| UniProt ID | ACV1C_HUMAN | |
|---|---|---|
| UniProt AC | Q8NER5 | |
| Protein Name | Activin receptor type-1C | |
| Gene Name | ACVR1C {ECO:0000312|HGNC:HGNC:18123} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 493 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.. | |
| Protein Sequence | MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTRALCSAL ------CHHHHHHHH | 25.34 | 29083192 | |
| 7 | Phosphorylation | -MTRALCSALRQALL -CHHHHHHHHHHHHH | 31.05 | 29083192 | |
| 23 | Phosphorylation | LAAAAELSPGLKCVC HHHHHHCCCCCEEEE | 14.39 | 24719451 | |
| 147 | Acetylation | QCSYRKKKRPNVEEP CCCCCCCCCCCCCCC | 75.91 | 11688409 | |
| 165 | Acetylation | CNLVNAGKTLKDLIY CCCCCCCCCHHHHHE | 48.55 | 11688419 | |
| 168 | Acetylation | VNAGKTLKDLIYDVT CCCCCCHHHHHEEEC | 56.57 | 11688429 | |
| 172 | Phosphorylation | KTLKDLIYDVTASGS CCHHHHHEEECCCCC | 16.20 | 23607784 | |
| 175 | Phosphorylation | KDLIYDVTASGSGSG HHHHEEECCCCCCCC | 16.53 | 23607784 | |
| 177 | Phosphorylation | LIYDVTASGSGSGLP HHEEECCCCCCCCHH | 24.91 | 23607784 | |
| 179 | Phosphorylation | YDVTASGSGSGLPLL EEECCCCCCCCHHHH | 27.56 | 23607784 | |
| 181 | Phosphorylation | VTASGSGSGLPLLVQ ECCCCCCCCHHHHHH | 38.56 | 23607784 | |
| 190 | Phosphorylation | LPLLVQRTIARTIVL HHHHHHHHHHHHHHH | 11.25 | 23607784 | |
| 327 | Ubiquitination | AHRDIKSKNILVKKC ECCCCCCCCEEEEEC | 42.90 | - | |
| 368 | Phosphorylation | PKVGTKRYMAPEMLD CCCCCCCCCCHHHHC | 10.13 | 22468782 | |
| 377 | Phosphorylation | APEMLDDTMNVNIFE CHHHHCCCCCCCHHH | 15.43 | 22468782 | |
| 474 | Phosphorylation | ANGAARLTALRIKKT HCHHHHHHHHHHHHH | 20.35 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACV1C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACV1C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACV1C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ACV1C_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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