FBXL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL2_HUMAN
• UniProt AC: Q9UKC9
• Protein Name: F-box/LRR-repeat protein 2 {ECO:0000305}
• Gene Name: FBXL2 {ECO:0000312|HGNC:HGNC:13598}
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Description: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). [PubMed: 22020328]
• Protein Sequence: MVFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCCVIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVFSNNDEGLI ----CCCCCCCCCCC	24.26	25159151
13	Ubiquitination	NDEGLINKKLPKELL CCCCCCCCCCCHHHH	49.01	29967540
74	Ubiquitination	RVVENISKRCGGFLR CHHCHHHHHCCHHHH	48.16	-
84	Phosphorylation	GGFLRKLSLRGCIGV CHHHHHCCCCCCCCC	21.03	24719451
201	Ubiquitination	QLEDEALKHIQNYCH CCHHHHHHHHHHHHH	45.79	-
326	Phosphorylation	LSHCELITDDGILHL CCCCEEECCCCEEEC	40.43	30576142
334	Phosphorylation	DDGILHLSNSTCGHE CCCEEECCCCCCCCC	20.27	30576142
399	Phosphorylation	PHVKVHAYFAPVTPP CCCEEEEEECCCCCC	5.84	23403867
404	Phosphorylation	HAYFAPVTPPTAVAG EEEECCCCCCCCCCC	23.61	30266825
407	Phosphorylation	FAPVTPPTAVAGSGQ ECCCCCCCCCCCCCC	34.66	23403867
412	Phosphorylation	PPTAVAGSGQRLCRC CCCCCCCCCCEEEEE	23.24	23403867
420	Geranylgeranylation	GQRLCRCCVIL---- CCEEEEEEEEC----	0.80	15893726
420	Geranylgeranylation	GQRLCRCCVIL---- CCEEEEEEEEC----	0.80	15893726

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	22399757
CUL1_HUMAN	CUL1	physical	22399757
A4_HUMAN	APP	physical	22399757
SKP1_HUMAN	SKP1	physical	10508920
CCND2_HUMAN	CCND2	physical	22323446
AURKB_HUMAN	AURKB	physical	23370391
P85A_HUMAN	PIK3R1	physical	23604317
P85B_HUMAN	PIK3R2	physical	23604317
SKP1_HUMAN	SKP1	physical	23604317
CUL2_HUMAN	CUL2	physical	23604317
UB2R1_HUMAN	CDC34	physical	23604317
UB2D3_HUMAN	UBE2D3	physical	23604317
PTN13_HUMAN	PTPN13	physical	23604317
PGTB2_HUMAN	RABGGTB	physical	24035498
NLRP3_HUMAN	NLRP3	physical	26037928
UB2D1_HUMAN	UBE2D1	physical	26037928
UB2G1_HUMAN	UBE2G1	physical	26037928
FOXM1_HUMAN	FOXM1	physical	26790640
SKP1_HUMAN	SKP1	physical	26790640
CUL1_HUMAN	CUL1	physical	26790640
ITPR3_HUMAN	ITPR3	physical	28614300
SKP1_HUMAN	SKP1	physical	28614300
CUL1_HUMAN	CUL1	physical	28614300
TERA_HUMAN	VCP	physical	28614300
FBX3_HUMAN	FBXO3	physical	27010866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.