KCNA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA6_HUMAN
• UniProt AC: P17658
• Protein Name: Potassium voltage-gated channel subfamily A member 6
• Gene Name: KCNA6
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. [PubMed: 2347305]
• Protein Sequence: MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRSEKSLTLA -----CCCCCCEEEE	48.34	-
48	Phosphorylation	ERLVINISGLRFETQ CEEEEEECCCCEEEC	27.56	24719451
84	Phosphorylation	FDPLRNEYFFDRNRP ECCCCCCCCCCCCCC	17.07	-
92	Phosphorylation	FFDRNRPSFDAILYY CCCCCCCCCCEEEEE	32.30	-
98	Phosphorylation	PSFDAILYYYQSGGR CCCCEEEEEECCCCC	8.26	22817900
99	Phosphorylation	SFDAILYYYQSGGRL CCCEEEEEECCCCCC	7.50	22817900
100	Phosphorylation	FDAILYYYQSGGRLR CCEEEEEECCCCCCC	5.22	22817900
124	Phosphorylation	FLEEIRFYQLGDEAL HHHHHHHHHHCHHHH	7.93	26074081
212	Phosphorylation	GGNNGGVSRVSPVSR CCCCCCCCCCCCCCC	30.18	22985185
285	S-palmitoylation	LLVRFSACPSKPAFF HHHHHHCCCCCHHHH	3.66	-
356	Phosphorylation	VFRIFKLSRHSKGLQ HHHHHHHCCCCCHHH	28.65	26074081
359	Phosphorylation	IFKLSRHSKGLQILG HHHHCCCCCHHHHHH	27.58	26074081
368	Phosphorylation	GLQILGKTLQASMRE HHHHHHHHHHHHHHH	23.46	26074081
372	Phosphorylation	LGKTLQASMRELGLL HHHHHHHHHHHHHHH	12.86	26074081
440	Phosphorylation	VGGKIVGSLCAIAGV CCCCHHHHHHHHHHH	14.91	-
463	Phosphorylation	VIVSNFNYFYHRETE EEEECCCEEEECCCC	11.02	12151401
511	Phosphorylation	ANRERRPSYLPTPHR HCHHCCCCCCCCCCH	37.17	-
520	Phosphorylation	LPTPHRAYAEKRMLT CCCCCHHHHHHHCCC	18.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
511	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GET4_HUMAN	GET4	physical	26186194
KCAB2_HUMAN	KCNAB2	physical	26186194
ECHB_HUMAN	HADHB	physical	26186194
B3A2_HUMAN	SLC4A2	physical	26186194
ITIH3_HUMAN	ITIH3	physical	26186194
KCNA3_HUMAN	KCNA3	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
RHBL4_HUMAN	RHBDD1	physical	26186194
GOLM1_HUMAN	GOLM1	physical	26186194
DOLK_HUMAN	DOLK	physical	26186194
KCNA3_HUMAN	KCNA3	physical	28514442
DOLK_HUMAN	DOLK	physical	28514442
KCAB2_HUMAN	KCNAB2	physical	28514442
GOLM1_HUMAN	GOLM1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.