PIM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIM3_HUMAN
• UniProt AC: Q86V86
• Protein Name: Serine/threonine-protein kinase pim-3
• Gene Name: PIM3
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Subcellular Localization: Cytoplasm .
• Protein Description: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth..
• Protein Sequence: MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MLLSKFGSLAHL ---CCCCCCCHHHHH	54.43	-
8	Phosphorylation	MLLSKFGSLAHLCGP CCCCCCCHHHHHCCC	26.05	25850435
24	Ubiquitination	GVDHLPVKILQPAKA CCCCCCHHHCCCCCC	35.44	32015554
30	Ubiquitination	VKILQPAKADKESFE HHHCCCCCCCHHHHH	64.89	21906983
33	Ubiquitination	LQPAKADKESFEKAY CCCCCCCHHHHHHHH	61.18	22817900
38	Ubiquitination	ADKESFEKAYQVGAV CCHHHHHHHHHHHCE	50.84	21906983
69	Ubiquitination	DGLPVAVKHVVKERV CCCCEEEHHHHHHHH	22.42	21906983
73	Ubiquitination	VAVKHVVKERVTEWG EEEHHHHHHHHCCCC	38.42	22817900
77	Phosphorylation	HVVKERVTEWGSLGG HHHHHHHCCCCCCCC	32.04	-
81	Phosphorylation	ERVTEWGSLGGATVP HHHCCCCCCCCCEEE	25.55	-
86	Phosphorylation	WGSLGGATVPLEVVL CCCCCCCEEEEEEEE	26.40	-
96	Ubiquitination	LEVVLLRKVGAAGGA EEEEEHHHHCCCCCH	45.02	22053931
172	Ubiquitination	GVVHRDIKDENLLVD CCCCCCCCCCCEEEE	64.38	21906983
186	Ubiquitination	DLRSGELKLIDFGSG ECCCCCEEEEECCCC	38.81	21906983
192	Phosphorylation	LKLIDFGSGALLKDT EEEEECCCCCEECCE	22.38	-
197	Ubiquitination	FGSGALLKDTVYTDF CCCCCEECCEEEECC	52.80	21963094
211	Phosphorylation	FDGTRVYSPPEWIRY CCCCEEECCHHHHCC	30.99	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIM3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PIM3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.