KLH14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH14_HUMAN
• UniProt AC: Q9P2G3
• Protein Name: Kelch-like protein 14
• Gene Name: KLHL14
• Organism: Homo sapiens (Human).
• Sequence Length: 628
• Subcellular Localization: Cytoplasm, cytosol . Endoplasmic reticulum membrane . Colocalizes with TOR1A at the endoplasmic reticulum level.
• Protein Sequence: MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACVTVILPSCVPYNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
131	Phosphorylation	NLVLQGCSSIGLRLV HHHHCCCCHHHHHHH	31.64	23312004
132	Phosphorylation	LVLQGCSSIGLRLVL HHHCCCCHHHHHHHH	25.42	24719451
159	Phosphorylation	DTVEEVLSVSKILHI CCHHHHHCHHHHHCC	29.53	24719451
319	Phosphorylation	SLASRIRSNKKMLLL HHHHHHHCCCCEEEE	51.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOR1A_HUMAN	TOR1A	physical	19535332
FXL17_HUMAN	FBXL17	physical	26186194
FAD1_HUMAN	FLAD1	physical	26186194
NUDC3_HUMAN	NUDCD3	physical	26186194
KLH26_HUMAN	KLHL26	physical	26186194
KCD21_HUMAN	KCTD21	physical	26186194
KCD21_HUMAN	KCTD21	physical	28514442
KLH26_HUMAN	KLHL26	physical	28514442
FXL17_HUMAN	FBXL17	physical	28514442
FAD1_HUMAN	FLAD1	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.