| UniProt ID | RB40A_HUMAN | |
|---|---|---|
| UniProt AC | Q8WXH6 | |
| Protein Name | Ras-related protein Rab-40A | |
| Gene Name | RAB40A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 277 | |
| Subcellular Localization |
Cell membrane Lipid-anchor Cytoplasmic side . |
|
| Protein Description | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.. | |
| Protein Sequence | MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRMNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPSTLRSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKSSLCKVEIVCPPQSPPKNCTRNSCKIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | GDRDVGKSEILESLQ CCCCCCHHHHHHHHH | 24.76 | - | |
| 133 | Ubiquitination | NRLHLAFKRQVPREQ CCHHHHHHCCCCHHH | 35.99 | 21890473 | |
| 165 | Ubiquitination | LCNFNIIESFTELAR CCCCCHHHHHHHHHH | 35.68 | 21890473 | |
| 199 | Phosphorylation | LQDLCCRTIVSCTPV HHHHHHCHHHCCCCH | 16.30 | 25690035 | |
| 202 | Phosphorylation | LCCRTIVSCTPVHLV HHHCHHHCCCCHHHH | 14.39 | 25690035 | |
| 224 | Phosphorylation | TLRSHLKSFSMAKGL HHHHHHHHHHHHHCC | 28.99 | 30576142 | |
| 244 | Phosphorylation | RGLSYSLTTSSTHKS CCCCEECCCCCCCCC | 20.77 | 30576142 | |
| 264 | Phosphorylation | EIVCPPQSPPKNCTR EEECCCCCCCCCCCC | 49.28 | - | |
| 269 | S-palmitoylation | PQSPPKNCTRNSCKI CCCCCCCCCCCCCCC | 4.76 | - | |
| 274 | Geranylgeranylation | KNCTRNSCKIS---- CCCCCCCCCCC---- | 5.32 | - | |
| 274 | Methylation | KNCTRNSCKIS---- CCCCCCCCCCC---- | 5.32 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RB40A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RB40A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RB40A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BICL2_MOUSE | Ccdc64b | physical | 20360680 | |
| ELOC_HUMAN | TCEB1 | physical | 26186194 | |
| CUL5_HUMAN | CUL5 | physical | 26186194 | |
| CSN6_HUMAN | COPS6 | physical | 26186194 | |
| RB40L_HUMAN | RAB40AL | physical | 26186194 | |
| ISCA1_HUMAN | ISCA1 | physical | 26186194 | |
| LYRM7_HUMAN | LYRM7 | physical | 26186194 | |
| F192A_HUMAN | FAM192A | physical | 26186194 | |
| PSME3_HUMAN | PSME3 | physical | 26186194 | |
| ARI2_HUMAN | ARIH2 | physical | 26186194 | |
| RB40L_HUMAN | RAB40AL | physical | 28514442 | |
| ISCA1_HUMAN | ISCA1 | physical | 28514442 | |
| CUL5_HUMAN | CUL5 | physical | 28514442 | |
| ELOC_HUMAN | TCEB1 | physical | 28514442 | |
| F192A_HUMAN | FAM192A | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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