KLH29_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH29_HUMAN
• UniProt AC: Q96CT2
• Protein Name: Kelch-like protein 29
• Gene Name: KLHL29
• Organism: Homo sapiens (Human).
• Sequence Length: 875
• Protein Sequence: MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPINQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQAPVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	GGTASSLSVRPGLLP CCCCCCCEECCCCCC	39.42	24719451
78	Phosphorylation	APCTTGSSEAITSLV CCCCCCCHHHHHHHH	20.37	22210691
83	Phosphorylation	GSSEAITSLVASSAS CCHHHHHHHHHHCCC	38.92	22210691
93	Phosphorylation	ASSASAVTTKAPGIS HHCCCCCCCCCCCCC	35.96	-
100	Phosphorylation	TTKAPGISKGDSQSQ CCCCCCCCCCCCCCC	36.71	22210691
100	O-linked_Glycosylation	TTKAPGISKGDSQSQ CCCCCCCCCCCCCCC	36.71	31492838
106	Phosphorylation	ISKGDSQSQGLATSI CCCCCCCCCCCCCCE	42.07	-
111	Phosphorylation	SQSQGLATSIRWGQT CCCCCCCCCEECCCC	3.56	-
349	Phosphorylation	VHQNVLASCSLYFKD EEHHHHHHCHHHHHH	3.99	18452278
432	Phosphorylation	SFLEKQLTASNCLGV HHHHHHCHHHHHHHH	37.25	22210691
452	Phosphorylation	AMQCSELYHMAKAFA HHHHHHHHHHHHHHH	22.08	22210691
474	Phosphorylation	AAQEEILSISKDDFI HHHHHHHHCCCCCEE	11.31	24719451
476	Phosphorylation	QEEILSISKDDFIAY HHHHHHCCCCCEEEE	26.72	22210691
498	Phosphorylation	TKAEELVYETVIKWI CCHHHHHHHHHHHHH	71.38	24719451
500	Phosphorylation	AEELVYETVIKWIKK HHHHHHHHHHHHHHC	4.59	24719451
571	Phosphorylation	HARQEMQTPRTRPRL HHHHHCCCCCCCCCC	14.26	30206219
574	Phosphorylation	QEMQTPRTRPRLSAG HHCCCCCCCCCCCCC	24.29	30206219
598	Phosphorylation	GRQMVGMTQRSLVAV CHHEECCCCCEEEEE	3.94	25332170
824	Phosphorylation	VVLDGKIYATGGIVS EEECCEEEEECCEEC		-
826	Phosphorylation	LDGKIYATGGIVSSE ECCEEEEECCEECCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH29_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH29_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH29_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DJB12_HUMAN	DNAJB12	physical	24778252
DHE3_HUMAN	GLUD1	physical	24778252
KBTB6_HUMAN	KBTBD6	physical	24778252
KLH21_HUMAN	KLHL21	physical	24778252
KLHL9_HUMAN	KLHL9	physical	24778252
QPCTL_HUMAN	QPCTL	physical	24778252
SFXN2_HUMAN	SFXN2	physical	24778252
SSRG_HUMAN	SSR3	physical	24778252
CHIP_HUMAN	STUB1	physical	24778252
ZBT21_HUMAN	ZBTB21	physical	24778252
AGO2_HUMAN	AGO2	physical	24778252
KBTB8_HUMAN	KBTBD8	physical	28514442
ZBT10_HUMAN	ZBTB10	physical	28514442
NPHP3_HUMAN	NPHP3	physical	28514442
KLH21_HUMAN	KLHL21	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.