CSRN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSRN1_HUMAN
• UniProt AC: Q96S65
• Protein Name: Cysteine/serine-rich nuclear protein 1
• Gene Name: CSRNP1
• Organism: Homo sapiens (Human).
• Sequence Length: 589
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis..
• Protein Sequence: MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFTSGVLDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGRSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	DQLDEDNSSVSSSSS HHCCCCCCCCCCCCC	44.43	30576142
25	Phosphorylation	SVSSSSSSSGCQSRS CCCCCCCCCCCCCCC	32.47	30576142
30	Phosphorylation	SSSSGCQSRSCSPSS CCCCCCCCCCCCCCC	30.18	-
32	Phosphorylation	SSGCQSRSCSPSSSV CCCCCCCCCCCCCCC	24.97	26434776
34	Phosphorylation	GCQSRSCSPSSSVSR CCCCCCCCCCCCCCC	29.12	26434776
36	Phosphorylation	QSRSCSPSSSVSRAW CCCCCCCCCCCCCCC	20.96	26434776
37	Phosphorylation	SRSCSPSSSVSRAWD CCCCCCCCCCCCCCC	37.84	26434776
38	Phosphorylation	RSCSPSSSVSRAWDS CCCCCCCCCCCCCCC	28.57	-
45	Phosphorylation	SVSRAWDSEEEGPWD CCCCCCCCCCCCCCC	35.89	24850871
66	Phosphorylation	RDFCGPRSFTPLSIL CCCCCCCCCCHHHHH	36.28	26270265
68	Phosphorylation	FCGPRSFTPLSILKR CCCCCCCCHHHHHHH	25.27	21815630
71	Phosphorylation	PRSFTPLSILKRARR CCCCCHHHHHHHHHH	27.38	21712546
74	Ubiquitination	FTPLSILKRARRERP CCHHHHHHHHHHCCC	42.20	-
106	Methylation	GFTSVPSRGGCTLGM CCCCCCCCCCCHHHH	39.18	-
110	Phosphorylation	VPSRGGCTLGMALRH CCCCCCCHHHHHHHH	29.62	24719451
145	Ubiquitination	EKLRQRLKEEKLEML HHHHHHHHHHHHHHH	67.05	-
179	Phosphorylation	VDAIDDASVEEDLAV CCCCCCCCHHHHHHH	36.74	28348404
319	Phosphorylation	LEAPAQGSPPSPGEE HCCCCCCCCCCCCCC	22.89	26074081
322	Phosphorylation	PAQGSPPSPGEEALV CCCCCCCCCCCCCCC	49.25	26074081
543	Phosphorylation	HFPLPGLSPPGDASS CCCCCCCCCCCCHHH	34.66	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSRN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSRN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSRN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN587_HUMAN	ZNF587	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
TEANC_HUMAN	TCEANC	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.