| UniProt ID | DTX4_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y2E6 | |
| Protein Name | E3 ubiquitin-protein ligase DTX4 | |
| Gene Name | DTX4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 619 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.. | |
| Protein Sequence | MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 161 | Phosphorylation | RRRLDLIYPMVTGTL HHHHHHHHHHCCCCC | 7.80 | 27461979 | |
| 165 | Phosphorylation | DLIYPMVTGTLPKAQ HHHHHHCCCCCCCHH | 20.42 | 27461979 | |
| 167 | Phosphorylation | IYPMVTGTLPKAQSW HHHHCCCCCCCHHCC | 30.44 | 27461979 | |
| 199 | Phosphorylation | PQCVLVMSVKAAVVN CCEEEEEEEEEEEEC | 17.00 | 24719451 | |
| 243 | Phosphorylation | GAKPLDSTGTIRGPL CCCCCCCCCCCCCCC | 37.70 | - | |
| 245 | Phosphorylation | KPLDSTGTIRGPLKT CCCCCCCCCCCCCCC | 13.95 | - | |
| 252 | Phosphorylation | TIRGPLKTAPSQVIR CCCCCCCCCHHHHHH | 52.03 | 23403867 | |
| 270 | Phosphorylation | SSMPTGTTMGSPASP HCCCCCCCCCCCCCC | 22.37 | - | |
| 273 | Phosphorylation | PTGTTMGSPASPPGP CCCCCCCCCCCCCCC | 13.38 | 23612710 | |
| 276 | Phosphorylation | TTMGSPASPPGPNSK CCCCCCCCCCCCCCC | 34.70 | 26657352 | |
| 282 | Phosphorylation | ASPPGPNSKTGRVAL CCCCCCCCCCCCEEE | 34.43 | 23612710 | |
| 284 | Phosphorylation | PPGPNSKTGRVALAT CCCCCCCCCCEEEEE | 30.00 | 23612710 | |
| 311 | Phosphorylation | QSRVLIASGVPTVPV HCCEEEECCCCCCCC | 33.07 | - | |
| 315 | Phosphorylation | LIASGVPTVPVKNLN EEECCCCCCCCCCCC | 34.73 | - | |
| 362 | Phosphorylation | VLHPPPVSKSEIKSI EECCCCCCHHHHCCC | 35.92 | 27174698 | |
| 364 | Phosphorylation | HPPPVSKSEIKSIPG CCCCCCHHHHCCCCC | 36.73 | 27174698 | |
| 376 | Phosphorylation | IPGVSNTSRKTTKKQ CCCCCCCCCCCCHHH | 35.71 | 18187866 | |
| 438 | Phosphorylation | PDLVGKLSRCGHVYH HHHHHHHHHCCCEEE | 29.07 | 20873877 | |
| 447 | Phosphorylation | CGHVYHIYCLVAMYN CCCEEEEEEEEECCC | 2.65 | - | |
| 453 | Phosphorylation | IYCLVAMYNNGNKDG EEEEEECCCCCCCCC | 8.85 | - | |
| 505 | Phosphorylation | CKTIRIIYSIPPGIQ CCEEEEEEECCCCCC | 9.74 | - | |
| 506 | Phosphorylation | KTIRIIYSIPPGIQG CEEEEEEECCCCCCC | 20.43 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DTX4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DTX4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DTX4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NALP4_HUMAN | NLRP4 | physical | 22388039 | |
| TBK1_HUMAN | TBK1 | physical | 22388039 | |
| NOTC1_HUMAN | NOTCH1 | physical | 28611181 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, AND MASSSPECTROMETRY. | |
