JPH3_HUMAN - dbPTM
JPH3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JPH3_HUMAN
UniProt AC Q8WXH2
Protein Name Junctophilin-3
Gene Name JPH3
Organism Homo sapiens (Human).
Sequence Length 748
Subcellular Localization Cell membrane
Peripheral membrane protein. Endoplasmic reticulum membrane
Single-pass type IV membrane protein. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-term
Protein Description Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory..
Protein Sequence MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASPAVAGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCDDIEVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHRASNHSPGGSRLLELQEEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMVILLNIGVAILFINFFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationRHGIGLESKGKWVYK
CCCEECEECCEEEEC		52.32-
112PhosphorylationAKYEGTWSNGLQDGY
CCEEEECCCCCCCCC		22.3630576142
124PhosphorylationDGYGTETYSDGGTYQ
CCCCCEECCCCCEEE		9.8730576142
147PhosphorylationQGYGVRQSVPYGMAA
CCCCCCCCCCCCCCH		17.9422210691
158PhosphorylationGMAAVIRSPLRTSIN
CCCHHHCCHHHHHHH		19.7022210691
162PhosphorylationVIRSPLRTSINSLRS
HHCCHHHHHHHHHHC		41.4622210691
163PhosphorylationIRSPLRTSINSLRSE
HCCHHHHHHHHHHCC		17.2230266825
166PhosphorylationPLRTSINSLRSEHTN
HHHHHHHHHHCCCCC		24.4022210691
228PhosphorylationSGLKLRKSESKSSLA
HCCCCCCCCCHHHHH		40.44-
230PhosphorylationLKLRKSESKSSLASQ
CCCCCCCCHHHHHHH		44.95-
232PhosphorylationLRKSESKSSLASQRS
CCCCCCHHHHHHHHH		39.60-
233PhosphorylationRKSESKSSLASQRSK
CCCCCHHHHHHHHHH		31.52-
317PhosphorylationKYEGEWASNRRHGYG
EECCEECCCCCCCEE		31.7628509920
338PhosphorylationGTKEEGKYKQNILVG
CCCCCCCCCEEEEEC		28.7622817900
415PhosphorylationEARIARITAKEFSPS
HHHHHHHHHHHCCCH		26.56-
420PhosphorylationRITAKEFSPSFQHRE
HHHHHHCCCHHHCHH		22.2630266825
422PhosphorylationTAKEFSPSFQHRENG
HHHHCCCHHHCHHCC		36.0230266825
439PhosphorylationYQRPKRQTSCDDIEV
CCCCCCCCCCCCEEE		35.0426471730
440PhosphorylationQRPKRQTSCDDIEVL
CCCCCCCCCCCEEEC		13.7626471730
448PhosphorylationCDDIEVLSTGTPLQQ
CCCEEECCCCCCCCC		29.9326471730
451PhosphorylationIEVLSTGTPLQQESP
EEECCCCCCCCCCCH		22.40-
457PhosphorylationGTPLQQESPELYRKG
CCCCCCCCHHHHHCC		21.2426471730
461PhosphorylationQQESPELYRKGTTPS
CCCCHHHHHCCCCHH		14.4926471730
465PhosphorylationPELYRKGTTPSDLTP
HHHHHCCCCHHHCCC		38.2723312004
466PhosphorylationELYRKGTTPSDLTPD
HHHHCCCCHHHCCCC		29.4823312004
468PhosphorylationYRKGTTPSDLTPDDS
HHCCCCHHHCCCCCC		43.0623312004
471PhosphorylationGTTPSDLTPDDSPLQ
CCCHHHCCCCCCCCC		29.6623312004
475PhosphorylationSDLTPDDSPLQSFPT
HHCCCCCCCCCCCCC		34.5823312004
479PhosphorylationPDDSPLQSFPTSPAA
CCCCCCCCCCCCCCC		40.6623312004
482PhosphorylationSPLQSFPTSPAATPP
CCCCCCCCCCCCCCC		45.3823312004
483PhosphorylationPLQSFPTSPAATPPP
CCCCCCCCCCCCCCC		16.8723312004
487PhosphorylationFPTSPAATPPPAPAA
CCCCCCCCCCCCCHH		38.1323312004
506PhosphorylationAHFSRQVSVDEERGG
HEEEEECCCCHHCCC		18.6029449344
544PhosphorylationGGSRGVRSGALRGGL
CCCCCCCCCCCCCCE		26.4725404012
548MethylationGVRSGALRGGLLVDD
CCCCCCCCCCEECCC		36.28115480757
611PhosphorylationQEEKLSNYRMEMKPL
HHHHHHCCCHHHHHH		14.15-
669PhosphorylationKENFRPASSAEPAVQ
HHCCCCCCCCCHHHH		32.5330266825
670PhosphorylationENFRPASSAEPAVQK
HCCCCCCCCCHHHHH		38.4630266825
680PhosphorylationPAVQKLASLRLGGAE
HHHHHHHHCCCCCCC		25.1824719451
703PhosphorylationTFSPPQKSLPVALES
ECCCCCCCCCEEEEC		32.43-
710PhosphorylationSLPVALESDEENGDE
CCCEEEECCCCCCCH		51.6930266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JPH3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JPH3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JPH3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of JPH3_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JPH3_HUMAN

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Related Literatures of Post-Translational Modification

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