UniProt ID | PPR3C_HUMAN | |
---|---|---|
UniProt AC | Q9UQK1 | |
Protein Name | Protein phosphatase 1 regulatory subunit 3C | |
Gene Name | PPP1R3C {ECO:0000312|HGNC:HGNC:9293} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 317 | |
Subcellular Localization | ||
Protein Description | Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.. | |
Protein Sequence | MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MSCTRMIQV ------CCCEEEEEE | 24.97 | 22210691 | |
4 | Phosphorylation | ----MSCTRMIQVLD ----CCCEEEEEECC | 18.90 | 22210691 | |
33 | Phosphorylation | MRLCLAHSPPVKSFL HHHHHHCCCCHHHHC | 25.87 | 22817900 | |
65 | Ubiquitination | LKSCLNIKHKAKSQN HHHHHCCCHHHHCCC | 37.67 | 29967540 | |
69 | Acetylation | LNIKHKAKSQNDWKC HCCCHHHHCCCCCCC | 58.33 | 19825879 | |
69 | Ubiquitination | LNIKHKAKSQNDWKC HCCCHHHHCCCCCCC | 58.33 | 29967540 | |
75 | Ubiquitination | AKSQNDWKCSHNQAK HHCCCCCCCCHHHHC | 28.82 | 29967540 | |
82 | Acetylation | KCSHNQAKKRVVFAD CCCHHHHCCEEEEEC | 31.20 | 19825887 | |
132 | Ubiquitination | ALKHHEEKNLILDFP HHHHHHHCCEEEECC | 54.81 | 29967540 | |
150 | Phosphorylation | TDYLSFRSHFQKNFV CCHHHHHHHCHHCEE | 27.00 | 29391485 | |
163 | Phosphorylation | FVCLENCSLQERTVT EEEEECCCCCEEEEE | 44.67 | 23898821 | |
168 | Phosphorylation | NCSLQERTVTGTVKV CCCCCEEEEEEEEEE | 22.97 | 23898821 | |
170 | Phosphorylation | SLQERTVTGTVKVKN CCCEEEEEEEEEEEE | 26.90 | 23898821 | |
172 | Phosphorylation | QERTVTGTVKVKNVS CEEEEEEEEEEEEEC | 14.05 | 23898821 | |
174 | Ubiquitination | RTVTGTVKVKNVSFE EEEEEEEEEEEECCC | 47.53 | 29967540 | |
176 | Ubiquitination | VTGTVKVKNVSFEKK EEEEEEEEEECCCEE | 46.01 | 29967540 | |
268 | Phosphorylation | WKPDGVQTQMAPQDC ECCCCCCCCCCCCCC | 20.22 | 22210691 | |
283 | Ubiquitination | AFHQTSPKTELESTI CCCCCCCCCHHEEEC | 55.16 | 21963094 | |
288 | Phosphorylation | SPKTELESTIFGSPR CCCCHHEEECCCCHH | 39.15 | 22210691 | |
289 | Phosphorylation | PKTELESTIFGSPRL CCCHHEEECCCCHHH | 15.79 | 25850435 | |
293 | Phosphorylation | LESTIFGSPRLASGL HEEECCCCHHHHCCC | 8.97 | 25850435 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPR3C_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPR3C_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
EPM2A_HUMAN | EPM2A | physical | 18070875 | |
NHLC1_HUMAN | NHLRC1 | physical | 18029386 | |
SGTA_HUMAN | SGTA | physical | 21900206 | |
A4_HUMAN | APP | physical | 21832049 | |
GYS2_HUMAN | GYS2 | physical | 26186194 | |
GYS1_HUMAN | GYS1 | physical | 26186194 | |
STBD1_HUMAN | STBD1 | physical | 26186194 | |
TRXR2_HUMAN | TXNRD2 | physical | 26186194 | |
LACRT_HUMAN | LACRT | physical | 26186194 | |
GLYG_HUMAN | GYG1 | physical | 26186194 | |
EEA1_HUMAN | EEA1 | physical | 26186194 | |
PPR3D_HUMAN | PPP1R3D | physical | 26186194 | |
GBG5_HUMAN | GNG5 | physical | 26186194 | |
STBD1_HUMAN | STBD1 | physical | 28514442 | |
PPR3D_HUMAN | PPP1R3D | physical | 28514442 | |
GYS1_HUMAN | GYS1 | physical | 28514442 | |
LACRT_HUMAN | LACRT | physical | 28514442 | |
ADPPT_HUMAN | AASDHPPT | physical | 28514442 | |
GYS2_HUMAN | GYS2 | physical | 28514442 | |
GLYG_HUMAN | GYG1 | physical | 28514442 | |
TRXR2_HUMAN | TXNRD2 | physical | 28514442 | |
GBG5_HUMAN | GNG5 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...