FBX9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX9_HUMAN
• UniProt AC: Q9UK97
• Protein Name: F-box only protein 9
• Gene Name: FBXO9
• Organism: Homo sapiens (Human).
• Sequence Length: 447
• Subcellular Localization: Cytoplasm .
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1..
• Protein Sequence: MPDIIWVFPPQAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVSAFEIDKMYTPLFFARVRSYTAFSERPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 2)	Phosphorylation	-	34.25	24719451
20	Phosphorylation	EAEEDCHSDTVRADD HHCCCCCCCCCCCCC	41.11	23663014
33	Ubiquitination	DDDEENESPAETDLQ CCCCCCCCCHHHHHH	40.78	29967540
33	Phosphorylation	DDDEENESPAETDLQ CCCCCCCCCHHHHHH	40.78	27732954
37	Phosphorylation	ENESPAETDLQAQLQ CCCCCHHHHHHHHHH	44.08	26471730
41	Ubiquitination	PAETDLQAQLQMFRA CHHHHHHHHHHHHHH	21.24	24816145
67	Ubiquitination	SSNLENRPCRAARGS CCCCCCCCCHHHHHC	24.43	29967540
71 (in isoform 3)	Ubiquitination	-	9.30	21890473
71	Ubiquitination	ENRPCRAARGSLQKT CCCCCHHHHHCCCCC	9.30	21890473
74	Phosphorylation	PCRAARGSLQKTSAD CCHHHHHCCCCCCCC	23.29	28102081
75	Ubiquitination	CRAARGSLQKTSADT CHHHHHCCCCCCCCC	7.24	24816145
77	Ubiquitination	AARGSLQKTSADTKG HHHHCCCCCCCCCCC	50.14	29967540
85	Ubiquitination	TSADTKGKQEQAKEE CCCCCCCHHHHHHHH	52.82	24816145
105 (in isoform 2)	Ubiquitination	-	35.52	21890473
105	Ubiquitination	FLKAVEEEQNGALYE HHHHHHHHHCCHHHH	35.52	21890473
111	Phosphorylation	EEQNGALYEAIKFYR HHHCCHHHHHHHHHH	11.63	21945579
115 (in isoform 1)	Ubiquitination	-	43.31	21890473
115	Ubiquitination	GALYEAIKFYRRAMQ CHHHHHHHHHHHHHH	43.31	21890473
115	Acetylation	GALYEAIKFYRRAMQ CHHHHHHHHHHHHHH	43.31	18603043
115	Ubiquitination	GALYEAIKFYRRAMQ CHHHHHHHHHHHHHH	43.31	22817900
121	Sulfoxidation	IKFYRRAMQLVPDIE HHHHHHHHHHCCCEE	2.76	21406390
130	Acetylation	LVPDIEFKITYTRSP HCCCEEEEEEEEECC	22.73	18603053
132	Phosphorylation	PDIEFKITYTRSPDG CCEEEEEEEEECCCC	21.30	28450419
133	Phosphorylation	DIEFKITYTRSPDGD CEEEEEEEEECCCCC	12.02	28450419
134	Phosphorylation	IEFKITYTRSPDGDG EEEEEEEEECCCCCC	18.93	28450419
136	Phosphorylation	FKITYTRSPDGDGVG EEEEEEECCCCCCCC	21.39	25159151
145	Phosphorylation	DGDGVGNSYIEDNDD CCCCCCCCCCCCCCC	22.89	23186163
195 (in isoform 2)	Phosphorylation	-	2.79	24719451
205	Phosphorylation	YIFRWVVSSDLDLRS HHHHHHHCCCCCCCC	14.44	24719451
207 (in isoform 2)	Phosphorylation	-	36.37	24719451
217	Phosphorylation	LRSLEQLSLVCRGFY CCCHHHHHHHHHEEE	20.60	24719451
266 (in isoform 2)	Phosphorylation	-	9.79	24719451
276	Phosphorylation	VYISKTTYIRQGEQS EEEECCEEEEECCCC	10.19	24719451
296	Phosphorylation	RAWHQVEYYRYIRFF HHHHHHEEEEEEEEC	8.39	-
297	Phosphorylation	AWHQVEYYRYIRFFP HHHHHEEEEEEEECC	5.39	-
345	Phosphorylation	HYRLSQDTDNQTKVF EEEECCCCCCCEEEE	29.25	22210691
349	Phosphorylation	SQDTDNQTKVFAVIT CCCCCCCEEEEEEEE	35.12	22210691
429	Phosphorylation	FEIDKMYTPLFFARV EEECCCCCCCHHHHH	15.26	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	17463251
EF2_HUMAN	EEF2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.