STYK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STYK1_HUMAN
• UniProt AC: Q6J9G0
• Protein Name: Tyrosine-protein kinase STYK1
• Gene Name: STYK1
• Organism: Homo sapiens (Human).
• Sequence Length: 422
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)..
• Protein Sequence: MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYSML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGMTRMLLECS ----CCCHHHHHHCC	13.75	29116813
13	Phosphorylation	MLLECSLSDKLCVIQ HHHHCCCCCCEEEEE	19.19	29116813
15	Ubiquitination	LECSLSDKLCVIQEK HHCCCCCCEEEEECC	40.17	27667366
59	Phosphorylation	QRTQQQRSGPQGIAP HHHHHHHCCCCCCCC	50.95	-
74	Phosphorylation	VPPPRDLSWEAGHGG CCCCCCCCCCCCCCC	27.45	26657352
88	Ubiquitination	GNVALPLKETSVENF CCCEEECCCCCHHHH	57.94	-
90	Phosphorylation	VALPLKETSVENFLG CEEECCCCCHHHHHC	36.16	20886841
91	Phosphorylation	ALPLKETSVENFLGA EEECCCCCHHHHHCC	28.64	20886841
105	Ubiquitination	ATTPALAKLQVPREQ CCCHHHHHCCCCHHH	40.06	22817900
147	Ubiquitination	KPKSVILKALKEPAG CCHHHHHHHHCCCCC	40.32	27667366
191	Phosphorylation	CTEKLPLYMVLEDVA CCCCCCCEEEEEHHH	5.35	-
215	Phosphorylation	TCRRDVMTMDGLLYD HHCCCCEECCCCEEE	16.38	24732914
221	Phosphorylation	MTMDGLLYDLTEKQV EECCCCEEECCHHHH	17.60	24732914
224	Phosphorylation	DGLLYDLTEKQVYHI CCCEEECCHHHHHHH	37.93	24732914
274	Phosphorylation	LCGLGLAYEVYTRGA HHCCCCEEEEECCCC	15.80	29083192
277	Phosphorylation	LGLAYEVYTRGAISS CCCEEEEECCCCCCC	4.45	29083192
278	Phosphorylation	GLAYEVYTRGAISST CCEEEEECCCCCCCC	28.00	29083192
283	Phosphorylation	VYTRGAISSTQTIPL EECCCCCCCCCCCCC	27.14	29116813
284	Phosphorylation	YTRGAISSTQTIPLK ECCCCCCCCCCCCCC	20.58	29116813
285	Phosphorylation	TRGAISSTQTIPLKW CCCCCCCCCCCCCCH	23.96	29116813
287	Phosphorylation	GAISSTQTIPLKWLA CCCCCCCCCCCCHHC	25.34	24719451
304	Phosphorylation	RLLLRPASIRADVWS HHCCCCHHHHHHHHH	18.45	29396449
350	Phosphorylation	KIMKRPSSCTHTMYS CCCCCCCCCHHHHHH	26.22	19845377
352	Phosphorylation	MKRPSSCTHTMYSIM CCCCCCCHHHHHHHH	23.48	19845377
356	Phosphorylation	SSCTHTMYSIMKSCW CCCHHHHHHHHHHHH	9.01	19845377
372	Phosphorylation	WREADRPSPRELRLR HHHCCCCCHHHHHHH	37.17	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STYK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STYK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STYK1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of STYK1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.