KPSH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPSH2_HUMAN
• UniProt AC: Q96QS6
• Protein Name: Serine/threonine-protein kinase H2
• Gene Name: PSKH2
• Organism: Homo sapiens (Human).
• Sequence Length: 385
• Protein Sequence: MGCGASRKVVPGPPALAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	DPRVLARYDIKALIG CHHHHHHCCHHHHHC	19.20	22817900
84	Phosphorylation	VVRVEQKTTKKPFAI EEEEEECCCCCCEEE	43.47	22817900
85	Phosphorylation	VRVEQKTTKKPFAIK EEEEECCCCCCEEEE	44.07	22817900
110	Phosphorylation	EACVSELSVLRRVSH HHHHHHHHHHHHHCH	18.30	24719451
141	Phosphorylation	YMVMELATGGELFDR EEEEEHHHCCHHHHH	59.34	-
322	Phosphorylation	LDHPWVITMAAGSSM CCCCCEEEECCCCHH	7.37	22210691
327	Phosphorylation	VITMAAGSSMKNLQR EEEECCCCHHHHHHH	23.64	22210691
345	Phosphorylation	RNLMQRASPHSQSPG HHHHHHCCCCCCCCC	25.90	32142685
348	Phosphorylation	MQRASPHSQSPGSAQ HHHCCCCCCCCCCCC	35.42	29978859
350	Phosphorylation	RASPHSQSPGSAQSS HCCCCCCCCCCCCHH	33.95	29978859
353	Phosphorylation	PHSQSPGSAQSSKSH CCCCCCCCCCHHHCC	26.90	29978859
356	Phosphorylation	QSPGSAQSSKSHYSH CCCCCCCHHHCCCCH	39.18	29978859
357	Phosphorylation	SPGSAQSSKSHYSHK CCCCCCHHHCCCCHH	26.54	29978859
359	Phosphorylation	GSAQSSKSHYSHKSR CCCCHHHCCCCHHHH	29.61	29978859
361	Phosphorylation	AQSSKSHYSHKSRHM CCHHHCCCCHHHHHC	21.40	29978859
362	Phosphorylation	QSSKSHYSHKSRHMW CHHHCCCCHHHHHCC	21.00	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPSH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPSH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPSH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U119A_HUMAN	UNC119	physical	26186194
U119B_HUMAN	UNC119B	physical	26186194
HS90A_HUMAN	HSP90AA1	physical	26186194
HS90B_HUMAN	HSP90AB1	physical	26186194
FKBP5_HUMAN	FKBP5	physical	26186194
CDC37_HUMAN	CDC37	physical	26186194
YTHD1_HUMAN	YTHDF1	physical	26186194
PGTB2_HUMAN	RABGGTB	physical	26186194
FKBP5_HUMAN	FKBP5	physical	28514442
PGTB2_HUMAN	RABGGTB	physical	28514442
U119A_HUMAN	UNC119	physical	28514442
CDC37_HUMAN	CDC37	physical	28514442
HS90B_HUMAN	HSP90AB1	physical	28514442
U119B_HUMAN	UNC119B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.