KCNA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA3_HUMAN
• UniProt AC: P22001
• Protein Name: Potassium voltage-gated channel subfamily A member 3
• Gene Name: KCNA3
• Organism: Homo sapiens (Human).
• Sequence Length: 575
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient..
• Protein Sequence: MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDERLSLLRSPPP --CCHHHHHHCCCCC	31.42	27080861
10	Phosphorylation	ERLSLLRSPPPPSAR HHHHHHCCCCCCCHH	41.55	28270605
15	Phosphorylation	LRSPPPPSARHRAHP HCCCCCCCHHCCCCC	43.65	27080861
40	Phosphorylation	HTLVNHGYAEPAAGR CCCEECCCCCCCCCC	10.55	27642862
111	Phosphorylation	ERVVINISGLRFETQ CEEEEEECCCCCHHH	27.56	24719451
120	Ubiquitination	LRFETQLKTLCQFPE CCCHHHHHHHHCCHH	29.63	29967540
134	Ubiquitination	ETLLGDPKRRMRYFD HHHHCCHHHHHHCCC	58.33	-
135	Phosphorylation	TLLGDPKRRMRYFDP HHHCCHHHHHHCCCC	42.91	11812778
147	Phosphorylation	FDPLRNEYFFDRNRP CCCCCCCCCCCCCCC	17.07	-
155	Phosphorylation	FFDRNRPSFDAILYY CCCCCCCCCCEEEEE	32.30	-
161	Phosphorylation	PSFDAILYYYQSGGR CCCCEEEEEECCCCC	8.26	19166614
162	Phosphorylation	SFDAILYYYQSGGRI CCCEEEEEECCCCCE	7.50	19166614
163	Phosphorylation	FDAILYYYQSGGRIR CCEEEEEECCCCCEE	5.22	19166614
187	Phosphorylation	FSEEIRFYQLGEEAM CCCCHHHHHHHHHHH	7.93	22817900
196	Ubiquitination	LGEEAMEKFREDEGF HHHHHHHHHHHCCCC	36.31	-
279	N-linked_Glycosylation	DSFEAAGNSTSGSRA HHHHHCCCCCCCCCC	37.07	UniProtKB CARBOHYD
317	S-palmitoylation	LLVRFFACPSKATFS HHHHHHHCCCCCHHC	3.10	-
378	Phosphorylation	VFRIFKLSRHSKGLQ HHHHHHHCCCCCHHH	28.65	26074081
447	Phosphorylation	VTMTTVGYGDMHPVT EEEECCCCCCCEEEE	12.96	11812778
485	Phosphorylation	VIVSNFNYFYHRETE EEEECCCEEEECCCC	11.02	12151401
487	Phosphorylation	VSNFNYFYHRETEGE EECCCEEEECCCCCC	6.93	12151401
491	Phosphorylation	NYFYHRETEGEEQSQ CEEEECCCCCCCCCC	49.61	28270605
497	Phosphorylation	ETEGEEQSQYMHVGS CCCCCCCCCEEEHHH	26.93	28270605
499	Phosphorylation	EGEEQSQYMHVGSCQ CCCCCCCEEEHHHHH	8.40	19166614
504	Phosphorylation	SQYMHVGSCQHLSSS CCEEEHHHHHHHCCC	14.98	28270605
509	Phosphorylation	VGSCQHLSSSAEELR HHHHHHHCCCHHHHH	21.81	28270605
510	Phosphorylation	GSCQHLSSSAEELRK HHHHHHCCCHHHHHH	39.67	28270605
511	Phosphorylation	SCQHLSSSAEELRKA HHHHHCCCHHHHHHH	36.00	28270605
520	Phosphorylation	EELRKARSNSTLSKS HHHHHHHCCCCCCHH	39.74	-
522	Phosphorylation	LRKARSNSTLSKSEY HHHHHCCCCCCHHHE	31.78	26657352
523	Phosphorylation	RKARSNSTLSKSEYM HHHHCCCCCCHHHEE	39.02	-
525	Phosphorylation	ARSNSTLSKSEYMVI HHCCCCCCHHHEEEE	33.94	-
526	Ubiquitination	RSNSTLSKSEYMVIE HCCCCCCHHHEEEEE	50.88	-
527	Phosphorylation	SNSTLSKSEYMVIEE CCCCCCHHHEEEEEC	30.50	28796482
529	Phosphorylation	STLSKSEYMVIEEGG CCCCHHHEEEEECCC	12.08	28796482
564	Phosphorylation	TTNNNPNSCVNIKKI ECCCCCCCCEEEEEE	22.24	-
569	Ubiquitination	PNSCVNIKKIFTDV- CCCCEEEEEEEECC-	34.31	22505724
570	Ubiquitination	NSCVNIKKIFTDV-- CCCEEEEEEEECC--	38.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
135	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
161	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
162	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
163	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
187	Y	Phosphorylation	Kinase	SRC	P12931	PSP
447	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
499	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
499	Y	Phosphorylation	Kinase	SRC	P12931	PSP
520	S	Phosphorylation	Kinase	PKA	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNA4_HUMAN	KCNA4	physical	10428084
KCNA1_HUMAN	KCNA1	physical	10428084
KCNA2_HUMAN	KCNA2	physical	10428084
DLG4_HUMAN	DLG4	physical	17854350
CD3D_HUMAN	CD3D	physical	12604782
BAX_HUMAN	BAX	physical	20114030
KCNA5_HUMAN	KCNA5	physical	18218624
CAV1_HUMAN	CAV1	physical	18218624
TFR1_HUMAN	TFRC	physical	18218624
DLG4_HUMAN	DLG4	physical	21726550
UBF1_HUMAN	UBTF	physical	25829491
DFB4A_HUMAN	DEFB4A	physical	25944908
NED4L_HUMAN	NEDD4L	physical	27146988

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00619: Verapamil hydrochloride (JP16/USP); Calan (TN); Covera-hs (TN); Vasolan (TN); Verelan (TN)
• D02356: Verapamil (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.