TBX22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBX22_HUMAN
• UniProt AC: Q9Y458
• Protein Name: T-box transcription factor TBX22
• Gene Name: TBX22
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis..
• Protein Sequence: MALSSRARAFSVEALVGRPSKRKLQDPIQAEQPELREKKGGEEEEERRSSAAGKSEPLEKQPKTEPSTSASSGCGSDSGYGNSSESLEEKDIQMELQGSELWKRFHDIGTEMIITKAGRRMFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMKLTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKGFRDTGRNRGVLDGLLETYPWRPSFTLDFKTFGADTQSGSSGSSPVTSSGGAPSPLNSLLSPLCFSPMFHLPTSSLGMPCPEAYLPNVNLPLCYKICPTNFWQQQPLVLPAPERLASSNSSQSLAPLMMEVPMLSSLGVTNSKSGSSEDSSDQYLQAPNSTNQMLYGLQSPGNIFLPNSITPEALSCSFHPSYDFYRYNFSMPSRLISGSNHLKVNDDSQVSFGEGKCNHVHWYPAINHYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	EEEEERRSSAAGKSE HHHHHHHHHCCCCCC	30.46	22210691
50	Phosphorylation	EEEERRSSAAGKSEP HHHHHHHHCCCCCCC	21.96	22210691
63	Sumoylation	EPLEKQPKTEPSTSA CCCCCCCCCCCCCCC	64.13	-
63	Sumoylation	EPLEKQPKTEPSTSA CCCCCCCCCCCCCCC	64.13	-
68	Phosphorylation	QPKTEPSTSASSGCG CCCCCCCCCCCCCCC	38.74	-
69	Phosphorylation	PKTEPSTSASSGCGS CCCCCCCCCCCCCCC	30.41	-
72	Phosphorylation	EPSTSASSGCGSDSG CCCCCCCCCCCCCCC	37.51	-
78	Phosphorylation	SSGCGSDSGYGNSSE CCCCCCCCCCCCCCH	35.29	-
83	Phosphorylation	SDSGYGNSSESLEEK CCCCCCCCCHHHHHH	30.99	-
84	Phosphorylation	DSGYGNSSESLEEKD CCCCCCCCHHHHHHH	34.89	-
86	Phosphorylation	GYGNSSESLEEKDIQ CCCCCCHHHHHHHHH	42.92	-
138	Phosphorylation	GLDPGKQYHVAIDVV CCCCCCEEEEEEEEE	11.18	-
216	Phosphorylation	KGHIILQSMHKYKPR CCCEEEECCHHCCCC	21.29	26126808
220	Phosphorylation	ILQSMHKYKPRVHVI EEECCHHCCCCEEEE	16.14	25278378
231	Phosphorylation	VHVIEQGSSVDLSQI EEEEECCCCCCHHHH	27.21	25278378
232	Phosphorylation	HVIEQGSSVDLSQIQ EEEECCCCCCHHHHC	26.86	25278378
236	Phosphorylation	QGSSVDLSQIQSLPT CCCCCCHHHHCCCCC	22.30	25278378
240	Phosphorylation	VDLSQIQSLPTEGVK CCHHHHCCCCCCCCC	37.64	25278378
243	Phosphorylation	SQIQSLPTEGVKTFS HHHCCCCCCCCCEEE	51.14	25278378
248	Phosphorylation	LPTEGVKTFSFKETE CCCCCCCEEEEECCE	23.31	25278378
250	Phosphorylation	TEGVKTFSFKETEFT CCCCCEEEEECCEEE	40.41	24719451
268	Phosphorylation	AYQNQQITKLKIERN EECCCEEEEEEEECC	26.45	-
271	Sumoylation	NQQITKLKIERNPFA CCEEEEEEEECCCCC	44.04	-
271	Sumoylation	NQQITKLKIERNPFA CCEEEEEEEECCCCC	44.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBX22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBX22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBX22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GOPC_HUMAN	GOPC	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 303400: Cleft palate with or without ankyloglossia, X-linked (CPX)
• 302905: Abruzzo-Erickson syndrome (ABERS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.