DYRK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYRK4_HUMAN
• UniProt AC: Q9NR20
• Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 4
• Gene Name: DYRK4
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Isoform 1: Cytoplasm .; Isoform 4: Cytoplasm . Nucleus .
• Protein Description: Possible non-essential role in spermiogenesis..
• Protein Sequence: MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPASELKASEI ----CCHHHHCHHCC	37.28	25404012
9	Phosphorylation	PASELKASEIPFHPS CHHHHCHHCCCCCCC	34.18	25404012
16	Phosphorylation	SEIPFHPSIKTQDPK HCCCCCCCCCCCCCC	28.31	25404012
37	Phosphorylation	KKQKVTLTAAEALKL CCCCCCCHHHHHHHH	17.92	-
71	Ubiquitination	WFLGLEAKKLDTAPE HHHHHHHCCCCCCCH	44.48	-
72	Ubiquitination	FLGLEAKKLDTAPEK HHHHHHCCCCCCCHH	59.65	-
205	Phosphorylation	NFQGFSLSIVRRFTL CCCCCCHHHHHHHHH	20.17	24719451
211	Phosphorylation	LSIVRRFTLSVLKCL HHHHHHHHHHHHHHH	19.13	30619164
213	Phosphorylation	IVRRFTLSVLKCLQM HHHHHHHHHHHHHHH	23.50	30619164
222	Phosphorylation	LKCLQMLSVEKIIHC HHHHHHHCCCEEECC	23.92	-
262	Phosphorylation	CYEHQKVYTYIQSRF HHHHHHHHHHHHHHH	10.81	24260401
263	Phosphorylation	YEHQKVYTYIQSRFY HHHHHHHHHHHHHHC	19.69	27794612
264	Phosphorylation	EHQKVYTYIQSRFYR HHHHHHHHHHHHHCC	4.54	19664994
267	Phosphorylation	KVYTYIQSRFYRSPE HHHHHHHHHHCCCCH	18.13	22617229
356	Phosphorylation	NNRGKKRYPDSKDLT CCCCCCCCCCCCCCE	21.92	22817900
360	Sumoylation	KKRYPDSKDLTMVLK CCCCCCCCCCEEHHH	65.23	-
417	Ubiquitination	PRPQTLRKSNSFFPS CCCCCHHCCCCCCCC	58.04	-
418	Phosphorylation	RPQTLRKSNSFFPSE CCCCHHCCCCCCCCC	31.13	24505115
426	Phosphorylation	NSFFPSETRKDKVQG CCCCCCCHHHHCCCC	47.56	24505115
437	Phosphorylation	KVQGCHHSSRKADEI CCCCCCCCHHHHHHH	14.26	-
445	Phosphorylation	SRKADEITKETTEKT HHHHHHHHHHHHHCC	22.30	-
457	Phosphorylation	EKTKDSPTKHVQHSG HCCCCCCCCCCCCCC	37.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
264	Y	Phosphorylation	Kinase	DYRK4	Q9NR20	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYRK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYRK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR33_HUMAN	WDR33	physical	23602568
TECR_HUMAN	TECR	physical	23602568
YMEL1_HUMAN	YME1L1	physical	23602568
RCN1_HUMAN	RCN1	physical	23602568
RBBP4_HUMAN	RBBP4	physical	23602568
HAX1_HUMAN	HAX1	physical	23602568
AT1A1_HUMAN	ATP1A1	physical	23602568
UBP11_HUMAN	USP11	physical	23602568
CALL5_HUMAN	CALML5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-264, AND MASSSPECTROMETRY.
PubMed: 19534553

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-264, AND MASSSPECTROMETRY.
PubMed: 18083107