INSRR_HUMAN - dbPTM
INSRR_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INSRR_HUMAN
UniProt AC P14616
Protein Name Insulin receptor-related protein
Gene Name INSRR
Organism Homo sapiens (Human).
Sequence Length 1297
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB..
Protein Sequence MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVCPGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
47N-linked_GlycosylationAELRQLENCSVVEGH
HHHHCHHCCCEEECE		31.77UniProtKB CARBOHYD
72PhosphorylationGEDFRGLSFPRLTQV
CCCCCCCCCCCHHHH		35.7124719451
311N-linked_GlycosylationCPSGFTRNSSSIFCH
CCCCCCCCCCCCEEE		43.09UniProtKB CARBOHYD
411N-linked_GlycosylationGDAMVDGNYTLYVLD
CCEEECCCEEEEEEC		23.35UniProtKB CARBOHYD
492N-linked_GlycosylationRTLRFVSNVTEADRI
CCEEEECCCCHHHHH		39.15UniProtKB CARBOHYD
528N-linked_GlycosylationYKESPFQNATEHVGP
ECCCCCCCCCCCCCC		49.57UniProtKB CARBOHYD
542PhosphorylationPDACGTQSWNLLDVE
CCCCCCCCCCEEEEE		20.12-
553PhosphorylationLDVELPLSRTQEPGV
EEEECCCCCCCCCCE		31.20-
600PhosphorylationSPIVYLRTLPAAPTV
CCEEEEEECCCCCCC		34.2018767875
606PhosphorylationRTLPAAPTVPQDVIS
EECCCCCCCCCCCEE		39.8418767875
613PhosphorylationTVPQDVISTSNSSSH
CCCCCCEECCCCCCC		26.1518767875
614PhosphorylationVPQDVISTSNSSSHL
CCCCCEECCCCCCCE		22.3218767875
615PhosphorylationPQDVISTSNSSSHLL
CCCCEECCCCCCCEE		28.1118767875
616N-linked_GlycosylationQDVISTSNSSSHLLV
CCCEECCCCCCCEEE		46.10UniProtKB CARBOHYD
618PhosphorylationVISTSNSSSHLLVRW
CEECCCCCCCEEEEE		26.4818767875
619PhosphorylationISTSNSSSHLLVRWK
EECCCCCCCEEEEEC		20.2718767875
634N-linked_GlycosylationPPTQRNGNLTYYLVL
CCCCCCCCEEEEEEE		32.53UniProtKB CARBOHYD
756N-linked_GlycosylationGPLRLGGNSSDFEIQ
CCEECCCCCCCCCCC		36.22UniProtKB CARBOHYD
775PhosphorylationPRERAVLSGLRHFTE
HHHHHHHHHCCHHEE		29.2321815630
781PhosphorylationLSGLRHFTEYRIDIH
HHHCCHHEEEEEEHH		26.44-
783PhosphorylationGLRHFTEYRIDIHAC
HCCHHEEEEEEHHHC		15.15-
821SumoylationEADGIPGKVAWEASS
CCCCCCCCEEEEECC		24.35-
829SumoylationVAWEASSKNSVLLRW
EEEEECCCCEEEEEE		51.23-
885N-linked_GlycosylationLALLPPGNYSARVRA
EEEECCCCCCCEEEE		33.10UniProtKB CARBOHYD
898N-linked_GlycosylationRATSLAGNGSWTDSV
EEEECCCCCCEECEE		35.40UniProtKB CARBOHYD
994PhosphorylationQGSFGMVYEGLARGL
CCCCHHHHHHHHHHH		8.72-
1124PhosphorylationAARNCMVSQDFTVKI
HHCCCCCCCCEEEEE		9.35-
1128PhosphorylationCMVSQDFTVKIGDFG
CCCCCCEEEEECCCC		29.22-
1145PhosphorylationRDVYETDYYRKGGKG
CCEEECCCCCCCCCC		16.76-
1146PhosphorylationDVYETDYYRKGGKGL
CEEECCCCCCCCCCC		14.52-
1151UbiquitinationDYYRKGGKGLLPVRW
CCCCCCCCCCCCEEE		55.8621987572
1271PhosphorylationECRGARGSLPTTDAE
HHCCCCCCCCCCCCC		26.14-
1284PhosphorylationAEPDSSPTPRDCSPQ
CCCCCCCCCCCCCCC		32.67-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INSRR_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INSRR_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INSRR_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CTDS2_HUMANCTDSP2physical
28065597
STYX_HUMANSTYXphysical
28065597
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INSRR_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory