LMTK1_HUMAN - dbPTM
LMTK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LMTK1_HUMAN
UniProt AC Q6ZMQ8
Protein Name Serine/threonine-protein kinase LMTK1
Gene Name AATK
Organism Homo sapiens (Human).
Sequence Length 1374
Subcellular Localization Membrane
Single-pass type I membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Predominantly perinuclear.
Protein Description May be involved in neuronal differentiation..
Protein Sequence MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLARDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEPKLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPRAPLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
57AcetylationLACLCCKKGGIGFKE
HHHHHHHHCCCCCEE		48.7524168699
222PhosphorylationRSCRVAESMAPDPRT
HHHHHHHHCCCCHHH		15.54-
283PhosphorylationHCKYREDYFVTADQL
CCEECCCEEEEHHHE		8.66-
286PhosphorylationYREDYFVTADQLWVP
ECCCEEEEHHHEEEE		18.02-
434 (in isoform 2)Phosphorylation-5.4827174698
479PhosphorylationSRGLNFEYKWEAGRG
CCCCCCEEEEECCCC		19.77-
493PhosphorylationGAEAFPATLSPGRTA
CCCCCCCCCCCCCCH		28.1828450419
495PhosphorylationEAFPATLSPGRTARL
CCCCCCCCCCCCHHH		22.4323927012
520PhosphorylationPGVVPVLSAHSPSLG
CCCEEEEEECCCCCC		24.9525627689
523PhosphorylationVPVLSAHSPSLGSEY
EEEEEECCCCCCCCE		18.8525627689
700PhosphorylationPESWDPVSAGGHAEG
CCCCCCCCCCCCCCC		26.9520873877
710PhosphorylationGHAEGCPSPKQTPRA
CCCCCCCCCCCCCCC		49.1320873877
714PhosphorylationGCPSPKQTPRASPEP
CCCCCCCCCCCCCCC		22.3720873877
826PhosphorylationAPDALPDSPTPATGG
CCCCCCCCCCCCCCC		28.8226471730
828PhosphorylationDALPDSPTPATGGEV
CCCCCCCCCCCCCCH		29.5226471730
831PhosphorylationPDSPTPATGGEVSAI
CCCCCCCCCCCHHHH		47.0926471730
836PhosphorylationPATGGEVSAIKLASA
CCCCCCHHHHHHHHH		21.7026471730
867 (in isoform 3)Phosphorylation-20.9927174698
941PhosphorylationALDSGYDTENYESPE
CCCCCCCCCCCCCCH		20.0422817900
946PhosphorylationYDTENYESPEFVLKE
CCCCCCCCCHHHHHH		21.2625159151
968PhosphorylationQAFAELASEGEGPGP
HHHHHHHHCCCCCCC		59.7725159151
981PhosphorylationGPETRLSTSLSGLNE
CCCCCCCCCCCCCCC		37.9725627689
999PhosphorylationYRDSAYFSDLEAEAE
CCCCCCCCCHHHHHH		28.7225159151
1029PhosphorylationGPELGLPSTGQPSEQ
CCCCCCCCCCCCCCC		50.65-
1168PhosphorylationEEEDSEDSDESDEEL
HCCCCCCCCCCHHHH		38.95-
1171PhosphorylationDSEDSDESDEELRCY
CCCCCCCCHHHHHEE		56.14-
1184PhosphorylationCYSVQEPSEDSEEEA
EEECCCCCCCCCCCC		53.97-
1187PhosphorylationVQEPSEDSEEEAPAV
CCCCCCCCCCCCCCC		42.74-
1209PhosphorylationQSARNLRSLLKMPSL
HHHHHHHHHHCCHHH		41.0224719451
1215PhosphorylationRSLLKMPSLLSETFC
HHHHCCHHHHHHHHH		38.1428450419
1218PhosphorylationLKMPSLLSETFCEDL
HCCHHHHHHHHHHHH		39.6228450419
1220PhosphorylationMPSLLSETFCEDLER
CHHHHHHHHHHHHHH		30.1528450419
1260AcetylationGEPFPGAKESPPTFL
CCCCCCCCCCCCCCC		65.7230589891
1262PhosphorylationPFPGAKESPPTFLRG
CCCCCCCCCCCCCCC		35.1621815630
1308PhosphorylationDDDFPLMTAKAAFAM
CCCCCCCCHHHHHHH		32.4624719451
1340PhosphorylationPFSRFTVSPAPTSRF
CCCCEEECCCCCCCC		16.5825159151
1344PhosphorylationFTVSPAPTSRFSITH
EEECCCCCCCCEEEE		34.34-
1345PhosphorylationTVSPAPTSRFSITHV
EECCCCCCCCEEEEE		30.2130576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LMTK1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LMTK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LMTK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTC_HUMANACTC1physical
25852190
ATD3A_HUMANATAD3Aphysical
25852190
DNJA1_HUMANDNAJA1physical
25852190
DNJA3_HUMANDNAJA3physical
25852190
DPM1_HUMANDPM1physical
25852190
HSPB1_HUMANHSPB1physical
25852190
P4HA1_HUMANP4HA1physical
25852190
PP1A_HUMANPPP1CAphysical
25852190
PP1G_HUMANPPP1CCphysical
25852190
RCN1_HUMANRCN1physical
25852190
TXTP_HUMANSLC25A1physical
25852190
M2OM_HUMANSLC25A11physical
25852190
CMC1_HUMANSLC25A12physical
25852190
CMC2_HUMANSLC25A13physical
25852190
GHC1_HUMANSLC25A22physical
25852190
SSRD_HUMANSSR4physical
25852190
PP1A_HUMANPPP1CAphysical
28065597
PP1B_HUMANPPP1CBphysical
28065597
PP1G_HUMANPPP1CCphysical
28065597
PP2BA_HUMANPPP3CAphysical
28065597
PP2BB_HUMANPPP3CBphysical
28065597
PPM1A_HUMANPPM1Aphysical
28065597
PPM1B_HUMANPPM1Bphysical
28065597
PPM1F_HUMANPPM1Fphysical
28065597
PPM1K_HUMANPPM1Kphysical
28065597
PPM1M_HUMANPPM1Mphysical
28065597
ILKAP_HUMANILKAPphysical
28065597
TAB1_HUMANTAB1physical
28065597
PTPRR_HUMANPTPRRphysical
28065597
PTN6_HUMANPTPN6physical
28065597
PTN7_HUMANPTPN7physical
28065597
PTN11_HUMANPTPN11physical
28065597
PTN12_HUMANPTPN12physical
28065597
PTN18_HUMANPTPN18physical
28065597
PTN20_HUMANPTPN20Bphysical
28065597
DUS1_HUMANDUSP1physical
28065597
DUS5_HUMANDUSP5physical
28065597
DUS6_HUMANDUSP6physical
28065597
DUS9_HUMANDUSP9physical
28065597
DUS14_HUMANDUSP14physical
28065597
DUPD1_HUMANDUPD1physical
28065597
STYX_HUMANSTYXphysical
28065597
CC14A_HUMANCDC14Aphysical
28065597
PTPC1_HUMANPTPDC1physical
28065597
PTEN_HUMANPTENphysical
28065597
TPTE2_HUMANTPTE2physical
28065597
MTMR5_HUMANSBF1physical
28065597
MTMR6_HUMANMTMR6physical
28065597
MTMR8_HUMANMTMR8physical
28065597
MTMR9_HUMANMTMR9physical
28065597
MTMRA_HUMANMTMR10physical
28065597
MPIP2_HUMANCDC25Bphysical
28065597
EYA2_HUMANEYA2physical
28065597
EYA4_HUMANEYA4physical
28065597
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LMTK1_HUMAN

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Related Literatures of Post-Translational Modification

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