GRM5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM5_RAT
• UniProt AC: P31424
• Protein Name: Metabotropic glutamate receptor 5
• Gene Name: Grm5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1203
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity..
• Protein Sequence: MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	N-linked_Glycosylation	SDPTLLPNITLGCEI CCCCCCCCCEECCEE	39.59	-
209	N-linked_Glycosylation	VDIVKRYNWTYVSAV HHHHHHCCCEEEEEE	28.75	-
377	N-linked_Glycosylation	AQENSKYNKTCNSSL HHCCHHCCCCCCCCC	36.58	-
381	N-linked_Glycosylation	SKYNKTCNSSLTLRT HHCCCCCCCCCEEEE	39.61	-
444	N-linked_Glycosylation	LDSLMKTNFTGVSGD HHHHHHCCCCCCCCC	27.28	-
733	N-linked_Glycosylation	REVYLICNTTNLGVV CEEEEEECCCCCCCC	42.83	-
800	Phosphorylation	GSNYKIITMCFSVSL CCCCEEEEECEECCH	16.03	24945867
804	Phosphorylation	KIITMCFSVSLSATV EEEEECEECCHHHHH	13.08	24945867
806	Phosphorylation	ITMCFSVSLSATVAL EEECEECCHHHHHHH	18.53	24945867
808	Phosphorylation	MCFSVSLSATVALGC ECEECCHHHHHHHHC	17.87	24945867
810	Phosphorylation	FSVSLSATVALGCMF EECCHHHHHHHHCCC	11.70	24945867
837	Phosphorylation	RNVRSAFTTSTVVRM CCHHHCCEECEEEEE	21.39	27097102
838	Phosphorylation	NVRSAFTTSTVVRMH CHHHCCEECEEEEEE	18.88	27097102
839	Phosphorylation	VRSAFTTSTVVRMHV HHHCCEECEEEEEEE	19.02	27097102
840	Phosphorylation	RSAFTTSTVVRMHVG HHCCEECEEEEEEEC	22.41	27097102
851	Phosphorylation	MHVGDGKSSSAASRS EEECCCCCCCCHHHC	34.75	27097102
852	Phosphorylation	HVGDGKSSSAASRSS EECCCCCCCCHHHCH	27.73	27097102
853	Phosphorylation	VGDGKSSSAASRSSS ECCCCCCCCHHHCHH	34.64	27097102
856	Phosphorylation	GKSSSAASRSSSLVN CCCCCCHHHCHHHHH	32.20	27097102
858	Phosphorylation	SSSAASRSSSLVNLW CCCCHHHCHHHHHHH	23.06	27097102
859	Phosphorylation	SSAASRSSSLVNLWK CCCHHHCHHHHHHHH	26.95	27097102
860	Phosphorylation	SAASRSSSLVNLWKR CCHHHCHHHHHHHHH	37.27	27097102
868	Methylation	LVNLWKRRGSSGETL HHHHHHHCCCCCCHH	45.69	-
870	Phosphorylation	NLWKRRGSSGETLRY HHHHHCCCCCCHHHH	33.10	25403869
893	Phosphorylation	KSEIECFTPKGSMGN CCEEEEECCCCCCCC	35.43	18779572
913	Phosphorylation	MSSSNGKSVTWAQNE EECCCCCCCEEEECC	26.61	27097102
915	Phosphorylation	SSNGKSVTWAQNEKS CCCCCCCEEEECCCC	23.36	27097102
924	Methylation	AQNEKSTRGQHLWQR EECCCCCCHHHHHHH	50.28	-
933	Phosphorylation	QHLWQRLSVHINKKE HHHHHHHHEEECCCC	17.53	25403869
1014	Phosphorylation	PAAARPRSPSPISTL CCCCCCCCCCCHHHH	32.20	30411139
1016	Phosphorylation	AARPRSPSPISTLSH CCCCCCCCCHHHHHH	35.79	30411139
1019	Phosphorylation	PRSPSPISTLSHLAG CCCCCCHHHHHHHHC	27.04	28551015
1020	Phosphorylation	RSPSPISTLSHLAGS CCCCCHHHHHHHHCC	32.76	27097102
1022	Phosphorylation	PSPISTLSHLAGSAG CCCHHHHHHHHCCCC	19.28	28551015
1027	Phosphorylation	TLSHLAGSAGRTDDD HHHHHHCCCCCCCCC	23.18	28551015
1037	Phosphorylation	RTDDDAPSLHSETAA CCCCCCCCCCCHHHH	40.20	30240740
1040	Phosphorylation	DDAPSLHSETAARSS CCCCCCCCHHHHHCC	41.77	30240740
1046	Phosphorylation	HSETAARSSSSQGSL CCHHHHHCCCCCCCH	29.82	27097102
1047	Phosphorylation	SETAARSSSSQGSLM CHHHHHCCCCCCCHH	28.58	27097102
1048	Phosphorylation	ETAARSSSSQGSLME HHHHHCCCCCCCHHH	28.11	27097102
1049	Phosphorylation	TAARSSSSQGSLMEQ HHHHCCCCCCCHHHH	40.27	27097102
1052	Phosphorylation	RSSSSQGSLMEQISS HCCCCCCCHHHHHHH	19.53	27097102
1158	Phosphorylation	LVALTPPSPFRDSVD HHCCCCCCCCCCCCC	37.56	-
1163	Phosphorylation	PPSPFRDSVDSGSTT CCCCCCCCCCCCCCC	24.46	27097102
1166	Phosphorylation	PFRDSVDSGSTTPNS CCCCCCCCCCCCCCC	32.27	27097102
1168	Phosphorylation	RDSVDSGSTTPNSPV CCCCCCCCCCCCCCC	32.81	27097102
1169	Phosphorylation	DSVDSGSTTPNSPVS CCCCCCCCCCCCCCC	50.20	27097102
1170	Phosphorylation	SVDSGSTTPNSPVSE CCCCCCCCCCCCCCC	23.36	27097102
1173	Phosphorylation	SGSTTPNSPVSESAL CCCCCCCCCCCCCCE	28.07	27097102
1176	Phosphorylation	TTPNSPVSESALCIP CCCCCCCCCCCEECC	29.26	27097102
1178	Phosphorylation	PNSPVSESALCIPSS CCCCCCCCCEECCCC	21.02	27097102
1184	Phosphorylation	ESALCIPSSPKYDTL CCCEECCCCCCCCEE	39.08	27097102
1185	Phosphorylation	SALCIPSSPKYDTLI CCEECCCCCCCCEEE	21.76	27097102
1196	Phosphorylation	DTLIIRDYTQSSSSL CEEEEEECCCCCCCC	9.24	28551015
1197	Phosphorylation	TLIIRDYTQSSSSL- EEEEEECCCCCCCC-	26.68	28551015
1201	Phosphorylation	RDYTQSSSSL----- EECCCCCCCC-----	40.69	28551015
1202	Phosphorylation	DYTQSSSSL------ ECCCCCCCC------	39.79	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
839	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
839	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
839	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
839	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
839	S	Phosphorylation	Kinase	PRKCH	P24723	GPS
839	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
839	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
933	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM5_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	19860857
SIAH1_RAT	Siah1	physical	10469171

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.