CLCN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLCN2_HUMAN
• UniProt AC: P51788
• Protein Name: Chloride channel protein 2
• Gene Name: CLCN2
• Organism: Homo sapiens (Human).
• Sequence Length: 898
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein.
• Protein Description: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport..
• Protein Sequence: MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAAEEG ------CCHHHHHCC	13.05	22814378
20	Phosphorylation	RALQYEQTLMYGRYT CHHHHHHHHHHCCCC	11.10	25159151
23	Phosphorylation	QYEQTLMYGRYTQDL HHHHHHHHCCCCCCH	11.10	28857561
35 (in isoform 3)	Ubiquitination	-	50.03	21906983
35 (in isoform 1)	Ubiquitination	-	50.03	21906983
35	Ubiquitination	QDLGAFAKEEAARIR CCHHHHHHHHHHHHC	50.03	22817900
76	Phosphorylation	CARCRVCSVRCHKFL CCCCCCCCCCCHHHH	15.11	22817900
134	Phosphorylation	NTSILLQYLAWVTYP CHHHHHHHHHHHCCC	9.80	30257219
146	Phosphorylation	TYPVVLITFSAGFTQ CCCCCEEEECCCHHH	13.84	30257219
148	Phosphorylation	PVVLITFSAGFTQIL CCCEEEECCCHHHHH	20.87	30257219
193	Phosphorylation	IAKVIGLTCALGSGM HHHHHHHHHHHCCCC	7.19	-
308	Phosphorylation	TITALFKTRFRLDFP HHHHHEEEEEECCCC	27.92	-
555	Phosphorylation	LQPSLYDSIIRIKKL CCHHHHHHHHHHHCC	13.32	24719451
564	Phosphorylation	IRIKKLPYLPELGWG HHHHCCCCCCCCCCC	45.37	30576142
607	Phosphorylation	LRLALHRTKGRMLAL HHHHHHHCCCCEEEE	27.40	24719451
617	Phosphorylation	RMLALVESPESMILL CEEEEEECCCCEEEE	26.87	-
641	Phosphorylation	ALLGAQLSPARRRQH HHHCCCCCHHHHHHH	12.39	29214152
693	Acetylation	AARGETHKPLKPALK CCCCCCCCCCCHHHH	60.51	18603625
696	Acetylation	GETHKPLKPALKRGP CCCCCCCCHHHHCCC	36.45	18603633
704	Phosphorylation	PALKRGPSVTRNLGE HHHHCCCCCCCCCCC	38.66	28985074
706	Phosphorylation	LKRGPSVTRNLGESP HHCCCCCCCCCCCCC	20.41	27794612
712	Phosphorylation	VTRNLGESPTGSAES CCCCCCCCCCCCHHH	26.43	29255136
714	Phosphorylation	RNLGESPTGSAESAG CCCCCCCCCCHHHHC	53.71	29255136
716	Phosphorylation	LGESPTGSAESAGIA CCCCCCCCHHHHCHH	31.20	29255136
719	Phosphorylation	SPTGSAESAGIALRS CCCCCHHHHCHHHHH	31.35	25159151
726	Phosphorylation	SAGIALRSLFCGSPP HHCHHHHHHHCCCCC	27.01	21712546
731	Phosphorylation	LRSLFCGSPPPEAAS HHHHHCCCCCHHHHH	35.10	21815630
738	Phosphorylation	SPPPEAASEKLESCE CCCHHHHHHHHHHHH	42.17	21712546
743	Phosphorylation	AASEKLESCEKRKLK HHHHHHHHHHHHCCC	37.70	21712546
758	Phosphorylation	RVRISLASDADLEGE CEEEECCCCCCCCCC	38.33	-
801	Phosphorylation	PFQLVERTSLHKTHT CCEEEECCCCCCCHH	23.33	22210691
802	Phosphorylation	FQLVERTSLHKTHTI CEEEECCCCCCCHHH	34.40	22210691
831	Phosphorylation	GRLIGIVTLKELRKA HHHHEEEEHHHHHHH	30.14	22210691
856	Phosphorylation	KVRPPLASFRDSATS EECCCCHHCCCCCCC	28.62	24719451
860	Phosphorylation	PLASFRDSATSSSDT CCHHCCCCCCCCCCC	29.23	30576142
863	Phosphorylation	SFRDSATSSSDTETT HCCCCCCCCCCCCCE	27.79	30576142
865	Phosphorylation	RDSATSSSDTETTEV CCCCCCCCCCCCEEE	48.60	28985074
869	Phosphorylation	TSSSDTETTEVHALW CCCCCCCCEEEEECC	30.28	30576142
889	Phosphorylation	HGLPREGSPSDSDDK CCCCCCCCCCCCCCC	19.24	28102081
891	Phosphorylation	LPREGSPSDSDDKCQ CCCCCCCCCCCCCCC	51.98	28102081
893	Phosphorylation	REGSPSDSDDKCQ-- CCCCCCCCCCCCC--	52.63	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLCN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLCN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLCN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF4G1_HUMAN	EIF4G1	physical	26496610
NVL_HUMAN	NVL	physical	26496610
PEX10_HUMAN	PEX10	physical	26496610
SRP14_HUMAN	SRP14	physical	26496610
SRSF8_HUMAN	SRSF8	physical	26496610
RFIP2_HUMAN	RAB11FIP2	physical	26496610
KLDC2_HUMAN	KLHDC2	physical	26496610
GPKOW_HUMAN	GPKOW	physical	26496610
ZCH10_HUMAN	ZCCHC10	physical	26496610
CCD94_HUMAN	CCDC94	physical	26496610
MUC13_HUMAN	MUC13	physical	26496610
SNIP1_HUMAN	SNIP1	physical	26496610
ZN668_HUMAN	ZNF668	physical	26496610
F192A_HUMAN	FAM192A	physical	26496610
TOE1_HUMAN	TOE1	physical	26496610
TDIF1_HUMAN	DNTTIP1	physical	26496610
CA052_HUMAN	C1orf52	physical	26496610

Drug and Disease Associations

• Kegg Disease
• H00808: Idiopathic generalized epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile abse
• OMIM Disease
• 607628: Epilepsy, idiopathic generalized 11 (EIG11)
• 607628: Juvenile absence epilepsy 2 (JAE2)
• 607628: Juvenile myoclonic epilepsy 8 (EJM8)
• 615651: Leukoencephalopathy with ataxia (LKPAT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01046: Lubiprostone