SEM4G_HUMAN - dbPTM
SEM4G_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEM4G_HUMAN
UniProt AC Q9NTN9
Protein Name Semaphorin-4G
Gene Name SEMA4G
Organism Homo sapiens (Human).
Sequence Length 838
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)..
Protein Sequence MWGRLWPLLLSILTATAVPGPSLRRPSRELDATPRMTIPYEELSGTRHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTSFEEGKEKCPYDPARGFTGLIIDGGLYTATRYEFRSIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIPLYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSGMHIIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRYRSCYDCILARDPYCGWDPGTHACAAATTIANRTALIQDIERGNRGCESSRDTGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLTVRPATPAPAPKAPATPGAQLAPDVRLLYVLAIAALGGLCLILASSLLYVACLREGRRGRRRKYSLGRASRAGGSAVQLQTVSGQCPGEEDEGDDEGAGGLEGSCLQIIPGEGAPAPPPPPPPPPPAELTNGLVALPSRLRRMNGNSYVLLRQSNNGVPAGPCSFAEELSRILEKRKHTQLVEQLDESSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationGPSLRRPSRELDATP
CCCCCCCCCCCCCCC		36.2523312004
33PhosphorylationPSRELDATPRMTIPY
CCCCCCCCCCCCCCH		15.8723312004
55N-linked_GlycosylationHFKGQAQNYSTLLLE
CCCCCCCCCHHHHHH		35.42UniProtKB CARBOHYD
56PhosphorylationFKGQAQNYSTLLLEE
CCCCCCCCHHHHHHH		7.3129759185
57PhosphorylationKGQAQNYSTLLLEEA
CCCCCCCHHHHHHHH		21.8229759185
58PhosphorylationGQAQNYSTLLLEEAS
CCCCCCHHHHHHHHH		15.8629759185
97PhosphorylationKEIHWEASPEMQSKC
CEEEECCCHHHHHHH		15.1825850435
102PhosphorylationEASPEMQSKCHQKGK
CCCHHHHHHHHHCCC		35.6225850435
111N-linked_GlycosylationCHQKGKNNQTECFNH
HHHCCCCCHHHHHHH		54.35UniProtKB CARBOHYD
126N-linked_GlycosylationVRFLQRLNSTHLYAC
HHHHHHCCCCCEEEC		47.23UniProtKB CARBOHYD
186PhosphorylationGLYTATRYEFRSIPD
CCEEEECEEECCCCC		18.3124043423
240PhosphorylationGDDDKVYYFFTERAT
CCCCEEEEEEEECCC		8.66-
257PhosphorylationGSGSFTQSRSSHRVA
CCCCCCCCCHHHHHH		30.95-
282AcetylationGGKKILQKKWTSFLK
CCHHHHHHHHHHHHH		47.0019818153
286PhosphorylationILQKKWTSFLKARLI
HHHHHHHHHHHHHHH		27.7124719451
330PhosphorylationTLSTQWKTLEASAIC
EEECCCCCHHHHHHH		27.2026552605
334PhosphorylationQWKTLEASAICRYDL
CCCCHHHHHHHCCCH		14.5926552605
339PhosphorylationEASAICRYDLAEIQA
HHHHHHCCCHHHHHH		15.7626552605
352PhosphorylationQAVFAGPYMEYQDGS
HHHHCCCCEECCCCC		11.1426552605
355PhosphorylationFAGPYMEYQDGSRRW
HCCCCEECCCCCCCC		8.7226552605
359PhosphorylationYMEYQDGSRRWGRYE
CEECCCCCCCCCCCC		27.2826552605
388N-linked_GlycosylationSLRSQGYNSSQDLPS
HHHHCCCCCCCCCCH		41.85UniProtKB CARBOHYD
479PhosphorylationQVFRESQSVENLVIS
HHHHCCCCHHHHHHH		40.45-
524 (in isoform 3)Phosphorylation-14.1026552605
524 (in isoform 2)Phosphorylation-14.1026552605
531 (in isoform 3)Phosphorylation-16.2226552605
531 (in isoform 2)Phosphorylation-16.2226552605
538 (in isoform 3)Phosphorylation-17.6326552605
538 (in isoform 2)Phosphorylation-17.6326552605
539 (in isoform 3)Phosphorylation-17.2326552605
539 (in isoform 2)Phosphorylation-17.2326552605
542N-linked_GlycosylationAAATTIANRTALIQD
HHHHHHHHHHHHHHH		37.68UniProtKB CARBOHYD
544 (in isoform 3)Phosphorylation-26.1426552605
544 (in isoform 2)Phosphorylation-26.1426552605
547 (in isoform 2)Phosphorylation-2.9926552605
547 (in isoform 3)Phosphorylation-2.9926552605
598N-linked_GlycosylationARALWLLNGSMGLSD
HHHHHHHHCCCCCCC		38.02UniProtKB CARBOHYD
713PhosphorylationRGRRRKYSLGRASRA
CCCCCCCHHCCHHHC		27.6422798277
723PhosphorylationRASRAGGSAVQLQTV
CHHHCCCCCEEEEEE		25.0924275569
795PhosphorylationLRRMNGNSYVLLRQS
HHHHCCCEEEEEEEC		20.3026074081
796PhosphorylationRRMNGNSYVLLRQSN
HHHCCCEEEEEEECC		10.1026074081
836PhosphorylationLVEQLDESSV-----
HHHHHHHCCC-----		35.7528348404
837PhosphorylationVEQLDESSV------
HHHHHHCCC------		29.7828348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEM4G_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEM4G_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEM4G_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SEM4G_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEM4G_HUMAN

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Related Literatures of Post-Translational Modification

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