PPR3D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPR3D_HUMAN
• UniProt AC: O95685
• Protein Name: Protein phosphatase 1 regulatory subunit 3D
• Gene Name: PPP1R3D
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Protein Description: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis..
• Protein Sequence: MSRGPSSAVLPSALGSRKLGPRSLSCLSDLDGGVALEPRACRPPGSPGRAPPPTPAPSGCDPRLRPIILRRARSLPSSPERRQKAAGAPGAACRPGCSQKLRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLHCLVPDFPPPVEAADFGERLQRQLVCLERVTCSDLGISGTVRVCNVAFEKQVAVRYTFSGWRSTHEAVARWRGPAGPEGTEDVFTFGFPVPPFLLELGSRVHFAVRYQVAGAEYWDNNDHRDYSLTCRNHALHMPRGECEESWIHFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRGPSSAV ------CCCCCCCCC	46.04	27251275
3	Methylation	-----MSRGPSSAVL -----CCCCCCCCCC	60.80	115383969
6	Phosphorylation	--MSRGPSSAVLPSA --CCCCCCCCCCCHH	33.48	23186163
7	Phosphorylation	-MSRGPSSAVLPSAL -CCCCCCCCCCCHHH	26.06	28555341
16	Phosphorylation	VLPSALGSRKLGPRS CCCHHHCCCCCCCCC	27.39	-
23	Phosphorylation	SRKLGPRSLSCLSDL CCCCCCCCHHHCCCC	27.97	23927012
25	Phosphorylation	KLGPRSLSCLSDLDG CCCCCCHHHCCCCCC	17.79	23927012
28	Phosphorylation	PRSLSCLSDLDGGVA CCCHHHCCCCCCCEE	40.22	23927012
46	Phosphorylation	RACRPPGSPGRAPPP EECCCCCCCCCCCCC	29.92	23401153
54	Phosphorylation	PGRAPPPTPAPSGCD CCCCCCCCCCCCCCC	37.54	23927012
58	Phosphorylation	PPPTPAPSGCDPRLR CCCCCCCCCCCCCHH	54.91	23927012
74	Phosphorylation	IILRRARSLPSSPER HHHHHHHCCCCCHHH	43.58	29255136
77	Phosphorylation	RRARSLPSSPERRQK HHHHCCCCCHHHHHH	64.91	22167270
78	Phosphorylation	RARSLPSSPERRQKA HHHCCCCCHHHHHHH	28.92	22167270
98	Phosphorylation	AACRPGCSQKLRVRF CCCCCCCCHHHHHHH	35.94	28348404
100	Ubiquitination	CRPGCSQKLRVRFAD CCCCCCHHHHHHHHH	23.20	-
126	Phosphorylation	FNAGDDPSVPLHVLS ECCCCCCCCCHHHHH	43.28	28060719
133	Phosphorylation	SVPLHVLSRLAINSD CCCHHHHHHHHHCCC	24.94	25849741
144	Phosphorylation	INSDLCCSSQDLEFT HCCCCCCCCCCCEEE	30.00	27251275
145	Phosphorylation	NSDLCCSSQDLEFTL CCCCCCCCCCCEEEE	17.50	27251275
151	Phosphorylation	SSQDLEFTLHCLVPD CCCCCEEEEEEECCC	13.25	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPR3D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPR3D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPR3D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP1G_HUMAN	PPP1CC	physical	9414128
EPM2A_HUMAN	EPM2A	physical	23624058

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-25; SER-28;SER-74 AND SER-77, AND MASS SPECTROMETRY.
PubMed: 18669648

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-78, AND MASSSPECTROMETRY.
PubMed: 18088087