phosphorylation	KNILPVDSAVKEAIK CCCCCCCHHHHHHHC	34.88	29083192
138	Sumoylation	SAVKEAIKGNQVSFS HHHHHHHCCCCCEEC	59.88	-
138	Sumoylation	SAVKEAIKGNQVSFS HHHHHHHCCCCCEEC	59.88	-
143	Phosphorylation	AIKGNQVSFSKSTDA HHCCCCCEECCCCCE	17.65	24719451
175	Phosphorylation	RSEDPQNSAGSPPDA CCCCCCCCCCCCCCC	28.85	29255136
178	Phosphorylation	DPQNSAGSPPDAKAS CCCCCCCCCCCCCCC	32.73	29255136
229	Phosphorylation	KQGLGPPSTPIAVHA CCCCCCCCCCCHHEE	50.37	28555341
230	Phosphorylation	QGLGPPSTPIAVHAA CCCCCCCCCCHHEEH	25.20	-
242	Phosphorylation	HAAVKSKSLGDSKNR EEHHHHCCCCCCCCC	44.68	-
264	Methylation	KPKVKKLKYHQYIPP CCCCCCCCCCCCCCC	49.95	-
265	Phosphorylation	PKVKKLKYHQYIPPD CCCCCCCCCCCCCCC	12.46	22817900
278	Phosphorylation	PDQKAEKSPPPMDSA CCCCCCCCCCCCCHH	33.86	27134283
315	Phosphorylation	QQQHRFSYLGMHQAQ HHHHHHHHHHHHHHH	12.45	29759185
347	Phosphorylation	PLSNTPLSPVKNSFS CCCCCCCCCCCCCCC	28.93	24719451
391	Phosphorylation	RIRGLPVSGTKTALM HHCCCCCCCCHHHHH	38.51	28674419
451	Phosphorylation	NGFYHFGSTSSSPPI CCCCCCCCCCCCCCC	24.95	16141410
455	Phosphorylation	HFGSTSSSPPISPAS CCCCCCCCCCCCCCC	34.17	16141410
459	Phosphorylation	TSSSPPISPASSDLS CCCCCCCCCCCCCCC	21.86	16141410
463	Phosphorylation	PPISPASSDLSVAGS CCCCCCCCCCCCCCC	44.68	-
466	Phosphorylation	SPASSDLSVAGSLPD CCCCCCCCCCCCCCC	18.21	26074081
470	Phosphorylation	SDLSVAGSLPDTFND CCCCCCCCCCCCCCC	27.30	26074081
571	Sumoylation	PFLAASIKQEEAVSS HHHHHHHCHHHHHHH	49.51	-
571	Sumoylation	PFLAASIKQEEAVSS HHHHHHHCHHHHHHH	49.51	-
588	Acetylation	FASQVPVKRQSSSSE CHHCCCCCCCCCCCC	38.35	7407611
626	Phosphorylation	DQTNVLSSTFLSPQC CCCCCCCCEECCCCC	21.01	16141410
630	Phosphorylation	VLSSTFLSPQCSPQH CCCCEECCCCCCCCC	14.56	16141410
634	Phosphorylation	TFLSPQCSPQHSPLG EECCCCCCCCCCCCC	23.50	16141410
638	Phosphorylation	PQCSPQHSPLGAVKS CCCCCCCCCCCCCCC	19.30	-
704	Phosphorylation	GPKFSIPSPTFSKSS CCCCCCCCCCCCCCC	34.60	29214152
706	Phosphorylation	KFSIPSPTFSKSSSA CCCCCCCCCCCCCCC	44.90	29449344
708	Phosphorylation	SIPSPTFSKSSSAIS CCCCCCCCCCCCCCH	33.82	29449344
732	Phosphorylation	DAVKQQMTRSQQMDE HHHHHHHHHHHHHHH	23.88	-
734	Phosphorylation	VKQQMTRSQQMDELL HHHHHHHHHHHHHHH	18.65	-
770	Phosphorylation	KVPKIPRSSRSPTAV CCCCCCCCCCCCCEE	25.42	29449344
771	Phosphorylation	VPKIPRSSRSPTAVL CCCCCCCCCCCCEEE	37.75	29449344
773	Phosphorylation	KIPRSSRSPTAVLTK CCCCCCCCCCEEEEC	28.66	29449344
775	Phosphorylation	PRSSRSPTAVLTKPS CCCCCCCCEEEECCC	30.55	29449344
815	Phosphorylation	EVLLNSQSPLGKMSD HHHHCCCCCCCCCCC	23.16	-
862	Phosphorylation	EILPGPLSPMQTQFS HCCCCCCCCCCCCCC	22.81	26074081
866	Phosphorylation	GPLSPMQTQFSPSSV CCCCCCCCCCCCCCC	25.90	26074081
869	Phosphorylation	SPMQTQFSPSSVDSN CCCCCCCCCCCCCCC	17.66	26074081
871	Phosphorylation	MQTQFSPSSVDSNGL CCCCCCCCCCCCCCC	41.62	26074081
872	Phosphorylation	QTQFSPSSVDSNGLQ CCCCCCCCCCCCCCE	33.07	26074081
875	Phosphorylation	FSPSSVDSNGLQLSF CCCCCCCCCCCEEEE	30.55	26074081
881	Phosphorylation	DSNGLQLSFTESPWE CCCCCEEEEECCCCC	19.70	26074081
883	Phosphorylation	NGLQLSFTESPWETM CCCEEEEECCCCCCE	31.98	26074081
885	Phosphorylation	LQLSFTESPWETMEW CEEEEECCCCCCEEE	32.05	26074081
889	Phosphorylation	FTESPWETMEWLDLT EECCCCCCEEECCCC	19.27	26074081
896	Phosphorylation	TMEWLDLTPPNSTPG CEEECCCCCCCCCCC	36.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
451	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
455	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
459	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
463	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
626	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
630	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
634	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
638	S	Phosphorylation	Kinase	GSK3-BETA	P49841	Uniprot
815	S	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
815	S	Phosphorylation	Kinase	MAPK3	P27361	Uniprot
862	S	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
862	S	Phosphorylation	Kinase	MAPK3	P27361	Uniprot
869	S	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
869	S	Phosphorylation	Kinase	MAPK3	P27361	Uniprot
896	T	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
896	T	Phosphorylation	Kinase	MAPK3	P27361	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:19237536

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYCD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYCD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRF_HUMAN	SRF	physical	15014501
MKL1_HUMAN	MKL1	physical	14970199
SMCA4_HUMAN	SMARCA4	physical	19342595
SRF_HUMAN	SRF	physical	19342595
MYOD1_HUMAN	MYOD1	physical	17940050
CHIP_HUMAN	STUB1	physical	19237536
HSP74_HUMAN	HSPA4	physical	19237536
HS90A_HUMAN	HSP90AA1	physical	19237536
NCOA3_HUMAN	NCOA3	physical	17360478
NCOA3_HUMAN	NCOA3	genetic	17360478

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.