GYS2_HUMAN - dbPTM
GYS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GYS2_HUMAN
UniProt AC P54840
Protein Name Glycogen [starch] synthase, liver
Gene Name GYS2
Organism Homo sapiens (Human).
Sequence Length 703
Subcellular Localization
Protein Description Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan..
Protein Sequence MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MLRGRSLSVTSLG
--CCCCCCCEEECCC		28.02-
8PhosphorylationMLRGRSLSVTSLGGL
CCCCCCCEEECCCCC		25.2924275569
10PhosphorylationRGRSLSVTSLGGLPQ
CCCCCEEECCCCCCC		18.1724275569
11PhosphorylationGRSLSVTSLGGLPQW
CCCCEEECCCCCCCC		23.9024275569
45PhosphorylationTNKVGGIYTVIQTKA
HHHCCCEEEEEEECC		9.7620090780
46PhosphorylationNKVGGIYTVIQTKAK
HHCCCEEEEEEECCC		14.8220068231
50PhosphorylationGIYTVIQTKAKTTAD
CEEEEEEECCCCCHH		23.1120068231
203PhosphorylationLPIATIFTTHATLLG
CCCEEEECCHHHHHH		17.52-
304UbiquitinationHAMYKARIQDFVRGH
HHHHHHHHHHHHHHH		5.7223000965
310UbiquitinationRIQDFVRGHFYGHLD
HHHHHHHHHCCCCCC		15.2323000965
371AcetylationVFFIMPAKTNNFNVE
EEEEEECCCCCCCHH		46.0110563019
379PhosphorylationTNNFNVETLKGQAVR
CCCCCHHHHCCHHHH		29.5028857561
381UbiquitinationNFNVETLKGQAVRKQ
CCCHHHHCCHHHHHH		57.2923000965
387AcetylationLKGQAVRKQLWDVAH
HCCHHHHHHHHHHHH		43.0520167786
387UbiquitinationLKGQAVRKQLWDVAH
HCCHHHHHHHHHHHH		43.0523000965
397AcetylationWDVAHSVKEKFGKKL
HHHHHHHHHHHHHHH		59.1920167786
405PhosphorylationEKFGKKLYDALLRGE
HHHHHHHHHHHHCCC		14.19-
426PhosphorylationILDRDDLTIMKRAIF
CCCHHHCHHHHHHHH		26.48-
459PhosphorylationSTDPILSTIRRIGLF
CCCHHHHHHHHHCCC		18.3020363803
612PhosphorylationYQHARHLTLSRAFPD
HHHHHHHHHCCCCCC		19.3024719451
626PhosphorylationDKFHVELTSPPTTEG
CCEEEEECCCCCCCC		26.1925072903
627PhosphorylationKFHVELTSPPTTEGF
CEEEEECCCCCCCCC		41.3225072903
630PhosphorylationVELTSPPTTEGFKYP
EEECCCCCCCCCCCC		40.6425072903
631PhosphorylationELTSPPTTEGFKYPR
EECCCCCCCCCCCCC		39.6325072903
641PhosphorylationFKYPRPSSVPPSPSG
CCCCCCCCCCCCCCC		41.13-
645PhosphorylationRPSSVPPSPSGSQAS
CCCCCCCCCCCCCCC		26.15-
649PhosphorylationVPPSPSGSQASSPQS
CCCCCCCCCCCCCCC		27.23-
653PhosphorylationPSGSQASSPQSSDVE
CCCCCCCCCCCCCCC		29.94-
657PhosphorylationQASSPQSSDVEDEVE
CCCCCCCCCCCHHHH		40.19-
683PhosphorylationRDRLNIKSPFSLSHV
HHHCCCCCCCCHHCC		27.648203908
686PhosphorylationLNIKSPFSLSHVPHG
CCCCCCCCHHCCCCC		32.1425072903
688PhosphorylationIKSPFSLSHVPHGKK
CCCCCCHHCCCCCCC		22.6525072903
694AcetylationLSHVPHGKKKLHGEY
HHCCCCCCCCCCCCC		43.64-
695AcetylationSHVPHGKKKLHGEYK
HCCCCCCCCCCCCCC		66.22-
696AcetylationHVPHGKKKLHGEYKN
CCCCCCCCCCCCCCC		49.56-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
8SPhosphorylationKinasePKA-Uniprot
641SPhosphorylationKinaseGSK3-ALPHAP49840
Uniprot
641SPhosphorylationKinaseGSK3-BETAP49841
Uniprot
645SPhosphorylationKinaseGSK3-ALPHAP49840
Uniprot
645SPhosphorylationKinaseGSK3-BETAP49841
Uniprot
649SPhosphorylationKinaseGSK3-ALPHAP49840
Uniprot
649SPhosphorylationKinaseGSK3-BETAP49841
Uniprot
653SPhosphorylationKinaseGSK3-ALPHAP49840
Uniprot
653SPhosphorylationKinaseGSK3-BETAP49841
Uniprot
657SPhosphorylationKinaseCK2-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
8SPhosphorylation

-
8SPhosphorylation

-
641SPhosphorylation

-
641SPhosphorylation

-
641SPhosphorylation

-
645SPhosphorylation

-
645SPhosphorylation

-
649SPhosphorylation

-
653SPhosphorylation

-
657SPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GYS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TNR1A_HUMANTNFRSF1Aphysical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
240600Glycogen storage disease 0 (GSD0)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GYS2_HUMAN

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Related Literatures of Post-Translational Modification

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