DHRS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHRS2_HUMAN
• UniProt AC: Q13268
• Protein Name: Dehydrogenase/reductase SDR family member 2, mitochondrial
• Gene Name: DHRS2
• Organism: Homo sapiens (Human).
• Sequence Length: 280
• Subcellular Localization: Mitochondrion matrix. Nucleus. A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
• Protein Description: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21..
• Protein Sequence: MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	SSTGIDRKGVLANRV HCCCCCCCCCEECCE	6.26	-
42	Phosphorylation	ANRVAVVTGSTSGIG ECCEEEEECCCCHHH	2.23	27251275
44	Phosphorylation	RVAVVTGSTSGIGFA CEEEEECCCCHHHHH	16.69	27251275
45	Phosphorylation	VAVVTGSTSGIGFAI EEEEECCCCHHHHHH	32.16	28102081
45 (in isoform 2)	Phosphorylation	-	32.16	27251275
46	Phosphorylation	AVVTGSTSGIGFAIA EEEECCCCHHHHHHH	33.73	28102081
66	Phosphorylation	DGAHVVISSRKQQNV CCCEEEEECCCHHCH	9.91	27251275
67	Phosphorylation	GAHVVISSRKQQNVD CCEEEEECCCHHCHH	15.65	24719451
67 (in isoform 2)	Phosphorylation	-	15.65	27251275
79	Acetylation	NVDRAMAKLQGEGLS CHHHHHHHHHCCCEE	61.66	25953088
86 (in isoform 2)	Phosphorylation	-	4.56	27251275
86	Phosphorylation	KLQGEGLSVAGIVCH HHHCCCEEEEEEEEE	4.56	27251275
96	Acetylation	GIVCHVGKAEDREQL EEEEEECCCCCHHHH	2.15	23236377
96	Succinylation	GIVCHVGKAEDREQL EEEEEECCCCCHHHH	2.15	-
96	Succinylation	GIVCHVGKAEDREQL EEEEEECCCCCHHHH	2.15	-
130	Ubiquitination	VNPLVGSTLGTSEQI CCCCCCCCCCCHHHH	4.74	23000965
143	Ubiquitination	QIWDKILSVNVKSPA HHHHHHHCCCCCCHH	22.43	23000965
148	Ubiquitination	ILSVNVKSPALLLSQ HHCCCCCCHHHHHHH	2.64	21890473
154	Phosphorylation	KSPALLLSQLLPYME CCHHHHHHHHHHHHC	15.81	22210691
158	Ubiquitination	LLLSQLLPYMENRRG HHHHHHHHHHCCCCC	3.72	21890473
161	Ubiquitination	SQLLPYMENRRGAVI HHHHHHHCCCCCEEE	15.32	23000965
196	Phosphorylation	KTALLGLTRTLALEL HHHHHHHHHHHHHHH	4.94	19664995
206	2-Hydroxyisobutyrylation	LALELAPKDIRVNCV HHHHHCCCCCEECEE	28.30	-
206	Ubiquitination	LALELAPKDIRVNCV HHHHHCCCCCEECEE	28.30	23000965
206	Succinylation	LALELAPKDIRVNCV HHHHHCCCCCEECEE	28.30	23954790
206	Acetylation	LALELAPKDIRVNCV HHHHHCCCCCEECEE	28.30	23236377
219	Succinylation	CVVPGIIKTDFSKVF EEECCEEECCHHHHH	40.99	-
219	Acetylation	CVVPGIIKTDFSKVF EEECCEEECCHHHHH	40.99	23236377
219	Succinylation	CVVPGIIKTDFSKVF EEECCEEECCHHHHH	40.99	-
219	Ubiquitination	CVVPGIIKTDFSKVF EEECCEEECCHHHHH	40.99	23000965
223	Phosphorylation	GIIKTDFSKVFHGNE CEEECCHHHHHCCCH	4.65	-
224	Ubiquitination	IIKTDFSKVFHGNES EEECCHHHHHCCCHH	34.27	21890473
224 (in isoform 1)	Ubiquitination	-	34.27	21890473
224	Acetylation	IIKTDFSKVFHGNES EEECCHHHHHCCCHH	34.27	22424773
231	Phosphorylation	KVFHGNESLWKNFKE HHHCCCHHHHHHHHH	27.45	30266825
234	Ubiquitination	HGNESLWKNFKEHHQ CCCHHHHHHHHHHHH	15.58	21890473
234	Acetylation	HGNESLWKNFKEHHQ CCCHHHHHHHHHHHH	15.58	23236377
234 (in isoform 1)	Ubiquitination	-	15.58	21890473
237	Succinylation	ESLWKNFKEHHQLQR HHHHHHHHHHHHHHH	5.38	-
237	Succinylation	ESLWKNFKEHHQLQR HHHHHHHHHHHHHHH	5.38	-
237	Ubiquitination	ESLWKNFKEHHQLQR HHHHHHHHHHHHHHH	5.38	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHRS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHRS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHRS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	20547751
TCEA2_HUMAN	TCEA2	physical	21988832
ZHX2_HUMAN	ZHX2	physical	21988832
EXOS5_HUMAN	EXOSC5	physical	21988832
APBP2_HUMAN	APPBP2	physical	25416956
HBB_HUMAN	HBB	physical	26186194
HBB_HUMAN	HBB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.