MIIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIIP_HUMAN
• UniProt AC: Q5JXC2
• Protein Name: Migration and invasion-inhibitory protein
• Gene Name: MIIP
• Organism: Homo sapiens (Human).
• Sequence Length: 388
• Protein Description: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion..
• Protein Sequence: MVEAEELAQLRLLNLELLRQLWVGQDAVRRSVARAASESSLESSSSYNSETPSTPETSSTSLSTSCPRGRSSVWGPPDACRGDLRDVARSGVASLPPAKCQHQESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRSILAQQSKLSKPRVTFSEESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHPEPQLPGLRESSGSGVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLAQPAHVRVSIPLSILEPPHRYHIHRRKSFDASDTLALPRHCLLGWDIFPPKSEKSSAPRNLDLWSSVSAEAQHQKLSGTSSPFHPASPMQMLPPTPTWSVPQVPRPHVPRQKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	RSVARAASESSLESS HHHHHHHHHHHHCCC	36.71	26434776
39	Phosphorylation	VARAASESSLESSSS HHHHHHHHHHCCCCC	37.41	26434776
40	Phosphorylation	ARAASESSLESSSSY HHHHHHHHHCCCCCC	31.91	26434776
43	Phosphorylation	ASESSLESSSSYNSE HHHHHHCCCCCCCCC	40.59	26434776
44	Phosphorylation	SESSLESSSSYNSET HHHHHCCCCCCCCCC	17.58	27251275
45	Phosphorylation	ESSLESSSSYNSETP HHHHCCCCCCCCCCC	46.23	27251275
46	Phosphorylation	SSLESSSSYNSETPS HHHCCCCCCCCCCCC	30.22	27251275
49	Phosphorylation	ESSSSYNSETPSTPE CCCCCCCCCCCCCCC	34.31	27251275
51	Phosphorylation	SSSYNSETPSTPETS CCCCCCCCCCCCCCC	23.51	27251275
54	Phosphorylation	YNSETPSTPETSSTS CCCCCCCCCCCCCCC	26.75	-
57	Phosphorylation	ETPSTPETSSTSLST CCCCCCCCCCCCCCC	29.22	-
61	Phosphorylation	TPETSSTSLSTSCPR CCCCCCCCCCCCCCC	23.44	-
63	Phosphorylation	ETSSTSLSTSCPRGR CCCCCCCCCCCCCCC	20.31	-
99	Ubiquitination	VASLPPAKCQHQESL CCCCCHHHCCCHHHC	39.95	-
113	Phosphorylation	LGRPRPHSAPSLGTS CCCCCCCCCCCCCCC	44.55	29255136
116	Phosphorylation	PRPHSAPSLGTSSLR CCCCCCCCCCCCCCC	38.86	29255136
141	Phosphorylation	PGPQEAQTPRSILAQ CCCCHHCCHHHHHHH	27.93	21815630
151	Ubiquitination	SILAQQSKLSKPRVT HHHHHHHCCCCCCCC	53.06	-
154	Ubiquitination	AQQSKLSKPRVTFSE HHHHCCCCCCCCCCC	47.48	-
200	Phosphorylation	SQPEAFFSKLQEFRE CCHHHHHHHHHHHHH	26.46	21815630
210	Ubiquitination	QEFRETNKEECICSH HHHHHHCHHHCCCCC	63.41	-
216	Phosphorylation	NKEECICSHPEPQLP CHHHCCCCCCCCCCC	23.36	28842319
241	Phosphorylation	EEDHECVYCYRVNRR CCCCCEEEEEEECCE	8.74	-
258	Phosphorylation	PVPVDPGTPCRLCRT CCCCCCCCCCCCCCC	25.30	25850435
303	Phosphorylation	YHIHRRKSFDASDTL EEECCCCCCCCCCCC	26.92	29255136
307	Phosphorylation	RRKSFDASDTLALPR CCCCCCCCCCCCCCC	32.73	30266825
309	Phosphorylation	KSFDASDTLALPRHC CCCCCCCCCCCCCHH	16.07	23403867
326	Ubiquitination	GWDIFPPKSEKSSAP CCCCCCCCCCCCCCC	72.05	-
329	Ubiquitination	IFPPKSEKSSAPRNL CCCCCCCCCCCCCCC	57.72	-
352	Phosphorylation	EAQHQKLSGTSSPFH HHHHHHHCCCCCCCC	47.24	24719451
354	Phosphorylation	QHQKLSGTSSPFHPA HHHHHCCCCCCCCCC	23.74	-
362	Phosphorylation	SSPFHPASPMQMLPP CCCCCCCCCCCCCCC	25.92	-
370	Phosphorylation	PMQMLPPTPTWSVPQ CCCCCCCCCCCCCCC	31.26	-
372	Phosphorylation	QMLPPTPTWSVPQVP CCCCCCCCCCCCCCC	32.61	-
374	Phosphorylation	LPPTPTWSVPQVPRP CCCCCCCCCCCCCCC	26.80	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
303	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC6_HUMAN	HDAC6	physical	20008322

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.