PTN20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTN20_HUMAN
• UniProt AC: Q4JDL3
• Protein Name: Tyrosine-protein phosphatase non-receptor type 20
• Gene Name: PTPN20 {ECO:0000312|HGNC:HGNC:23423}
• Organism: Homo sapiens (Human).
• Sequence Length: 420
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with the microtubule-organizing center and intracellular membrane compartments.
• Protein Description: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates..
• Protein Sequence: MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKVFENKVNSEKVKLSLRNFPHNDYEDVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAAGPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLTLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	NSEKVKLSLRNFPHN CHHHHEEECCCCCCC	21.40	24719451
76	Phosphorylation	VFEEPSESGSDPSMW HHCCCCCCCCCCHHC	48.19	-
84 (in isoform 5)	Phosphorylation	-	9.61	24275569
86 (in isoform 5)	Phosphorylation	-	46.04	24275569
86 (in isoform 15)	Phosphorylation	-	46.04	29978859
87 (in isoform 15)	Phosphorylation	-	24.20	29978859
95	Phosphorylation	PFRRDRWSSEDEEAA CCCCCCCCCCCHHHC	25.41	30624053
95 (in isoform 13)	Phosphorylation	-	25.41	29978859
96 (in isoform 15)	Phosphorylation	-	41.95	29978859
96	Phosphorylation	FRRDRWSSEDEEAAG CCCCCCCCCCHHHCC	41.95	17525332
96 (in isoform 13)	Phosphorylation	-	41.95	29978859
100 (in isoform 15)	Phosphorylation	-	57.02	29978859
104 (in isoform 15)	Phosphorylation	-	20.67	29978859
105	Phosphorylation	DEEAAGPSQALSPLL CHHHCCCCHHHHHHH	27.45	17525332
105 (in isoform 13)	Phosphorylation	-	27.45	29978859
109	Phosphorylation	AGPSQALSPLLSDTR CCCCHHHHHHHHCHH	19.27	30624053
109 (in isoform 13)	Phosphorylation	-	19.27	29978859
110 (in isoform 15)	Phosphorylation	-	37.86	29978859
111 (in isoform 15)	Phosphorylation	-	6.85	29978859
113	Phosphorylation	QALSPLLSDTRKIVS HHHHHHHHCHHHHCC	44.62	30624053
113 (in isoform 13)	Phosphorylation	-	44.62	29978859
119 (in isoform 13)	Phosphorylation	-	4.83	29978859
120 (in isoform 13)	Phosphorylation	-	43.27	29978859
120	Phosphorylation	SDTRKIVSEGELDQL HCHHHHCCCCCHHHH	43.27	22468782
154	Phosphorylation	LKILEEKTAAYDIMQ HHHHHHHHHHHHHHH	21.57	-
156 (in isoform 11)	Phosphorylation	-	14.04	24275569
157	Phosphorylation	LEEKTAAYDIMQEFM HHHHHHHHHHHHHHH	11.98	-
158 (in isoform 11)	Phosphorylation	-	25.75	24275569
169	Acetylation	EFMALELKNLPGEFN HHHHHHHHCCCCCCC	47.25	7677739
205	Phosphorylation	TRVPLGKSKDYINAS CCCCCCCCCCCCCCE	29.03	28509920
208	Phosphorylation	PLGKSKDYINASYIR CCCCCCCCCCCEEEE	10.38	28509920
306	Phosphorylation	MFQVVEKSTGTSHSV HHHHHHHCCCCCCCE	20.68	25278378
307	Phosphorylation	FQVVEKSTGTSHSVK HHHHHHCCCCCCCEE	56.39	25278378
309	Phosphorylation	VVEKSTGTSHSVKQL HHHHCCCCCCCEEEE	24.29	25278378
310	Phosphorylation	VEKSTGTSHSVKQLQ HHHCCCCCCCEEEEE	18.34	25278378
312	Phosphorylation	KSTGTSHSVKQLQFT HCCCCCCCEEEEEEE	30.67	25278378
332	Phosphorylation	GTPASADSFIKYIRY CCCCCHHHHHHHHHH	28.70	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTN20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTN20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTN20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN20_HUMAN	PTPN20B	physical	27880917
G3PT_HUMAN	GAPDHS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.
PubMed: 17525332