MCF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCF2_HUMAN
• UniProt AC: P10911
• Protein Name: Proto-oncogene DBL
• Gene Name: MCF2
• Organism: Homo sapiens (Human).
• Sequence Length: 925
• Subcellular Localization: Cytoplasm .; Isoform 1: Membrane.; Isoform 3: Membrane. Colocalizes with CDC42 to plasma membrane.
• Protein Description: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42..
• Protein Sequence: MAEANPRRGKMRFRRNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	PTSFLQRTFTDIGFW CCHHHHHHCCCCCCE	20.23	18452278
41	Phosphorylation	SFLQRTFTDIGFWFS HHHHHHCCCCCCEEC	26.54	18452278
48	Phosphorylation	TDIGFWFSQEDFMLK CCCCCEECCHHHHHH	24.21	19664994
72	Phosphorylation	SDLLTYIDDKQLTPE HHHHHHCCCCCCCCC	46.79	24719451
130	Phosphorylation	ELPDDIPSIEEILAI CCCCCCCCHHHHHHH	42.86	24275569
154	Ubiquitination	NDITAVTKEGKILLT CCEEEEECCCEEEEE	58.85	-
174	Phosphorylation	DTEGAVSSRLECHRQ CCCCCHHCHHHHHHH	34.00	23663014
393	Phosphorylation	YEFDVILSPELKVQM EEEEEEECHHHHHHH	12.76	24719451
401	Ubiquitination	PELKVQMKTIQLKLE HHHHHHHEEHHHHHH	25.94	-
406	Ubiquitination	QMKTIQLKLENIRSI HHEEHHHHHHHHHHH	37.06	-
412	Phosphorylation	LKLENIRSIFENQQA HHHHHHHHHHHCCCH	28.03	24719451
451	Phosphorylation	TSGTPFFSSKQGKKT CCCCCCCCCCCCCCC	36.68	24719451
452	Phosphorylation	SGTPFFSSKQGKKTW CCCCCCCCCCCCCCC	24.68	28060719
472	Phosphorylation	NLKIEVVPDCQEKRS CCEEEECCCCCHHCC	41.66	24719451
479	Phosphorylation	PDCQEKRSSGPSSSL CCCCHHCCCCCCCCC	51.19	25954137
510	Phosphorylation	LIQTERVYVRELYTV HHHHCCHHHHHHHHH	10.46	-
529	Phosphorylation	RAEMDNPEMFDLMPP CCCCCCHHHHHCCHH	59.75	24719451
588	Phosphorylation	RKDDFQMYAKYCQNK CCCHHHHHHHHHCCC	6.80	29759185
626	Phosphorylation	KHRLRLDSYLLKPVQ HHHHCCCHHHHHHHH	23.44	24719451
627	Phosphorylation	HRLRLDSYLLKPVQR HHHCCCHHHHHHHHH	18.73	24719451
636	Phosphorylation	LKPVQRITKYQLLLK HHHHHHHHHHHHHHH	26.36	26657352
638	Phosphorylation	PVQRITKYQLLLKEL HHHHHHHHHHHHHHH	8.85	26657352
655	Phosphorylation	YSKDCEGSALLKKAL HCCCCCCHHHHHHHH	8.08	-
693	Acetylation	GNLNELGKMIMQGGF CCHHHHHHHHHHCCC	37.57	20167786
708	Acetylation	SVWIGHKKGATKMKD EEEECCCCCCCCHHH	48.37	20167786
711	Phosphorylation	IGHKKGATKMKDLAR ECCCCCCCCHHHHHH	40.10	-
742	Phosphorylation	FCKRRVESGEGSDRY EEHHHCCCCCCCCCC	39.01	-
746	Phosphorylation	RVESGEGSDRYPSYS HCCCCCCCCCCCCCC	18.02	-
787	Phosphorylation	YGEKEEVYIVQASNV ECCCEEEEEEECCCC	9.92	-
792	Phosphorylation	EVYIVQASNVDVKMT EEEEEECCCCCCCHH	21.94	-
810 (in isoform 6)	Phosphorylation	-	46.63	23911959
849 (in isoform 2)	Phosphorylation	-	24.26	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:17178836

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCF2_HUMAN	MCF2	physical	11134331
GNA13_HUMAN	GNA13	physical	11062019
GBB1_HUMAN	GNB1	physical	10518015
HS90A_HUMAN	HSP90AA1	physical	17178836
CHIP_HUMAN	STUB1	physical	17178836
HSP7C_HUMAN	HSPA8	physical	17178836

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.