TIE1_HUMAN - dbPTM
TIE1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TIE1_HUMAN
UniProt AC P35590
Protein Name Tyrosine-protein kinase receptor Tie-1
Gene Name TIE1
Organism Homo sapiens (Human).
Sequence Length 1138
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis..
Protein Sequence MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83N-linked_GlycosylationPPLRLARNGSHQVTL
CCCEEECCCCCEEEE		51.19UniProtKB CARBOHYD
161N-linked_GlycosylationTDVIWKSNGSYFYTL
CCEEEEECCCEEEEE		39.44UniProtKB CARBOHYD
384PhosphorylationNPFPVRGSIELRKPD
CCCCCCCEEEEECCC		11.4330576142
393PhosphorylationELRKPDGTVLLSTKA
EEECCCCEEEEEEEE		18.5030576142
397PhosphorylationPDGTVLLSTKAIVEP
CCCEEEEEEEEEECC		24.5724719451
397O-linked_GlycosylationPDGTVLLSTKAIVEP
CCCEEEEEEEEEECC		24.5730620550
407PhosphorylationAIVEPEKTTAEFEVP
EEECCCCCCCCEECC		29.5829759185
408PhosphorylationIVEPEKTTAEFEVPR
EECCCCCCCCEECCE		34.9529759185
472PhosphorylationVSPLVSFSGDGPIST
EECCEECCCCCCEEE		28.59-
478PhosphorylationFSGDGPISTVRLHYR
CCCCCCEEEEEEEEC		24.80-
503N-linked_GlycosylationIVVDPSENVTLMNLR
EEECCCCCEEEEECC		36.09UniProtKB CARBOHYD
513PhosphorylationLMNLRPKTGYSVRVQ
EEECCCCCCEEEEEE		43.9920068231
515PhosphorylationNLRPKTGYSVRVQLS
ECCCCCCEEEEEEEC		14.8220068231
516PhosphorylationLRPKTGYSVRVQLSR
CCCCCCEEEEEEECC		12.5620068231
522PhosphorylationYSVRVQLSRPGEGGE
EEEEEEECCCCCCCC		21.2420068231
539PhosphorylationWGPPTLMTTDCPEPL
CCCCEEEECCCCCCC		23.69-
540PhosphorylationGPPTLMTTDCPEPLL
CCCEEEECCCCCCCC		22.95-
596N-linked_GlycosylationRGQERRENVSSPQAR
CCHHHHHCCCCHHHH		36.84UniProtKB CARBOHYD
598PhosphorylationQERRENVSSPQARTA
HHHHHCCCCHHHHHH		48.13-
599PhosphorylationERRENVSSPQARTAL
HHHHCCCCHHHHHHH		19.42-
604PhosphorylationVSSPQARTALLTGLT
CCCHHHHHHHHHCCC		25.36-
608PhosphorylationQARTALLTGLTPGTH
HHHHHHHHCCCCCCC		30.87-
663PhosphorylationSDSEIQLTWKHPEAL
CCCCEEEEECCCCCC		18.98-
709N-linked_GlycosylationSTIIRGLNASTRYLF
HHHHHCCCHHHHHHH		34.37UniProtKB CARBOHYD
912PhosphorylationGACKNRGYLYIAIEY
HHHCCCCEEEEEEEE		7.9720068231
914PhosphorylationCKNRGYLYIAIEYAP
HCCCCEEEEEEEECC		4.6520068231
922PhosphorylationIAIEYAPYGNLLDFL
EEEEECCCCCHHHHH		15.5222210691
1007PhosphorylationLSRGEEVYVKKTMGR
CCCCCEEEEEECCCC		15.16-
1011PhosphorylationEEVYVKKTMGRLPVR
CEEEEEECCCCCCCE		21.09-
1027PhosphorylationMAIESLNYSVYTTKS
EEEEECCEEEEECHH		12.5717360941
1030PhosphorylationESLNYSVYTTKSDVW
EECCEEEEECHHHHH		11.62-
1031PhosphorylationSLNYSVYTTKSDVWS
ECCEEEEECHHHHHH		26.1222210691
1032PhosphorylationLNYSVYTTKSDVWSF
CCEEEEECHHHHHHH		15.74-
1063PhosphorylationGMTCAELYEKLPQGY
CCCHHHHHHHCCCCC		11.5211080633
1083PhosphorylationRNCDDEVYELMRQCW
CCCCHHHHHHHHHHH		10.9923186163
1117PhosphorylationMLEARKAYVNMSLFE
HHHHHHHHHCHHHHH		8.7322210691
1121PhosphorylationRKAYVNMSLFENFTY
HHHHHCHHHHHCCCE		25.3822210691
1128PhosphorylationSLFENFTYAGIDATA
HHHHCCCEECCCCCC		9.9329759185
1134PhosphorylationTYAGIDATAEEA---
CEECCCCCCCCC---		30.7422210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TIE1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TIE1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TIE1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANGP4_HUMANANGPT4physical
10051567
TIE2_HUMANTEKphysical
10995770
MDFI_HUMANMDFIphysical
19060904
RBPMS_HUMANRBPMSphysical
25416956
K1C40_HUMANKRT40physical
25416956
MTMRE_HUMANMTMR14physical
28065597
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TIE1_HUMAN

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Related Literatures of Post-Translational Modification

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