PHAR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHAR1_HUMAN
• UniProt AC: Q9C0D0
• Protein Name: Phosphatase and actin regulator 1
• Gene Name: PHACTR1
• Organism: Homo sapiens (Human).
• Sequence Length: 580
• Subcellular Localization: Cytoplasm. Cell junction, synapse. Nucleus. Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity)..
• Protein Description: Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival..
• Protein Sequence: MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	RPIRRVRSKSDTPYL CCCHHCCCCCCCCCE	33.38	27732954
67	Phosphorylation	IRRVRSKSDTPYLAE CHHCCCCCCCCCEEE	48.22	25307156
69	Phosphorylation	RVRSKSDTPYLAEAR HCCCCCCCCCEEEEH	22.41	27732954
78	Phosphorylation	YLAEARISFNLGAAE CEEEEHHEECCCCHH	11.52	27251275
95	Phosphorylation	ERLAAMRSDSLVPGT HHHHHHCCCCCCCCC	20.61	28857561
97	Phosphorylation	LAAMRSDSLVPGTHT HHHHCCCCCCCCCCC	32.29	28857561
102	Phosphorylation	SDSLVPGTHTPPIRR CCCCCCCCCCCCCCC	19.26	28857561
104	Phosphorylation	SLVPGTHTPPIRRRS CCCCCCCCCCCCCCH	30.51	20886841
145	Phosphorylation	AALERKISMRQSREE HHHHHHHHHHHCHHH	15.79	24719451
149	Phosphorylation	RKISMRQSREELIKR HHHHHHHCHHHHHHC	31.15	21712546
237	Phosphorylation	PCLPVKLSPPLPPKK CEEECCCCCCCCCCE	20.82	22985185
467	Phosphorylation	TKLTRRLSQRPTAEE HHHHHHHHCCCCHHH	23.49	22777824
471	Phosphorylation	RRLSQRPTAEELEQR HHHHCCCCHHHHHHC	49.22	23186163
501	Phosphorylation	REIKRRLTRKLSQRP HHHHHHHHHHHHCCC	24.77	-
505	Phosphorylation	RRLTRKLSQRPTVEE HHHHHHHHCCCCHHH	27.46	23401153
509	Phosphorylation	RKLSQRPTVEELRER HHHHCCCCHHHHHHC	42.62	29255136
525	Phosphorylation	ILIRFSDYVEVADAQ EEEECHHCEEECCHH	9.41	30257219
562	Phosphorylation	KELNEFKSTEMEVHE HHHHHHHCCHHHHHH	34.61	29083192
563	Phosphorylation	ELNEFKSTEMEVHEL HHHHHHCCHHHHHHH	39.68	29083192
571	Phosphorylation	EMEVHELSRHLTRFH HHHHHHHHHHHHHHC	18.05	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHAR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHAR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHAR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTS_HUMAN	ACTA1	physical	15107502
PP1A_HUMAN	PPP1CA	physical	15107502

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.