PPR26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPR26_HUMAN
• UniProt AC: Q5T8A7
• Protein Name: Protein phosphatase 1 regulatory subunit 26
• Gene Name: PPP1R26
• Organism: Homo sapiens (Human).
• Sequence Length: 1209
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation..
• Protein Sequence: MFLMNASPVVALQSKWEAFGPPGSCRFPRCFSEADEGVESASVSARVQMLISTLQRDGAARGTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLAGFSPLLSTQLFHFGKGVSWGGRQAGLFSPHLGLPLQGPSFSAFREAQAGPSPVFGSPHLLAKKDGGPWPTRKAQAGLSLHDRRSSGSEESILDLRYRRRVNRDDQEQDALGSDASDFSDTSTEDSGGSSVVKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	SPVVALQSKWEAFGP CCEEEEHHHHHHHCC	40.35	-
52	Phosphorylation	ARVQMLISTLQRDGA HHHHHHHHHHHHCCC	21.07	27174698
53	Phosphorylation	RVQMLISTLQRDGAA HHHHHHHHHHHCCCC	21.66	27174698
140	Phosphorylation	IEEAIQEYLKAKSGA HHHHHHHHHHHHCCC	9.34	24275569
145	Phosphorylation	QEYLKAKSGAAQPGA HHHHHHHCCCCCCCC	38.23	24275569
163	Phosphorylation	QPGAAQPSRAAGGGS CCCCCCCCCCCCCCC	23.59	24275569
170	Phosphorylation	SRAAGGGSRCKPEPA CCCCCCCCCCCCCCC	37.47	25367160
200	Phosphorylation	GSGGGPGSQVGSSKD CCCCCCCCCCCCCCC	25.48	23879269
205	Phosphorylation	PGSQVGSSKDQGSAS CCCCCCCCCCCCCCC	34.03	-
248	Phosphorylation	ETQKCDGSVEKKPDT HCCCCCCCCCCCCCC	17.53	-
259	Phosphorylation	KPDTNENSAKSLLKS CCCCCHHHHHHHHHH	30.78	-
261	Ubiquitination	DTNENSAKSLLKSHQ CCCHHHHHHHHHHCC	41.27	-
262	Phosphorylation	TNENSAKSLLKSHQE CCHHHHHHHHHHCCC	38.35	24719451
265	Methylation	NSAKSLLKSHQEPPT HHHHHHHHHCCCCCC	51.70	115975587
338	Acetylation	AQNKGGIKRSASAAR HHHCCCHHHHHHHHH	43.50	20167786
407	Phosphorylation	PDPPAHSTSSATKSA CCCCCCCCCHHHHHC	19.48	30576142
409	Phosphorylation	PPAHSTSSATKSALP CCCCCCCHHHHHCCC	39.79	30576142
433	Phosphorylation	KKLVATKTMDPGPGG CCEEEEEECCCCCCC	23.58	-
453	Phosphorylation	APKLLKETKAPPPAS HHHHHHHCCCCCCCC	30.80	20363803
460	Phosphorylation	TKAPPPASPASRSEF CCCCCCCCCCCHHHH	27.11	23090842
463	Phosphorylation	PPPASPASRSEFVER CCCCCCCCHHHHHHH	39.46	20363803
605	Phosphorylation	GGGHVRPSTPKKMQE CCCCCCCCCCHHHHH	46.94	22210691
605	O-linked_Glycosylation	GGGHVRPSTPKKMQE CCCCCCCCCCHHHHH	46.94	30379171
606	Phosphorylation	GGHVRPSTPKKMQEV CCCCCCCCCHHHHHH	41.64	22210691
618	Phosphorylation	QEVVKDGSQDADHSQ HHHHCCCCCCCCCCC	34.71	-
624	Phosphorylation	GSQDADHSQGRAEPG CCCCCCCCCCCCCCC	34.57	-
679	Phosphorylation	RRLDEKESSEDKSSS HHHCHHHCCCCHHHC	50.52	28270605
680	Phosphorylation	RLDEKESSEDKSSSL HHCHHHCCCCHHHCC	51.40	28270605
684	Phosphorylation	KESSEDKSSSLDSDE HHCCCCHHHCCCCHH	37.16	28270605
685	Phosphorylation	ESSEDKSSSLDSDED HCCCCHHHCCCCHHH	40.43	28270605
686	Phosphorylation	SSEDKSSSLDSDEDL CCCCHHHCCCCHHHH	43.20	28270605
689	Phosphorylation	DKSSSLDSDEDLDTA CHHHCCCCHHHHHHH	48.47	28270605
695	Phosphorylation	DSDEDLDTAIKDLLR CCHHHHHHHHHHHHH	37.26	28270605
751	Methylation	DRGPPVLKSCLSKSK HHCCHHHHHHHCCCC	39.08	115975591
752	O-linked_Glycosylation	RGPPVLKSCLSKSKR HCCHHHHHHHCCCCC	19.01	30379171
755	O-linked_Glycosylation	PVLKSCLSKSKRDSG HHHHHHHCCCCCCCC	38.93	30379171
771	Phosphorylation	GPGKKPPSVFGSTAE CCCCCCCCCCCHHHH	38.31	23403867
775	Phosphorylation	KPPSVFGSTAERMRQ CCCCCCCHHHHHHHH	16.99	23403867
776	Phosphorylation	PPSVFGSTAERMRQE CCCCCCHHHHHHHHH	32.68	23403867
803	Phosphorylation	VRRPASASASEGNPF HCCCCCCCCCCCCCC	29.81	28555341
916	Phosphorylation	ESAGAQGTAGLFSQG CCCCCCCCCCCCCCC	12.89	22468782
921	Phosphorylation	QGTAGLFSQGGKGLP CCCCCCCCCCCCCCC	32.72	22468782
925	Acetylation	GLFSQGGKGLPAAPA CCCCCCCCCCCCCCC	65.19	26051181
952	Phosphorylation	GVSAKGLSVSRRNVY CCCCCCCCEEECEEE	27.07	24719451
1024	Phosphorylation	AGAQADRTPPWSDFA CCCCCCCCCCHHHHC	33.96	-
1038	Phosphorylation	AHQSRLPSPWVLRSE CCHHCCCCCEEECCC	35.67	-
1079	Phosphorylation	SLPLAGFSPLLSTQL CCCCCCCCCCCHHHH	17.45	25159151
1104	Phosphorylation	GRQAGLFSPHLGLPL CCCCCCCCCCCCCCC	19.22	28270605
1115	Phosphorylation	GLPLQGPSFSAFREA CCCCCCCCHHHHHHH	38.36	28270605
1117	Phosphorylation	PLQGPSFSAFREAQA CCCCCCHHHHHHHHC	30.73	28270605
1127	Phosphorylation	REAQAGPSPVFGSPH HHHHCCCCCCCCCCC	32.55	25159151
1132	Phosphorylation	GPSPVFGSPHLLAKK CCCCCCCCCCCEECC	9.55	25159151
1160	Phosphorylation	LSLHDRRSSGSEESI CCCCCCCCCCCHHHH	39.69	28450419
1161	Phosphorylation	SLHDRRSSGSEESIL CCCCCCCCCCHHHHH	44.52	25849741
1163	Phosphorylation	HDRRSSGSEESILDL CCCCCCCCHHHHHHH	39.89	28450419
1166	Phosphorylation	RSSGSEESILDLRYR CCCCCHHHHHHHHHH	25.13	23186163
1191	Phosphorylation	DALGSDASDFSDTST HHCCCCHHHHCCCCC	44.15	30576142
1194	Phosphorylation	GSDASDFSDTSTEDS CCCHHHHCCCCCCCC	44.99	30576142
1196	Phosphorylation	DASDFSDTSTEDSGG CHHHHCCCCCCCCCC	36.03	30576142
1204	Phosphorylation	STEDSGGSSVVKV-- CCCCCCCCCCEEC--	24.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPR26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPR26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPR26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB_HUMAN	RB1	physical	26442585

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.