SHOC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHOC2_HUMAN
• UniProt AC: Q9UQ13
• Protein Name: Leucine-rich repeat protein SHOC-2
• Gene Name: SHOC2
• Organism: Homo sapiens (Human).
• Sequence Length: 582
• Subcellular Localization: Cytoplasm . Nucleus . Translocates from cytoplasm to nucleus upon growth factor stimulation.
• Protein Description: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes..
• Protein Sequence: MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAAQPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSLGKEK ------CCCCCCCCC	28.74	21406692
3	Phosphorylation	-----MSSSLGKEKD -----CCCCCCCCCC	28.43	21406692
4	Phosphorylation	----MSSSLGKEKDS ----CCCCCCCCCCC	33.56	21406692
11	Phosphorylation	SLGKEKDSKEKDPKV CCCCCCCCCCCCCCC	54.50	21406692
14	Ubiquitination	KEKDSKEKDPKVPSA CCCCCCCCCCCCCCH	80.98	24816145
57	Phosphorylation	AKDGKKDSSAAQPGV CCCCCCCCCCCCCCE	30.65	28555341
58	Phosphorylation	KDGKKDSSAAQPGVA CCCCCCCCCCCCCEE	37.44	28555341
71	Phosphorylation	VAFSVDNTIKRPNPA EEEEECCCCCCCCCC	24.34	30576142
81	Phosphorylation	RPNPAPGTRKKSSNA CCCCCCCCCCCCCCH	37.95	28857561
85	Phosphorylation	APGTRKKSSNAEVIK CCCCCCCCCCHHHHH	31.68	23403867
86	Phosphorylation	PGTRKKSSNAEVIKE CCCCCCCCCHHHHHH	49.27	29214152
92	Ubiquitination	SSNAEVIKELNKCRE CCCHHHHHHHHHHHH	62.41	24816145
102	Phosphorylation	NKCREENSMRLDLSK HHHHHHHCCCCCCHH	14.46	24719451
111	Phosphorylation	RLDLSKRSIHILPSS CCCCHHHHEECCCHH	23.43	20068231
117	Phosphorylation	RSIHILPSSIKELTQ HHEECCCHHHHHHHH	41.05	20068231
118	Phosphorylation	SIHILPSSIKELTQL HEECCCHHHHHHHHH	35.42	20068231
129	Phosphorylation	LTQLTELYLYSNKLQ HHHHHHHHHHCCCCC	9.43	22210691
131	Phosphorylation	QLTELYLYSNKLQSL HHHHHHHHCCCCCCC	9.17	22210691
132	Phosphorylation	LTELYLYSNKLQSLP HHHHHHHCCCCCCCC	25.54	22210691
212	Ubiquitination	TTVEKDIKNLSKLSM CCHHHHHHHHHHHHH	63.07	29967540
221	Phosphorylation	LSKLSMLSIRENKIK HHHHHHHHHHHHHHH	15.80	21712546
297	Phosphorylation	GLRYNRLSAIPRSLA CCCHHHHCCCCHHHH	22.40	24719451
323	Ubiquitination	NNNISTLPESLLSSL CCCCCCCCHHHHHHH	29.26	23000965
337	Ubiquitination	LVKLNSLTLARNCFQ HHHHCHHHHHHHCEE	20.42	29967540
337	Phosphorylation	LVKLNSLTLARNCFQ HHHHCHHHHHHHCEE	20.42	24719451
369	Ubiquitination	MEHNRINKIPFGIFS CCCCCCCCCCCCHHH	49.76	23000965
376	Phosphorylation	KIPFGIFSRAKVLSK CCCCCHHHHHHHHHH	29.43	-
383	Ubiquitination	SRAKVLSKLNMKDNQ HHHHHHHHCCCCCCC	39.45	29967540
393	Ubiquitination	MKDNQLTSLPLDFGT CCCCCCCCCCCCCCC	36.26	29967540
413	Ubiquitination	ELNLATNQLTKIPED HHHHCCCCCCCCCCC	46.27	29967540
425	Ubiquitination	PEDVSGLVSLEVLIL CCCCCHHCHHHHHHH	7.57	29967540
429	Ubiquitination	SGLVSLEVLILSNNL CHHCHHHHHHHCCCH	4.96	29967540
439	Ubiquitination	LSNNLLKKLPHGLGN HCCCHHHHCCCCCCC	68.19	29967540
459	Ubiquitination	ELDLEENKLESLPNE HCCCCCCHHHCCCHH	57.84	29967540
471	Ubiquitination	PNEIAYLKDLQKLVL CHHHHHHHHHHHHHH	43.65	29967540
475	Ubiquitination	AYLKDLQKLVLTNNQ HHHHHHHHHHHCCCC	48.11	29967540
507	Phosphorylation	GLGENLLTHLPEEIG CCCHHHHHCCCHHHC	25.24	-
566	Phosphorylation	QIVAGGPSFIIQFLK CCCCCCCHHHHHHHH	32.14	-
578	Phosphorylation	FLKMQGPYRAMV--- HHHHCCCCCCCC---	20.16	21609022

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
71	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
297	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
297	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:30865892

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHOC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHOC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RASH_HUMAN	HRAS	physical	10783161
RAF1_HUMAN	RAF1	physical	10783161
A4_HUMAN	APP	physical	21832049
HUWE1_HUMAN	HUWE1	physical	25022756
PRS8_HUMAN	PSMC5	physical	26519477
RASM_HUMAN	MRAS	physical	26519477
HUWE1_HUMAN	HUWE1	physical	26519477
RAF1_HUMAN	RAF1	physical	26519477

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607721: Noonan syndrome-like disorder with loose anagen hair (NSLH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.