NALP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NALP4_HUMAN
• UniProt AC: Q96MN2
• Protein Name: NACHT, LRR and PYD domains-containing protein 4
• Gene Name: NLRP4
• Organism: Homo sapiens (Human).
• Sequence Length: 994
• Protein Description: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways..
• Protein Sequence: MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITRVEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	KEHLKQMTLQLELKQ HHHHHHHHHHHHHHH	14.62	27470641
72	Phosphorylation	EQQAWNITLRIFQKM HHHHHHHHHHHHHHC	13.53	24719451
93	Phosphorylation	MKVMRERTGYTKTYQ HHHHHHHHCCCHHHH	29.77	26074081
95	Phosphorylation	VMRERTGYTKTYQAH HHHHHHCCCHHHHHH	12.40	26074081
96	Phosphorylation	MRERTGYTKTYQAHA HHHHHCCCHHHHHHH	20.46	26074081
263	Phosphorylation	PVQVLLSSLLRKKML HHHHHHHHHHHHCCC	31.24	24719451
294	Phosphorylation	LRDQVTISEIYQPRG HHCCCCHHEECCCCC	14.47	24719451
297	Phosphorylation	QVTISEIYQPRGFNE CCCHHEECCCCCCCH	14.38	24719451
446	Phosphorylation	LKYGERESSYVFLHV HHCCCCCCCCHHHHH	32.94	25072903
447	Phosphorylation	KYGERESSYVFLHVC HCCCCCCCCHHHHHH	22.14	25072903
448	Phosphorylation	YGERESSYVFLHVCI CCCCCCCCHHHHHHH	12.42	25072903
464	Phosphorylation	EFCAALFYLLKSHLD HHHHHHHHHHHHCCC	16.39	25072903
601	Ubiquitination	KYCSSLRKLCFSVQN HHHHHHHHHHHHHHH	55.70	-
605	Phosphorylation	SLRKLCFSVQNVFKK HHHHHHHHHHHHHCC	23.07	-
611	Acetylation	FSVQNVFKKEDEHSS HHHHHHHCCCCCCCC	51.47	90859
808	Phosphorylation	EMLLRNKSVRYLDLS HHHHHCCCCEEEECC	18.51	30206219
811	Phosphorylation	LRNKSVRYLDLSANV HHCCCCEEEECCHHH	11.47	30206219
815	Phosphorylation	SVRYLDLSANVLKDE CCEEEECCHHHHCHH	19.91	30206219
960	Phosphorylation	QVLGLRKTDFDEETQ HHHCCCCCCCCHHHH	35.15	23403867
988	Phosphorylation	TITDDCDTITRVEI- EECCCCCCCEEEEC-	30.49	23403867
990	Phosphorylation	TDDCDTITRVEI--- CCCCCCCEEEEC---	30.65	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NALP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NALP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NALP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBK1_HUMAN	TBK1	physical	22388039
HS90A_HUMAN	HSP90AA1	physical	17435760
SGT1_HUMAN	SUGT1	physical	17435760

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.