MIC27_HUMAN - dbPTM
MIC27_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MIC27_HUMAN
UniProt AC Q6UXV4
Protein Name MICOS complex subunit MIC27
Gene Name APOOL
Organism Homo sapiens (Human).
Sequence Length 268
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein . Mitochondrion .
Protein Description Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. [PubMed: 23704930),]
Protein Sequence MAAIRMGKLTTMPAGLIYASVSVHAAKQEESKKQLVKPEQLPIYTAPPLQSKYVEEQPGHLQMGFASIRTATGCYIGWCKGVYVFVKNGIMDTVQFGKDAYVYLKNPPRDFLPKMGVITVSGLAGLVSARKGSKFKKITYPLGLATLGATVCYPVQSVIIAKVTAKKVYATSQQIFGAVKSLWTKSSKEESLPKPKEKTKLGSSSEIEVPAKTTHVLKHSVPLPTELSSEAKTKSESTSGATQFMPDPKLMDHGQSHPEDIDMYSTRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationAIRMGKLTTMPAGLI
CCCCCCCCCCCCCCE		23401153
11PhosphorylationIRMGKLTTMPAGLIY
CCCCCCCCCCCCCEE		23401153
18PhosphorylationTMPAGLIYASVSVHA
CCCCCCEEEEHHHHH		22210691
20PhosphorylationPAGLIYASVSVHAAK
CCCCEEEEHHHHHHC		22210691
31PhosphorylationHAAKQEESKKQLVKP
HHHCHHHHHHHCCCH		22210691
33UbiquitinationAKQEESKKQLVKPEQ
HCHHHHHHHCCCHHH		-
33MalonylationAKQEESKKQLVKPEQ
HCHHHHHHHCCCHHH		32601280
44PhosphorylationKPEQLPIYTAPPLQS
CHHHCCCEECCCCCC		27642862
45PhosphorylationPEQLPIYTAPPLQSK
HHHCCCEECCCCCCC		26437602
51PhosphorylationYTAPPLQSKYVEEQP
EECCCCCCCCCCCCC		24641631
101PhosphorylationVQFGKDAYVYLKNPP
EECCCCEEEEECCCC		-
121PhosphorylationKMGVITVSGLAGLVS
CCCEEEEEHHHHHHH		17081983
186PhosphorylationVKSLWTKSSKEESLP
HHHHHCCCCCCCCCC		26437602
187PhosphorylationKSLWTKSSKEESLPK
HHHHCCCCCCCCCCC		26437602
199PhosphorylationLPKPKEKTKLGSSSE
CCCCCCCCCCCCCCC		28450419
203PhosphorylationKEKTKLGSSSEIEVP
CCCCCCCCCCCEECC		29255136
204PhosphorylationEKTKLGSSSEIEVPA
CCCCCCCCCCEECCC		25849741
205PhosphorylationKTKLGSSSEIEVPAK
CCCCCCCCCEECCCC		29255136
212MalonylationSEIEVPAKTTHVLKH
CCEECCCCCCEEEEC		26320211
213PhosphorylationEIEVPAKTTHVLKHS
CEECCCCCCEEEECC		23312004
214PhosphorylationIEVPAKTTHVLKHSV
EECCCCCCEEEECCC		23312004
218MalonylationAKTTHVLKHSVPLPT
CCCCEEEECCCCCCC		26320211
220PhosphorylationTTHVLKHSVPLPTEL
CCEEEECCCCCCCCC		-
225PhosphorylationKHSVPLPTELSSEAK
ECCCCCCCCCCCCCC		23312004
228PhosphorylationVPLPTELSSEAKTKS
CCCCCCCCCCCCCCC		23312004
229PhosphorylationPLPTELSSEAKTKSE
CCCCCCCCCCCCCCC		23312004
232MalonylationTELSSEAKTKSESTS
CCCCCCCCCCCCCCC		32601280
233PhosphorylationELSSEAKTKSESTSG
CCCCCCCCCCCCCCC		23312004
235PhosphorylationSSEAKTKSESTSGAT
CCCCCCCCCCCCCCC		23312004
237PhosphorylationEAKTKSESTSGATQF
CCCCCCCCCCCCCCC		23312004
238PhosphorylationAKTKSESTSGATQFM
CCCCCCCCCCCCCCC		23312004
239PhosphorylationKTKSESTSGATQFMP
CCCCCCCCCCCCCCC		23312004
242PhosphorylationSESTSGATQFMPDPK
CCCCCCCCCCCCCHH		23312004
245SulfoxidationTSGATQFMPDPKLMD
CCCCCCCCCCHHHHC		21406390
256PhosphorylationKLMDHGQSHPEDIDM
HHHCCCCCCHHHCCC		25159151
266PhosphorylationEDIDMYSTRS-----
HHCCCCCCCC-----		22210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MIC27_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MIC27_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MIC27_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DJC11_HUMANDNAJC11physical
27499296
MIC27_HUMANAPOOLphysical
27499296
MTX2_HUMANMTX2physical
27499296
MIC25_HUMANCHCHD6physical
27499296
RMD3_HUMANRMDN3physical
27499296
MIC19_HUMANCHCHD3physical
27499296
SAM50_HUMANSAMM50physical
27499296
STAR7_HUMANSTARD7physical
27499296
NRDC_HUMANNRD1physical
27499296
MTX1_HUMANMTX1physical
27499296
MIC60_HUMANIMMTphysical
27499296
STML2_HUMANSTOML2physical
27499296
COX6C_HUMANCOX6Cphysical
27499296
YMEL1_HUMANYME1L1physical
27499296
MPPA_HUMANPMPCAphysical
27499296
COASY_HUMANCOASYphysical
27499296
ATP5E_HUMANATP5Ephysical
27499296
ATPO_HUMANATP5Ophysical
27499296
ATP5H_HUMANATP5Hphysical
27499296
ATP5I_HUMANATP5Iphysical
27499296
ECH1_HUMANECH1physical
27499296
DDAH1_HUMANDDAH1physical
27499296
TIM44_HUMANTIMM44physical
27499296
NDUBB_HUMANNDUFB11physical
27499296
CHCH2_HUMANCHCHD2physical
27499296
SFXN1_HUMANSFXN1physical
27499296
MIRO1_HUMANRHOT1physical
27499296
QCR7_HUMANUQCRBphysical
27499296
MIC26_HUMANAPOOphysical
27499296
MTCH2_HUMANMTCH2physical
27499296
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MIC27_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory