TNI3K_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNI3K_HUMAN
• UniProt AC: Q59H18
• Protein Name: Serine/threonine-protein kinase TNNI3K
• Gene Name: TNNI3K {ECO:0000312|EMBL:AAH32865.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 835
• Subcellular Localization: Nucleus . Cytoplasm . Expressed at lower levels in the cytoplasm.
• Protein Description: May play a role in cardiac physiology..
• Protein Sequence: MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Ubiquitination	DDLQIKEKELTELRN HHHCCCHHHHHHHHH	53.69	-
62	Phosphorylation	FSKVNLNYRTENGLS HHHCCCCCCCCCCEE	23.29	-
95	Phosphorylation	MLKGLRPSRLTRNGF HHCCCCHHHCCCCCC	33.22	24719451
293	Phosphorylation	AKEIIQISGTESLTK HHHHHHHCCCCCCCC	24.24	29083192
295	Phosphorylation	EIIQISGTESLTKEN HHHHHCCCCCCCCCC	18.66	29083192
297	Phosphorylation	IQISGTESLTKENIF HHHCCCCCCCCCCCC	40.97	29083192
299	Phosphorylation	ISGTESLTKENIFSE HCCCCCCCCCCCCCH	45.66	29083192
305	Phosphorylation	LTKENIFSETAFHSA CCCCCCCCHHHHHHH	30.18	29978859
307	Phosphorylation	KENIFSETAFHSACT CCCCCCHHHHHHHHH	33.16	29978859
311	Phosphorylation	FSETAFHSACTYGKS CCHHHHHHHHHHCCH	20.70	29978859
314	Phosphorylation	TAFHSACTYGKSIDL HHHHHHHHHCCHHHH	34.72	29978859
315	Phosphorylation	AFHSACTYGKSIDLV HHHHHHHHCCHHHHH	23.57	29978859
318	Phosphorylation	SACTYGKSIDLVKFL HHHHHCCHHHHHHHH	19.57	23403867
416	Phosphorylation	DELPCNEYSQPGGDG CCCCCCCCCCCCCCC	9.90	-
424	Phosphorylation	SQPGGDGSYVSVPSP CCCCCCCCEEECCCC	27.40	-
425	Phosphorylation	QPGGDGSYVSVPSPL CCCCCCCEEECCCCC	11.41	-
427	Phosphorylation	GGDGSYVSVPSPLGK CCCCCEEECCCCCHH	21.78	-
471	Phosphorylation	EFHEIIGSGSFGKVY EEEEEECCCCCCCEE	22.36	26699800
473	Phosphorylation	HEIIGSGSFGKVYKG EEEECCCCCCCEECC	32.30	26699800
581	Phosphorylation	MEYLHNLTQPIIHRD HHHHHHCCCCEECCC	37.30	-
622	Phosphorylation	SLDEDNMTKQPGNLR HCCCCCCCCCCCCCC	32.55	29083192
771	Phosphorylation	RSRFELEYALNARSY HHHHHHHHHHHHCHH	29.07	-
788	Phosphorylation	LSQSAGQYSSQGLSL HHHCCCCCCCCCCCH	14.90	-
804	Phosphorylation	EMKRSLQYTPIDKYG HHHHHCCCCCCCCCC	21.56	-
805	Phosphorylation	MKRSLQYTPIDKYGY HHHHCCCCCCCCCCC	10.78	-
810	Phosphorylation	QYTPIDKYGYVSDPM CCCCCCCCCCCCCCC	15.22	-
812	Phosphorylation	TPIDKYGYVSDPMSS CCCCCCCCCCCCCCC	8.16	-
814	Phosphorylation	IDKYGYVSDPMSSMH CCCCCCCCCCCCCCC	27.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNI3K_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNI3K_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNI3K_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNI3_HUMAN	TNNI3	physical	12721663
MYPC3_HUMAN	MYBPC3	physical	12721663
ACTC_HUMAN	ACTC1	physical	12721663
ACTS_HUMAN	ACTA1	physical	12721663
FABPH_HUMAN	FABP3	physical	12721663
ECHB_HUMAN	HADHB	physical	12721663
AIP_HUMAN	AIP	physical	12721663

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.