DUS5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS5_HUMAN
• UniProt AC: Q16690
• Protein Name: Dual specificity protein phosphatase 5
• Gene Name: DUSP5
• Organism: Homo sapiens (Human).
• Sequence Length: 384
• Subcellular Localization: Nucleus .
• Protein Description: Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1..
• Protein Sequence: MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGPRVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATATSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKVTSLDGR ------CCCCCCCHH	54.97	-
49	Phosphorylation	SLNVNLNSVVLRRAR EEECCCCHHHHHHHC	19.44	-
64	Phosphorylation	GGAVSARYVLPDEAA CCCCEEEEECCCHHH	13.17	28152594
110	Phosphorylation	SAARVVLTSLLACLP HHHHHHHHHHHHHCC	13.01	-
144	Ubiquitination	PECCVDVKPISQEKI CCCEEECCCCCHHHH	31.97	21906983
258	Ubiquitination	CVREKGGKVLVHCEA HHHHCCCEEEEECCC	40.85	-
277	Phosphorylation	SPTICMAYLMKTKQF CHHHHHHHHHHCCCH	4.77	-
287	Ubiquitination	KTKQFRLKEAFDYIK HCCCHHHHHHHHHHH	42.62	29967540
294	Ubiquitination	KEAFDYIKQRRSMVS HHHHHHHHHHHHHCC	31.36	22817900
321	Phosphorylation	ESEILPSTPNPQPPS HHHCCCCCCCCCCCC	25.75	19666109
346	Phosphorylation	IGHLQTLSPDMQGAY HHHHHHCCCCCCCCC	23.42	19666109
376	Phosphorylation	TVSELSRSPVATATS CHHHHHCCCCCCCCC	21.98	19666109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
321	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
321	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
346	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
346	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
376	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
376	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK03_HUMAN	MAPK3	physical	7836374
IPO7_HUMAN	IPO7	physical	27880917
TEX10_HUMAN	TEX10	physical	27880917
COIL_HUMAN	COIL	physical	27880917
DUS5_HUMAN	DUSP5	physical	27432908
RL32_HUMAN	RPL32	physical	27432908
LZTS2_HUMAN	LZTS2	physical	27432908
RS15_HUMAN	RPS15	physical	27432908
FBX11_HUMAN	FBXO11	physical	27432908
RT35_HUMAN	MRPS35	physical	27432908
SPB1_HUMAN	FTSJ3	physical	27432908
DENR_HUMAN	DENR	physical	27432908
RL5_HUMAN	RPL5	physical	27432908
RL36_HUMAN	RPL36	physical	27432908
AP3S1_HUMAN	AP3S1	physical	27432908

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.