FBX34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX34_HUMAN
• UniProt AC: Q9NWN3
• Protein Name: F-box only protein 34
• Gene Name: FBXO34
• Organism: Homo sapiens (Human).
• Sequence Length: 711
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHITSSVFPSASLGKASSRKPFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEEGPLDIWAVVKPGNTKEKIAFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKVQVERMREVNSRCYQPEPFACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRASALLASCSKNCTNSPAIVRFSGQSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEPVRVLDMVAKLESECLKRQGQREPGSLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLEAPDTQVNPVGSVSVDCGPSRADRCSPKEDQAWDGASQDCPPLPAGVSFHIDSAELEPGSQTAVKNSNRYDVEMTDELVGLPFSSHTYSQASELPTDAVDCMSRELVSLTSRNPDQRKESLCISITVSKVDKDQPSILNSCEDPVPGMLFFLPPGQHLSDYSQLNESTTKESSEASQLEDAAGGDSASEEKSGSAEPFVLPASSVESTLPVLEASSWKKQVSHDFLETRFKIQQLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHRSQKGFPGCKLGLHDNHWVPACHSFNRAIHKKAKGTEAEEEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	NDETCKASHITSSVF CHHHHHHHHHCHHHC	10.83	-
44	Phosphorylation	TCKASHITSSVFPSA HHHHHHHCHHHCCCC	14.99	23532336
45	Phosphorylation	CKASHITSSVFPSAS HHHHHHCHHHCCCCC	24.73	23532336
46	Phosphorylation	KASHITSSVFPSASL HHHHHCHHHCCCCCC	21.08	23532336
77	Phosphorylation	LCSMSGKSPVESSLN EEECCCCCCCCCCCC	37.39	23532336
81	Phosphorylation	SGKSPVESSLNVKTK CCCCCCCCCCCCCCC	40.12	-
82	Phosphorylation	GKSPVESSLNVKTKK CCCCCCCCCCCCCCC	15.51	-
86	Ubiquitination	VESSLNVKTKKNAPS CCCCCCCCCCCCCCC	54.26	-
87	Phosphorylation	ESSLNVKTKKNAPSA CCCCCCCCCCCCCCC	42.86	-
125	Phosphorylation	EKIAFFASHQCSNRI HHEEEEECCCCCCCC	14.66	-
129	Phosphorylation	FFASHQCSNRIGSMK EEECCCCCCCCCCCE	23.67	-
154	Phosphorylation	ATKRRKKSGDLKKAK CCCCCCCCCCHHHHH	40.34	-
227	Ubiquitination	ALLASCSKNCTNSPA HHHHHHCCCCCCCCE	61.44	-
227	Ubiquitination	ALLASCSKNCTNSPA HHHHHHCCCCCCCCE	61.44	-
288	Phosphorylation	DMVAKLESECLKRQG HHHHHHHHHHHHHCC	44.01	19413330
301	Phosphorylation	QGQREPGSLSRNNSF CCCCCCCCCCCCCHH	33.61	23532336
307	Phosphorylation	GSLSRNNSFRRNVGR CCCCCCCHHHHHHHH	24.55	26437602
457	Phosphorylation	RKESLCISITVSKVD HCEEEEEEEEEEECC	15.94	-
461	Phosphorylation	LCISITVSKVDKDQP EEEEEEEEECCCCCC	20.50	-
519	Phosphorylation	EDAAGGDSASEEKSG HHHCCCCCCCCCCCC	36.65	28985074
552	Ubiquitination	LEASSWKKQVSHDFL HHCCHHCHHCCHHHH	50.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX34_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX34_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	16169070
TGFR1_HUMAN	TGFBR1	physical	15761153
TGFR2_HUMAN	TGFBR2	physical	15761153
CUL1_HUMAN	CUL1	physical	22268729
K1C40_HUMAN	KRT40	physical	25416956
SKP1_HUMAN	SKP1	physical	26087183
MYO6_HUMAN	MYO6	physical	28514442
FBX30_HUMAN	FBXO30	physical	28514442
GELS_HUMAN	GSN	physical	28514442
TMOD3_HUMAN	TMOD3	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, AND MASSSPECTROMETRY.
PubMed: 19413330