| UniProt ID | RASF7_HUMAN | |
|---|---|---|
| UniProt AC | Q02833 | |
| Protein Name | Ras association domain-containing protein 7 | |
| Gene Name | RASSF7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 373 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with gamma-tubulin. | |
| Protein Description | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.. | |
| Protein Sequence | MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 96 | Phosphorylation | PSLAGRPSSDSCPPP CCCCCCCCCCCCCCC | 45.47 | 28348404 | |
| 97 | Phosphorylation | SLAGRPSSDSCPPPE CCCCCCCCCCCCCCH | 35.90 | 25394399 | |
| 99 | Phosphorylation | AGRPSSDSCPPPERC CCCCCCCCCCCCHHE | 30.39 | 28348404 | |
| 111 | Phosphorylation | ERCLIRASLPVKPRA HHEEEEECCCCCCCC | 24.29 | 30266825 | |
| 115 | Ubiquitination | IRASLPVKPRAALGC EEECCCCCCCCCCCC | 27.18 | - | |
| 127 | Phosphorylation | LGCEPRKTLTPEPAP CCCCCCCCCCCCCCC | 36.82 | 24719451 | |
| 129 | Phosphorylation | CEPRKTLTPEPAPSL CCCCCCCCCCCCCCC | 30.73 | 21712546 | |
| 146 | Phosphorylation | PGPAAPVTPTPGCCT CCCCCCCCCCCCCCC | 22.01 | 29496963 | |
| 232 | Phosphorylation | AEAPGPPSPMASATE HCCCCCCCCCCHHHH | 30.37 | 24719451 | |
| 238 | Phosphorylation | PSPMASATERLHQDL CCCCCHHHHHHHHHH | 21.10 | 24275569 | |
| 333 (in isoform 2) | Phosphorylation | - | 51.72 | 28348404 | |
| 335 | Phosphorylation | LLGAPSESHAGAQPR HCCCCCCCCCCCCCC | 23.99 | 24719451 | |
| 335 (in isoform 2) | Phosphorylation | - | 23.99 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RASF7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RASF7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RASF7_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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