KPSH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPSH1_HUMAN
• UniProt AC: P11801
• Protein Name: Serine/threonine-protein kinase H1
• Gene Name: PSKH1
• Organism: Homo sapiens (Human).
• Sequence Length: 424
• Subcellular Localization: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Localized in the brefeldin A-sensitive Golgi compartment, at c
• Protein Description: May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing..
• Protein Sequence: MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGCGTSKVL ------CCCCCCCCC	20.68	-
2	Myristoylation	------MGCGTSKVL ------CCCCCCCCC	20.68	14644153
3	S-palmitoylation	-----MGCGTSKVLP -----CCCCCCCCCC	5.33	14644153
35	Phosphorylation	SGTKSDVYKHFITEV CCCCHHHHHHHCEEC	12.07	-
95	Phosphorylation	AKFDPRVTAKYDIKA HHCCCCCCEEEEHHH	20.79	28555341
164	Phosphorylation	QLVEVFETQERVYMV HHEEEEHHHCHHHHE	25.02	-
176	Phosphorylation	YMVMELATGGELFDR HHEEHHHHCCHHHHH	59.34	-
187	Ubiquitination	LFDRIIAKGSFTERD HHHHHHHCCCCCHHH	44.68	-
238	Phosphorylation	TDSKIIITDFGLASA CCCEEEEECCCHHHH	18.18	26074081
244	Phosphorylation	ITDFGLASARKKGDD EECCCHHHHHHCCCC	33.38	26074081
380	Phosphorylation	QNLLKRASSRCQSTK HHHHHHHHHHHHCCH	23.50	-
381	Phosphorylation	NLLKRASSRCQSTKS HHHHHHHHHHHCCHH	35.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPSH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPSH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPSH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90A_HUMAN	HSP90AA1	physical	22939624
RDH13_HUMAN	RDH13	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Mutants of the protein serine kinase PSKH1 disassemble the Golgiapparatus.";
Brede G., Solheim J., Stang E., Prydz H.;
Exp. Cell Res. 291:299-312(2003).
Cited for: MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-3, AND SUBCELLULARLOCATION.
PubMed: 14644153

Palmitoylation

"Mutants of the protein serine kinase PSKH1 disassemble the Golgiapparatus.";
Brede G., Solheim J., Stang E., Prydz H.;
Exp. Cell Res. 291:299-312(2003).
Cited for: MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-3, AND SUBCELLULARLOCATION.
PubMed: 14644153