| UniProt ID | CTDS2_HUMAN | |
|---|---|---|
| UniProt AC | O14595 | |
| Protein Name | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 | |
| Gene Name | CTDSP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 271 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.. | |
| Protein Sequence | MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCCFRAQHVGQSSSSTELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQLRAP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MEHGSIITQARR ---CCCCCHHCCCHH | 16.84 | 28857561 | |
| 20 | Ubiquitination | EDALVLTKQGLVSKS HHCEEEECCCCCCCC | 37.90 | - | |
| 26 | Ubiquitination | TKQGLVSKSSPKKPR ECCCCCCCCCCCCCC | 47.69 | - | |
| 53 | Phosphorylation | RAQHVGQSSSSTELA HHHHCCCCCCHHHHH | 26.68 | 28450419 | |
| 54 | Phosphorylation | AQHVGQSSSSTELAA HHHCCCCCCHHHHHH | 22.03 | 26657352 | |
| 55 | Phosphorylation | QHVGQSSSSTELAAY HHCCCCCCHHHHHHH | 46.67 | 25849741 | |
| 56 | Phosphorylation | HVGQSSSSTELAAYK HCCCCCCHHHHHHHH | 28.05 | 28450419 | |
| 57 | Phosphorylation | VGQSSSSTELAAYKE CCCCCCHHHHHHHHH | 36.65 | 28450419 | |
| 62 | Phosphorylation | SSTELAAYKEEANTI CHHHHHHHHHHHHHH | 17.21 | 28450419 | |
| 63 | Ubiquitination | STELAAYKEEANTIA HHHHHHHHHHHHHHC | 44.33 | - | |
| 68 | Phosphorylation | AYKEEANTIAKSDLL HHHHHHHHHCHHHHH | 29.38 | 23312004 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CTDS2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTDS2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTDS2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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