PPR3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPR3C_HUMAN
• UniProt AC: Q9UQK1
• Protein Name: Protein phosphatase 1 regulatory subunit 3C
• Gene Name: PPP1R3C {ECO:0000312|HGNC:HGNC:9293}
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Protein Description: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types..
• Protein Sequence: MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSCTRMIQV ------CCCEEEEEE	24.97	22210691
4	Phosphorylation	----MSCTRMIQVLD ----CCCEEEEEECC	18.90	22210691
33	Phosphorylation	MRLCLAHSPPVKSFL HHHHHHCCCCHHHHC	25.87	22817900
65	Ubiquitination	LKSCLNIKHKAKSQN HHHHHCCCHHHHCCC	37.67	29967540
69	Acetylation	LNIKHKAKSQNDWKC HCCCHHHHCCCCCCC	58.33	19825879
69	Ubiquitination	LNIKHKAKSQNDWKC HCCCHHHHCCCCCCC	58.33	29967540
75	Ubiquitination	AKSQNDWKCSHNQAK HHCCCCCCCCHHHHC	28.82	29967540
82	Acetylation	KCSHNQAKKRVVFAD CCCHHHHCCEEEEEC	31.20	19825887
132	Ubiquitination	ALKHHEEKNLILDFP HHHHHHHCCEEEECC	54.81	29967540
150	Phosphorylation	TDYLSFRSHFQKNFV CCHHHHHHHCHHCEE	27.00	29391485
163	Phosphorylation	FVCLENCSLQERTVT EEEEECCCCCEEEEE	44.67	23898821
168	Phosphorylation	NCSLQERTVTGTVKV CCCCCEEEEEEEEEE	22.97	23898821
170	Phosphorylation	SLQERTVTGTVKVKN CCCEEEEEEEEEEEE	26.90	23898821
172	Phosphorylation	QERTVTGTVKVKNVS CEEEEEEEEEEEEEC	14.05	23898821
174	Ubiquitination	RTVTGTVKVKNVSFE EEEEEEEEEEEECCC	47.53	29967540
176	Ubiquitination	VTGTVKVKNVSFEKK EEEEEEEEEECCCEE	46.01	29967540
268	Phosphorylation	WKPDGVQTQMAPQDC ECCCCCCCCCCCCCC	20.22	22210691
283	Ubiquitination	AFHQTSPKTELESTI CCCCCCCCCHHEEEC	55.16	21963094
288	Phosphorylation	SPKTELESTIFGSPR CCCCHHEEECCCCHH	39.15	22210691
289	Phosphorylation	PKTELESTIFGSPRL CCCHHEEECCCCHHH	15.79	25850435
293	Phosphorylation	LESTIFGSPRLASGL HEEECCCCHHHHCCC	8.97	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
33	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
293	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	NHLRC1	Q6VVB1	PMID:18029386

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPR3C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPR3C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPM2A_HUMAN	EPM2A	physical	18070875
NHLC1_HUMAN	NHLRC1	physical	18029386
SGTA_HUMAN	SGTA	physical	21900206
A4_HUMAN	APP	physical	21832049
GYS2_HUMAN	GYS2	physical	26186194
GYS1_HUMAN	GYS1	physical	26186194
STBD1_HUMAN	STBD1	physical	26186194
TRXR2_HUMAN	TXNRD2	physical	26186194
LACRT_HUMAN	LACRT	physical	26186194
GLYG_HUMAN	GYG1	physical	26186194
EEA1_HUMAN	EEA1	physical	26186194
PPR3D_HUMAN	PPP1R3D	physical	26186194
GBG5_HUMAN	GNG5	physical	26186194
STBD1_HUMAN	STBD1	physical	28514442
PPR3D_HUMAN	PPP1R3D	physical	28514442
GYS1_HUMAN	GYS1	physical	28514442
LACRT_HUMAN	LACRT	physical	28514442
ADPPT_HUMAN	AASDHPPT	physical	28514442
GYS2_HUMAN	GYS2	physical	28514442
GLYG_HUMAN	GYG1	physical	28514442
TRXR2_HUMAN	TXNRD2	physical	28514442
GBG5_HUMAN	GNG5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.