GGCT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGCT_HUMAN
• UniProt AC: O75223
• Protein Name: Gamma-glutamylcyclotransferase
• Gene Name: GGCT
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Protein Description: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis..
• Protein Sequence: MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	VTGPDEESFLYFAYG CCCCCHHHHHHEEEC	20.64	27251275
24	Phosphorylation	FLYFAYGSNLLTERI HHHEEECCCCCEEEE	16.19	22673903
37	Phosphorylation	RIHLRNPSAAFFCVA EEECCCCCHHHHHEE	35.46	20873877
42	Glutathionylation	NPSAAFFCVARLQDF CCCHHHHHEEECCEE	1.57	22555962
50	Acetylation	VARLQDFKLDFGNSQ EEECCEEEEECCCCC	56.27	27452117
56	Phosphorylation	FKLDFGNSQGKTSQT EEEECCCCCCCCCCE	40.46	27794612
89	Phosphorylation	VVWKMNKSNLNSLDE EEEEECHHHCCCCCC	41.36	28348404
93	Phosphorylation	MNKSNLNSLDEQEGV ECHHHCCCCCCCCCC	40.12	25849741
118	Acetylation	KVATQEGKEITCRSY EEEECCCCEEEEEEE	45.23	26051181
118	Ubiquitination	KVATQEGKEITCRSY EEEECCCCEEEEEEE	45.23	-
128	Phosphorylation	TCRSYLMTNYESAPP EEEEEEECCCCCCCC	31.86	27080861
130	Phosphorylation	RSYLMTNYESAPPSP EEEEECCCCCCCCCC	11.33	27080861
132	Phosphorylation	YLMTNYESAPPSPQY EEECCCCCCCCCCCC	35.40	27080861
136	Phosphorylation	NYESAPPSPQYKKII CCCCCCCCCCCCEEE	24.47	25159151
139	Phosphorylation	SAPPSPQYKKIICMG CCCCCCCCCEEEEEC	20.03	23917254
140	Ubiquitination	APPSPQYKKIICMGA CCCCCCCCEEEEECC	32.04	21890473
140	Acetylation	APPSPQYKKIICMGA CCCCCCCCEEEEECC	32.04	26051181
140 (in isoform 1)	Ubiquitination	-	32.04	21890473
141	Ubiquitination	PPSPQYKKIICMGAK CCCCCCCEEEEECCH	32.16	-
148	Acetylation	KIICMGAKENGLPLE EEEEECCHHHCCCHH	46.08	26051181
159	Ubiquitination	LPLEYQEKLKAIEPN CCHHHHHHHHCCCCC	39.50	-
161	Ubiquitination	LEYQEKLKAIEPNDY HHHHHHHHCCCCCCC	59.39	-
168	Phosphorylation	KAIEPNDYTGKVSEE HCCCCCCCCCCCHHH	24.83	22673903
169	Phosphorylation	AIEPNDYTGKVSEEI CCCCCCCCCCCHHHH	33.13	22673903
173	Phosphorylation	NDYTGKVSEEIEDII CCCCCCCHHHHHHHH	32.76	26657352
181	2-Hydroxyisobutyrylation	EEIEDIIKKGETQTL HHHHHHHHHCCCCCC	55.87	-
187	Phosphorylation	IKKGETQTL------ HHHCCCCCC------	41.68	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGCT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGCT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGCT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ITPA_HUMAN	ITPA	physical	26344197
SCLY_HUMAN	SCLY	physical	26344197
WDR1_HUMAN	WDR1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.