| UniProt ID | KCNQ4_HUMAN | |
|---|---|---|
| UniProt AC | P56696 | |
| Protein Name | Potassium voltage-gated channel subfamily KQT member 4 | |
| Gene Name | KCNQ4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 695 | |
| Subcellular Localization |
Basal cell membrane Multi-pass membrane protein. Situated at the basal membrane of cochlear outer hair cells.. |
|
| Protein Description | Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.. | |
| Protein Sequence | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 31 | Phosphorylation | VALTAVQSEQGEAGG EEEEEEECCCCCCCC | 25.86 | 28348404 | |
| 41 | Phosphorylation | GEAGGGGSPRRLGLL CCCCCCCCCCCCCCC | 20.64 | 28348404 | |
| 223 | Phosphorylation | RMDRRGGTWKLLGSV HCCCCCCCCHHHEEH | 23.42 | 16319223 | |
| 235 | Phosphorylation | GSVVYAHSKELITAW EEHHHHCCHHHHHHH | 21.47 | - | |
| 353 | Phosphorylation | IQAAWRLYSTDMSRA HHHHHHHHCCCCCCH | 10.84 | 30257219 | |
| 361 (in isoform 2) | Phosphorylation | - | 11.95 | 25072903 | |
| 363 (in isoform 2) | Phosphorylation | - | 14.90 | 25072903 | |
| 365 (in isoform 2) | Phosphorylation | - | 14.57 | 25072903 | |
| 367 (in isoform 2) | Phosphorylation | - | 6.44 | 25072903 | |
| 368 (in isoform 2) | Phosphorylation | - | 7.74 | 25072903 | |
| 369 (in isoform 2) | Phosphorylation | - | 6.37 | 25072903 | |
| 371 (in isoform 2) | Phosphorylation | - | 15.20 | 25072903 | |
| 460 | Phosphorylation | KQHLAPPTMPTSPSS CCCCCCCCCCCCCCH | 34.42 | 22210691 | |
| 467 | Phosphorylation | TMPTSPSSEQVGEAT CCCCCCCHHHCCCCC | 35.12 | 22210691 | |
| 475 | Phosphorylation | EQVGEATSPTKVQKS HHCCCCCCCCCCCCC | 37.31 | - | |
| 477 | Phosphorylation | VGEATSPTKVQKSWS CCCCCCCCCCCCCCC | 43.55 | - | |
| 482 | Phosphorylation | SPTKVQKSWSFNDRT CCCCCCCCCCCCCCC | 15.74 | 30266825 | |
| 484 | Phosphorylation | TKVQKSWSFNDRTRF CCCCCCCCCCCCCCC | 22.66 | 23401153 | |
| 494 | Phosphorylation | DRTRFRASLRLKPRT CCCCCEEEEECCCCC | 15.12 | 26437602 | |
| 552 | Phosphorylation | AKRKFKETLRPYDVK HHHHHHHCCCCCCHH | 28.76 | 22817900 | |
| 565 | Phosphorylation | VKDVIEQYSAGHLDM HHHHHHHHCHHCHHH | 6.41 | 28111955 | |
| 566 | Phosphorylation | KDVIEQYSAGHLDML HHHHHHHCHHCHHHH | 27.71 | 28111955 | |
| 678 | Phosphorylation | PVDHEDISVSAQTLS CCCHHHCCEEEEEEE | 23.49 | - | |
| 685 | Phosphorylation | SVSAQTLSISRSVST CEEEEEEEEEECCCC | 23.16 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCNQ4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNQ4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNQ4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HS90A_HUMAN | HSP90AA1 | physical | 23431407 | |
| ENPL_HUMAN | HSP90B1 | physical | 23431407 | |
| DNJA1_HUMAN | DNAJA1 | physical | 23431407 | |
| HSP7C_HUMAN | HSPA8 | physical | 23431407 | |
| STIP1_HUMAN | STIP1 | physical | 23431407 | |
| CHIP_HUMAN | STUB1 | physical | 23431407 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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