BTBDA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTBDA_MOUSE
• UniProt AC: Q80X66
• Protein Name: BTB/POZ domain-containing protein 10
• Gene Name: Btbd10
• Organism: Mus musculus (Mouse).
• Sequence Length: 475
• Subcellular Localization: Nucleus . Cytoplasm . Colocalizes with KCTD20 in filamentous structures.
• Protein Description: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells..
• Protein Sequence: MAGRPHPYDSNSSDPENWDRKLHSRPRKLYKHSSSASRVAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERAESQLTPCIRNVTSPTRQHHIEREKDHSSSRPSSPRPQRASPNGSMSSAGNSSRNSSQSSSDGSCKTSGEMVFVYENAKEGARNVRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPSHPASGNNDLDPDAQNPML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	HPYDSNSSDPENWDR CCCCCCCCCCCHHHH	62.53	25338131
50	Phosphorylation	GVDHTKMSLHGASGG CCCCCCCCCCCCCCC	20.83	28066266
67	Phosphorylation	RSRDRRRSSDRSRDS HHHHHHHCCCCCCCC	34.48	-
71	Phosphorylation	RRRSSDRSRDSSHER HHHCCCCCCCCHHHH	45.49	-
74	Phosphorylation	SSDRSRDSSHERAES CCCCCCCCHHHHHHH	32.27	26643407
75	Phosphorylation	SDRSRDSSHERAESQ CCCCCCCHHHHHHHH	33.39	25266776
81	Phosphorylation	SSHERAESQLTPCIR CHHHHHHHHHHHHHH	29.52	29899451
91	Phosphorylation	TPCIRNVTSPTRQHH HHHHHHCCCCCHHHH	32.32	25266776
92	Phosphorylation	PCIRNVTSPTRQHHI HHHHHCCCCCHHHHH	21.71	22324799
94	Phosphorylation	IRNVTSPTRQHHIER HHHCCCCCHHHHHHH	42.61	22324799
106	Phosphorylation	IEREKDHSSSRPSSP HHHHCCCCCCCCCCC	39.89	29472430
107	Phosphorylation	EREKDHSSSRPSSPR HHHCCCCCCCCCCCC	27.26	29472430
108	Phosphorylation	REKDHSSSRPSSPRP HHCCCCCCCCCCCCC	51.75	29472430
111	Phosphorylation	DHSSSRPSSPRPQRA CCCCCCCCCCCCCCC	52.44	29472430
112	Phosphorylation	HSSSRPSSPRPQRAS CCCCCCCCCCCCCCC	27.84	25266776
119	Phosphorylation	SPRPQRASPNGSMSS CCCCCCCCCCCCCCC	22.53	25521595
123	Phosphorylation	QRASPNGSMSSAGNS CCCCCCCCCCCCCCC	23.33	24719451
222	Phosphorylation	EVAEGIGSTVFRAIL EEECCCCHHHHHHHH	21.34	-
357	Phosphorylation	ENRDVAKSVLKERGL HCHHHHHHHHHHCCC	23.97	24453211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BTBDA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTBDA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTBDA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BTBDA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.