PPR3C_HUMAN - dbPTM
PPR3C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPR3C_HUMAN
UniProt AC Q9UQK1
Protein Name Protein phosphatase 1 regulatory subunit 3C
Gene Name PPP1R3C {ECO:0000312|HGNC:HGNC:9293}
Organism Homo sapiens (Human).
Sequence Length 317
Subcellular Localization
Protein Description Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types..
Protein Sequence MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSCTRMIQV
------CCCEEEEEE
24.9722210691
4Phosphorylation----MSCTRMIQVLD
----CCCEEEEEECC
18.9022210691
33PhosphorylationMRLCLAHSPPVKSFL
HHHHHHCCCCHHHHC
25.8722817900
65UbiquitinationLKSCLNIKHKAKSQN
HHHHHCCCHHHHCCC
37.6729967540
69AcetylationLNIKHKAKSQNDWKC
HCCCHHHHCCCCCCC
58.3319825879
69UbiquitinationLNIKHKAKSQNDWKC
HCCCHHHHCCCCCCC
58.3329967540
75UbiquitinationAKSQNDWKCSHNQAK
HHCCCCCCCCHHHHC
28.8229967540
82AcetylationKCSHNQAKKRVVFAD
CCCHHHHCCEEEEEC
31.2019825887
132UbiquitinationALKHHEEKNLILDFP
HHHHHHHCCEEEECC
54.8129967540
150PhosphorylationTDYLSFRSHFQKNFV
CCHHHHHHHCHHCEE
27.0029391485
163PhosphorylationFVCLENCSLQERTVT
EEEEECCCCCEEEEE
44.6723898821
168PhosphorylationNCSLQERTVTGTVKV
CCCCCEEEEEEEEEE
22.9723898821
170PhosphorylationSLQERTVTGTVKVKN
CCCEEEEEEEEEEEE
26.9023898821
172PhosphorylationQERTVTGTVKVKNVS
CEEEEEEEEEEEEEC
14.0523898821
174UbiquitinationRTVTGTVKVKNVSFE
EEEEEEEEEEEECCC
47.5329967540
176UbiquitinationVTGTVKVKNVSFEKK
EEEEEEEEEECCCEE
46.0129967540
268PhosphorylationWKPDGVQTQMAPQDC
ECCCCCCCCCCCCCC
20.2222210691
283UbiquitinationAFHQTSPKTELESTI
CCCCCCCCCHHEEEC
55.1621963094
288PhosphorylationSPKTELESTIFGSPR
CCCCHHEEECCCCHH
39.1522210691
289PhosphorylationPKTELESTIFGSPRL
CCCHHEEECCCCHHH
15.7925850435
293PhosphorylationLESTIFGSPRLASGL
HEEECCCCHHHHCCC
8.9725850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
33SPhosphorylationKinasePRKAA1Q13131
GPS
293SPhosphorylationKinasePRKAA1Q13131
GPS
-KUbiquitinationE3 ubiquitin ligaseNHLRC1Q6VVB1
PMID:18029386

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPR3C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPR3C_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EPM2A_HUMANEPM2Aphysical
18070875
NHLC1_HUMANNHLRC1physical
18029386
SGTA_HUMANSGTAphysical
21900206
A4_HUMANAPPphysical
21832049
GYS2_HUMANGYS2physical
26186194
GYS1_HUMANGYS1physical
26186194
STBD1_HUMANSTBD1physical
26186194
TRXR2_HUMANTXNRD2physical
26186194
LACRT_HUMANLACRTphysical
26186194
GLYG_HUMANGYG1physical
26186194
EEA1_HUMANEEA1physical
26186194
PPR3D_HUMANPPP1R3Dphysical
26186194
GBG5_HUMANGNG5physical
26186194
STBD1_HUMANSTBD1physical
28514442
PPR3D_HUMANPPP1R3Dphysical
28514442
GYS1_HUMANGYS1physical
28514442
LACRT_HUMANLACRTphysical
28514442
ADPPT_HUMANAASDHPPTphysical
28514442
GYS2_HUMANGYS2physical
28514442
GLYG_HUMANGYG1physical
28514442
TRXR2_HUMANTXNRD2physical
28514442
GBG5_HUMANGNG5physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPR3C_HUMAN

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Related Literatures of Post-Translational Modification

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